Metabolic syndrome and risk of stroke

Roever, Leonardo; Resende, Elmiro Santos; Diniz, Angélica Lemos Debs; Penha-Silva, Nilson; O’Connell, João Lucas; Gomes, Paulo Fernando Silva; Zanetti, Hugo Ribeiro; Roerver-Borges, Anaisa Silva; Veloso, Fernando César; Fidale, Thiago Montes; Casella-Filho, Antonio; Dourado, Paulo Magno Martins; Chagas, Antônio Carlos Palandri; Ali-Hasan-Al-Saegh, Sadeq; Reis, Paulo Eduardo Ocke; Pinto, Rogério de Melo Costa; Oliveira, Gustavo B.F.; Avezum, Álvaro; Neto, Mansueto Gomes; Durães, André Rodrigues; Silva, Rose Mary Ferreira Lisboa da; Grande, Antônio José; Denardi, Celise; Lópes, Renato D.; Nerlekar, Nitesh; Alizadeh, Shahab; Hernandez, Adrián V.; Biondi‐Zoccai, Giuseppe

doi:10.1097/md.0000000000009862

Cited by 11 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high-caloric diet has been broadly characterized as the trigger of T2DM 28 – 30 , and T2DM accounts for 90%–95% of all DM cases, IR being the typical symptom and mechanism at the early stage of dietary-induced T2DM 4 – 6 , 31 . High-fat-induced IR could generally associate with alterations in lipid cellular intake and accumulation, followed by disorders of the metabolism of β-cells, stroke, and other diseases 32 , 33 . Here in our model, the high fat diet for 4 wk successfully induced hyperinsulinemia and elevation of blood glucose concentration, which was associated with lipometabolic disorders and rising ALT/AST.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bone Marrow-Derived Mesenchymal Stem Cells Restored High-Fat-Fed Induced Hyperinsulinemia in Rats at Early Stage of Type 2 Diabetes Mellitus

Han

Qian

et al. 2020

Cell Transplant

View full text Add to dashboard Cite

Numerous studies have proposed the transplantation of mesenchymal stem cells (MSCs) in the treatment of typical type 2 diabetes mellitus (T2DM). We aimed to find a new strategy with MSC therapy at an early stage of T2DM to efficiently prevent the progressive deterioration of organic dysfunction. Using the high-fat-fed hyperinsulinemia rat model, we found that before the onset of typical T2DM, bone marrow-derived MSCs (BM-MSCs) significantly attenuated rising insulin with decline in glucose as well as restored lipometabolic disorder and liver dysfunction. BM-MSCs also favored the histological structure recovery and proliferative capacity of pancreatic islet cells. More importantly, BM-MSC administration successfully reversed the abnormal expression of insulin resistance-related proteins including GLUT4, phosphorylated insulin receptor substrate 1, and protein kinase Akt and proinflammatory cytokines IL-6 and TNFα in liver. These findings suggested that MSCs transplantation during hyperinsulinemia could prevent most potential risks of T2DM for patients.

show abstract

Section: Discussionmentioning

confidence: 99%

“…IR could produce hyperinsulinemia, this in turn induces multiple organic dysfunction due to an abnormal intake of lipid and lipid accumulation in cells 28 , 32 . We found that MSCs restored lipometabolic disorders and liver dysfunction, as evidenced by the concentration of LDL/TG/TC and AST/ALT.…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow-Derived Mesenchymal Stem Cells Restored High-Fat-Fed Induced Hyperinsulinemia in Rats at Early Stage of Type 2 Diabetes Mellitus

Han

Qian

et al. 2020

Cell Transplant

View full text Add to dashboard Cite

show abstract

“…A cluster of metabolic and cardiovascular risk factors known as metabolic syndrome includes central obesity, dyslipidemia, hypertension, hyperinsulinemia, and insulin resistance (IR) [ 1 , 2 ]. Mellitus type II, cardiovascular diseases (CVD), malignancies, and overall mortality are all strongly correlated with MS [ 3 , 4 , 5 , 6 , 7 ]. Additionally, there is a strong link between MS and psychological strain [ 8 ], as well as mental disorders, including depression, schizophrenia, and bipolar disorder [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Predictive Value of Lipid Accumulation Product for Identifying Metabolic Syndrome in the General Population of China

