Metabolic syndrome and the risk for recurrent pre‐eclampsia: a retrospective cohort study

Stekkinger, Eva; Scholten, Ralph R.; Vlugt, Maureen J. van der; Dijk, Arie P.J. van; Janssen, Mirian C. H.; Spaanderman, M.E.A.

doi:10.1111/1471-0528.12189

Cited by 33 publications

(31 citation statements)

References 34 publications

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“…8 On the other hand, a predisposition to the metabolic syndrome may induce women to develop preeclampsia during pregnancy. [9][10][11] Several studies have shown an association between maternal preeclampsia and elevated blood pressure (BP) in the offspring during childhood and adolescence. [12][13][14][15][16][17][18][19] Other studies have reported on glucose metabolism in the offspring of mothers with preeclampsia.…”

Section: Resultsmentioning

confidence: 99%

Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies

Seppä

Voutilainen

Tenhola

2015

The Journal of Pediatrics

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Section: Resultsmentioning

confidence: 99%

Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies

Seppä

Voutilainen

Tenhola

2015

The Journal of Pediatrics

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“…For example, increased oxidative stress is seen in diabetes mellitus, hypertension and coronary heart disease insulin resistance (75,76), hypertension, elevated levels of pro-inflammatory cytokines (79,80) and incidence of type 2 diabetes mellitus is high in them (81,82). This indicates that preeclampsia is a disease in which factors that are involved in the pathogenesis of insulin resistance, hypertension, type 2 diabetes mellitus and low-grade systemic inflammation play a significant role.…”

Section: Angiotensin-1 Receptor In Pre-eclampsiamentioning

confidence: 99%

Cytokines, angiogenic, and antiangiogenic factors and bioactive lipids in preeclampsia

Das¹

2015

Nutrition

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“…11 Recently there has been a study which demonstrates that inter-pregnancy metabolic syndrome predisposes to preeclampsia which further substantiates the fact that these two disorders share a common pathophysiology. 12 By elucidating the association of metabolic syndrome with severity of preeclampsia it may be possible to understand the pathophysiology and potentially predict the development of severe pre-eclampsia.…”

Section: Introductionmentioning

confidence: 84%

Prevalence of metabolic syndrome in preeclampsia

Beigh

Naik

Tali

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONPre-eclampsia is defined as new onset of hypertension and proteinuria after 20th weeks of gestation in a previously normotensive woman and it complicates 2-8% of pregnancies and contributes to considerable maternal, neonatal morbidity and mortality.1-3 The majority of maternal deaths during pregnancy are caused by medical disorders and hypertension being the commonest cause. 4 The aetiology of preeclampsia remains unknown despite continued medical research. The pathophysiology of preeclampsia likely involves both maternal and fetal/placental factors although more with the former.The risk of abnormal placentation and preeclampsia is the result of medical conditions associated with vascular ABSTRACT Background: Preeclampsia is associated with increased morbidity and mortality and it increases with severity of preeclampsia. Preeclampsia shares many characteristics of metabolic syndrome (MeS) which has led many investigators to elucidate this relationship. The aim and objective of this study was to assess the prevalence of MS in preeclampsia and its relation with its severity. Methods: The study included 130 cases (41 gestational hypertension (GHTN), 27 mild pre-eclampsia (Mild PET), 47 severe preeclampsia (Severe PET), 13 pre-eclampsia superimposed on chronic hypertension (PSHTN) and 2 eclampsia) based on pre-specified maternal characteristics according to ACOG criteria after 20 th week of gestation. Two hundred normotensive pregnant females served as controls. The frequency of MS was assessed using pregnancy adaptation of MeS definition of the NCEP-ATP III criteria in cases and controls. Results: Metabolic syndrome was found in 37.7% of preeclampsia group and 12% of control group (p<0.00). Among the components of MeS, preeclampsia group was having significantly higher sugars (30% Vs 20%) and body mass index (BMI) (23.8% Vs 7.5%) than controls. GHTN was seen in 31.5%, mild PET in 20.8%, severe PET in 36.2%, PSHTN in 10% and eclampsia in 1.5% of cases. MeS was seen in 57.4% of severe PET, 50% of eclampsia, 26.8% of GHTN, 25.9% of mild PET and 23.1% of PSHTN. The clinical course in preeclampsia with MeS was complicated by IUD (intrauterine death), IUGR (intrauterine growth retardation), preterm delivery, APH and pulmonary edema. Oligohydromnios was less common in preeclampsia with MeS. Conclusions: The frequency of MeS was higher in preeclampsia group as compared to normotensive group. MeS was more significantly higher in patients with severe preeclampsia. In our study there were no demographic, clinical and laboratory predictors of MeS in preeclampsia. On the other hand, preeclampsia patients with MeS had significant maternofoetal complications. There is a need to screen for MeS in pregnant females from the first antenatal visit in order to predict severe preeclampsia.

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Metabolic syndrome and the risk for recurrent pre‐eclampsia: a retrospective cohort study

Abstract: Interpregnancy metabolic syndrome predisposes to recurrent pre-eclampsia.

Cited by 33 publications

References 34 publications

Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies

Markers of Insulin Sensitivity in 12-Year-Old Children Born from Preeclamptic Pregnancies

Cytokines, angiogenic, and antiangiogenic factors and bioactive lipids in preeclampsia

Prevalence of metabolic syndrome in preeclampsia

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