Metabolic syndrome and risk of major coronary events among the urban diabetic patients: North Indian Diabetes and Cardiovascular Disease Study—NIDCVD-2

Bhatti, Gurjit Kaur; Bhadada, Sanjay Kumar; Vijayvergiya, Rajesh; Mastana, Sarabjit S.; Bhatti, Jasvinder Singh

doi:10.1016/j.jdiacomp.2015.07.008

Cited by 43 publications

(52 citation statements)

References 35 publications

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“…The increase in arterial stiffness linked with age may be attributed to change in estrogen levels after attaining menopausal state. In concordance with other studies, present study also showed increased incidence of MS with advancing age, which can be attributed to increased hypertension, obesity and dyslipidemia with age [11,39,41,42].…”

Section: Discussionsupporting

confidence: 93%

“…A recent study has indicated high prevalence of MS and positive association with its different components with high risk of CVD in North Indian diabetic patients [11]. In another report, MS was found to increase the relative CVD risk in males and for T2DM in both genders of middle age [42].…”

Section: Discussionmentioning

confidence: 99%

“…Its value as a distinct diagnostic entity is still a matter of debate. Limited studies on MS prevalence were reported from India until now [9][10][11]. Various criteria for diagnosis for MS have been developed in past years.…”

Section: Background and Aimsmentioning

confidence: 99%

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Assessment of Metabolic Syndrome and Clinical Significance of Brachial-Ankle Pulse Wave Velocity in Type 2 Diabetes Mellitus Patients

Kaur

Kapoor³

et al. 2017

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Assessment of Metabolic Syndrome and Clinical Significance of Brachial-Ankle Pulse Wave Velocity in Type 2 Diabetes Mellitus Patients

Kaur

Kapoor³

et al. 2017

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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“…We also have demonstrated that overweightness is closely associated with development of metabolic syndrome (MetS) in mammalians, which is basically characterized with increased body-mass, increased blood glucose and serum insulin levels, marked MetS in mammalians is associated with a generalized metabolic disorder characterized with insulin resistance, increased body weight, significant high blood glucose and serum insulin levels, markedly increased systolic and diastolic blood pressures (Dutta et al 2001;Isomaa et al 2001;Okatan et al 2015). Our previous studies and others emphasize that MetS is also characterized with increased oxidative stress, due to an imbalance between production and scavenging of oxidants (Bhatti et al 2016;Bonomini et al 2015;Gregorio et al 2016;Okatan et al 2015;Vendemiale et al 1995), which also play important role in the pathogenesis of various diseases including MetS (Bonomini et al 2015;Roberts and Sindhu 2009). Similar to other studies (Galassetti 2012;Korkmaz et al 2013;Okatan et al 2015), our findings, related with significantly increased total oxidative status (TOS) and decreased total antioxidant status (TAS) in serum of MetS rats, support these statements.…”

Section: Discussionmentioning

confidence: 99%

Onset of decreased heart work is correlated with increased heart rate and shortened QT interval in high-carbohydrate fed overweight rats

Durak

Olğar

Tuncay

et al. 2017

Can. J. Physiol. Pharmacol.

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Mechanical activity of the heart is adversely affected with metabolic syndrome (MetS) characterized with increased body-mass and marked insulin-resistance.Herein, we examined effects of high-carbohydrate intake on cardiac functional abnormalities via evaluating in situ heart-work, heart-rate and electrocardiograms (ECG) in rats. MetS is induced in Wistar male rats by adding 32% sucrose for 22-24 weeks and confirmed with insulin-resistance, increased body-weight, blood glucose and insulin, systolic and diastolic blood pressures besides significant left ventricular integrity-lost and increased connective-tissue around myofibrils. Analysis of in situ ECG-recordings showed markedly shorten QT-interval and depressed QRP with increased heart-rate. We also observed augmented oxidative stress and decreased antioxidant defense characterized with decreases in serum total thiol-level and attenuated paraoxonase and arylesterase activities. Our data clearly indicate that increased heart-rate and shortened QT-interval concomitant with higher left ventricular developed pressure responses to β-adrenoreceptor stimulation as a result of less cAMP-release could be regarded as natural compensation mechanisms in overweight MetS rats. Since MetS leads further to persistent insulin-resistance and obesity, one should get into consideration these important facts associated with onset of the depressed heart-work, the increased heart-rate and shorten QT-interval in highcarbohydrate intake, which will possible lead to more deleterious effects on mammalian heart.

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“…All these subjects were a part of our ongoing study on diabetes and CVD [12]. In brief, this study was launched in year 2011 to inspect the susceptibility genes and their association with the pathophysiology of metabolic disorders, including type 2 diabetes and CVDs, in an Asian Indian population.…”

Section: Methodsmentioning

confidence: 99%

Paraoxonase 1 Gene Polymorphisms (Q192R and L55M) Are Associated with Coronary Artery Disease Susceptibility in Asian Indians

Kaur

Bhatti

Vijayvergiya

et al. 2018

Dubai Diabetes Endocrinol J

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Background: Coronary artery disease (CAD) is a complex metabolic disorder in which lifestyle and genetic factors are known to play key roles in pathogenesis. The paraoxonase 1 (PON1) enzyme has a defensive effect against CAD progression, as it safeguards low-density lipoproteins (LDLs) from oxidative modifications. The most extensively studied genetic variants in the PON1 gene are Q192R and L55M, which have been related with LDL antioxidative activity and risk of CAD. Objective: The present case-control study intended to examine the Q192R and L55M polymorphisms and their association with the risk of CAD patients in north Indians. Methods: A total of 872 subjects (412 CAD patients and 460 controls) were recruited from north India. The PON1 gene was amplified and genotypes were studies using PCR-RFLP. χ² analysis was performed to compare genotype/allele frequencies in patients and controls. Results: The present study indicated abdominal obesity, elevated body mass index, and dyslipidemia with increased levels of total cholesterol and triglycerides as well as reduced high-density lipoprotein cholesterol in CAD subjects compared to healthy controls (p < 0.05). Logistic regression analysis of the data revealed an association of the RR genotype of the Q192R polymorphism with an about 2-fold elevated risk of CAD (OR = 2.23, 95% CI = 1.47–3.37, p = 0.0001). Contrariwise, the L55M polymorphism did not show significant association with CAD (OR = 1.81, 95% CI = 0.66–4.95, p = 0.326). Conclusions: The Q192R polymorphism in the PON1 gene may be a susceptibility gene associated with increased risk of CAD in an Asian Indian population.

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Metabolic syndrome and risk of major coronary events among the urban diabetic patients: North Indian Diabetes and Cardiovascular Disease Study—NIDCVD-2

Cited by 43 publications

References 35 publications

Assessment of Metabolic Syndrome and Clinical Significance of Brachial-Ankle Pulse Wave Velocity in Type 2 Diabetes Mellitus Patients

Assessment of Metabolic Syndrome and Clinical Significance of Brachial-Ankle Pulse Wave Velocity in Type 2 Diabetes Mellitus Patients

Onset of decreased heart work is correlated with increased heart rate and shortened QT interval in high-carbohydrate fed overweight rats

Paraoxonase 1 Gene Polymorphisms (Q192R and L55M) Are Associated with Coronary Artery Disease Susceptibility in Asian Indians

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