Shao,

Li,

et al. 2023

Nutrients

View full text Add to dashboard Cite

The purpose of this research was to evaluate the lipid accumulation product (LAP)’s accuracy and predictive value for identifying metabolic syndrome (MS) in the general Chinese population compared with other obesity indicators. Baseline survey information from a population-based cohort study carried out in Shanghai’s Songjiang District was used in this research. Odds ratios (OR) and a 95% confidence interval (CI) were obtained by logistic regression. The ability of each variable to detect MS was assessed using the receiver operating characteristic curve (ROC). The optimum cut-off point for each indicator was selected using Youden’s index. The survey involved 35,446 participants in total. In both genders, the prevalence of MS rose as the LAP increased (p < 0.001). The LAP’s AUC was 0.901 (95%CI: 0.895–0.906) in males and 0.898 (95%CI: 0.893–0.902) in females, making it substantially more predictive of MS than other variables (BMI, WC, WHR, WHtR). The optimal cutoff point of the LAP for men and women was 36.04 (Se: 81.91%, Sp: 81.06%) and 34.95 (Se: 80.93%, Sp: 83.04%). The Youden index of the LAP was 0.64 for both sexes. Our findings imply that the LAP, compared to other obesity markers in China, is a more accurate predictor of MS.

show abstract

“…Many studies have demonstrated that Metabolic Syndrome (MetS), defined as a cluster of interconnected metabolic risk factors (including abdominal obesity, elevated fasting glucose, hypertriglyceridemia, hypertension, and low High-Density Lipoprotein (HDL) cholesterol levels), increases the risk for atherosclerosis and cardiovascular disease [1][2][3][4][5][6]. In addition, the recent interest of the scientific community has focused on the possible involvement of insulin resistance as a linking factor [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The Risk of Carotid Plaque Instability in Patients with Metabolic Syndrome: It is Higher in Women with Hypertriglyceridemia

Servadei

Anemona

Cardellini

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Metabolic syndrome certainly favors growth of carotid plaque; however, it is uncertain if it determines plaque destabilization. Furthermore, it is likely that only some components of metabolic syndrome are associated with increased risk of plaque destabilization. Therefore, we evaluated the effect of different elements of metabolic syndrome, individually and in association, on carotid plaques destabilization. Methods: A total of 186 carotid endarterectomies from symptomatic and asymptomatic patients were histologically analysed and correlated with major cardiovascular risk factors. Results: Metabolic syndrome, regardless of the cluster of its components, is not associated with a significant increase in risk of plaque destabilization, rather with the presence of stable plaques. The incidence of unstable plaques in patients with metabolic syndrome is quite low (43.9%), when compared with that seen in the presence of some risk factors, but significantly increases in the subgroup of female patients with hypertriglyceridemia, showing an odds ratio of 3.01 (CI 95% 0.25 - 36.30). Conclusions: Our data may help to identify patients with real increased risk of acute cerebrovascular diseases and may support the hypothesis that the control of hypertriglyceridemia should be a key point on prevention of carotid atherosclerotic plaque destabilization, especially in post-menopausal female patients. Keywords: Metabolic syndrome, carotid, histology, hypertriglyceridemia , post-menopause.

show abstract

Metabolic syndrome and risk of stroke

Abstract: Supplemental Digital Content is available in the text

Cited by 11 publications

References 16 publications

Bone Marrow-Derived Mesenchymal Stem Cells Restored High-Fat-Fed Induced Hyperinsulinemia in Rats at Early Stage of Type 2 Diabetes Mellitus

Bone Marrow-Derived Mesenchymal Stem Cells Restored High-Fat-Fed Induced Hyperinsulinemia in Rats at Early Stage of Type 2 Diabetes Mellitus

Enhanced Predictive Value of Lipid Accumulation Product for Identifying Metabolic Syndrome in the General Population of China

The Risk of Carotid Plaque Instability in Patients with Metabolic Syndrome: It is Higher in Women with Hypertriglyceridemia

Contact Info

Product

Resources

About