Metabolic Syndrome and Rheumatoid Arthritis Activity: An Analysis of Clinical, Laboratory, and Ultrasound Parameters

Grzechnik, Krzysztof; Targońska-Stępniak, Bożena

doi:10.3390/nu15224756

Cited by 5 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitamin D has a protective role against periodontal diseases through bone preservation and anti-inflammatory and antibacterial activity [31]. Other effects that vitamin D has on bones can help improve TMJ joint pain and bone repair caused by osteonecrosis, but more research is needed [45,46].…”

Section: Discussionmentioning

confidence: 99%

Investigating the Impact of Vitamin D Deficiency on the Mouth, Jaw And Face: A Review Study

Botelho,

Machado-,

Proença

et al. 2024

Ann Dent Spec

View full text Add to dashboard Cite

Vitamin D is one of the steroid hormones that is mainly obtained from food and diet supplements and exposure to sunlight. This vitamin plays a vital role in bone turnover and calcium phosphate homeostasis and as a result the musculoskeletal system. In addition, vitamin D is important in the immune system. This research aimed to review the manifestations of vitamin D deficiency in the mouth, jaw, and face. In this review study, articles published in the English language between 2010 and 2024 were searched in Scopus, Google Scholar, Medline, and PubMed databases. By examining and studying several articles about vitamin D's role in various structures of the body including the mouth and teeth, the impacts of its deficiency in the occurrence of the disease, and the utilization of its supplements in disease recovery, it concludes that this vitamin plays a prominent role in the mouth and teeth health and it has an immune system. Although there were conflicting findings about the impact of vitamin D on external root resorption in Sjogren's syndrome and orthodontics. Therefore, clinical trial research is necessary to confirm the hypotheses.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigating the Impact of Vitamin D Deficiency on the Mouth, Jaw And Face: A Review Study

Botelho,

Machado-,

Proença

et al. 2024

Ann Dent Spec

View full text Add to dashboard Cite

show abstract

“…Many autoimmune disorders such as systemic lupus erythematosus, polymyositis, dermatomyositis, and rheumatoid arthritis have been connected with chronic urticaria (23). In this regard, H. pylori infection and/or MetS are linked to such disorders as systemic lupus erythematosus and rheumatoid arthritis (24)(25)(26)(27). MCs also contribute to the pathophysiology of these autoimmune disorders (26,28).…”

Section: Introductionmentioning

confidence: 99%

Impact of Helicobacter pylori and metabolic syndrome-related mast cell activation on cardiovascular diseases

Doulberis,

Papaefthymiou,

Polyzos

et al. 2024

Front. Gastroenterol.

View full text Add to dashboard Cite

Helicobacter pylori, a widely renowned bacterium, has recently gained attention owing to its potential impact on extragastric health. The emergence of research linking H. pylori infection with metabolic syndrome (MetS)-related cardiovascular diseases (CVDs) has raised intriguing questions about the pathogenic linkage and its translational implications for clinicians. MetS encompasses a collection of metabolic abnormalities that considerably elevate the risk of CVDs and cerebrovascular diseases. Emerging evidence supports a potential pathogenetic role of H. pylori for MetS-related disorders through mechanisms implicating chronic smoldering inflammation, insulin resistance (IR), and modulation of immune responses. One intriguing aspect of this possible connection is the role of mast cells (MCs), a subset of immune cells representing innate immune system effector cells. They play a fundamental role in innate immune responses and the modulation of adaptive immunity. Activated MCs are commonly found in patients with MetS-related CVD. Recent studies have also suggested that H. pylori infection may activate MCs, triggering the release of pro-inflammatory mediators that contribute to IR and atherosclerosis. Understanding these intricate interactions at the cellular level provides new insights into the development of therapeutic strategies targeting both H. pylori infection and MetS-related MCs activation. This review investigates the current state of research regarding the potential impact of H. pylori infection and MetS-related MCs activation on the pathophysiology of CVD, thereby opening up new avenues for related research and paving the way for innovative approaches to prevention and treatment in clinical practice

show abstract

Metabolic Syndrome, Adipokines, and Response to Advanced Therapies in Rheumatoid Arthritis

Baker,

Reed,

Mikuls

et al. 2024

Arthritis & Rheumatology

View full text Add to dashboard Cite

PurposeWe determined if metabolic syndrome, its components, and adipokines (adiponectin, leptin, Fibroblast Growth Factor‐21) were associated with response to advanced therapies among patients with rheumatoid arthritis (RA).MethodsThis study included participants with RA initiating either TNFi or non‐TNFi biologic therapies from the Comparative Effectiveness Registry to study Therapies for Arthritis and Inflammatory Conditions (CERTAIN) cohort within the CorEvitas registry. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III definition. Adipokines were assessed on stored samples from a sub‐sample of responders and non‐responders (N=200). The primary outcome was the achievement of a change as large as the minimal clinically important difference (MCID) for the Clinical Disease Activity Index (CDAI) at 6 months.ResultsAmong 2,368 participants, 687 (29%) had metabolic syndrome. Metabolic syndrome was associated with lower odds of achieving CDAI MCID [OR (95% CI): 0.69 (0.56,0.86) p=0.001] with a dose‐dependent decrease in response rate according to the number of components present. Model fit was superior for metabolic syndrome compared to BMI. Associations between metabolic syndrome and MCID achievement were similar between patients receiving TNFi [OR (95% CI): 0.65 (0.49,0.87) p=0.003] v. non‐TNF therapies [OR (95% CI): 0.76 (0.55,1.04) p=0.08)] (p‐for‐interaction=0.49). Adipokines were not associated with MCID achievement.ConclusionsMetabolic syndrome is associated with lower response rates with the initiation of an advanced therapy in RA, with similar effects for both TNFi and non‐TNFi agents. Adipokines were strongly associated with metabolic syndrome but were not associated with clinical response.

show abstract

Metabolic Syndrome and Rheumatoid Arthritis Activity: An Analysis of Clinical, Laboratory, and Ultrasound Parameters

Cited by 5 publications

References 38 publications

Investigating the Impact of Vitamin D Deficiency on the Mouth, Jaw And Face: A Review Study

Investigating the Impact of Vitamin D Deficiency on the Mouth, Jaw And Face: A Review Study

Impact of Helicobacter pylori and metabolic syndrome-related mast cell activation on cardiovascular diseases

Metabolic Syndrome, Adipokines, and Response to Advanced Therapies in Rheumatoid Arthritis

Contact Info

Product

Resources

About