Metabolic Syndrome Characteristics in Gout Patients

Fraile, José M.; Torres, Rosa J.; Miguel, M.; Martínez, Pedro Martínez; Lundelin, Krista; Vázquez, Juan José; Puig, Juan

doi:10.1080/15257771003738709

Cited by 15 publications

(13 citation statements)

References 11 publications

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“…Pathological change can be prevented with allopurinol, a uric acid lowering drug 14 . In humans, hyperuricaemia is associated with the metabolic syndrome and all the individual components of the metabolic syndrome 15–17 . Hyperuricaemia is also an independent risk factor for renal disease, myocardial infarction and stroke 18,19 .…”

Section: Introductionmentioning

confidence: 99%

“…14 In humans, hyperuricaemia is associated with the metabolic syndrome and all the individual components of the metabolic syndrome. [15][16][17] Hyperuricaemia is also an independent risk factor for renal disease, myocardial infarction and stroke. 18,19 The observations in animals, along with the epidemiological evidence from humans, implicate hyperuricaemia as a potentially significant contributor to vascular and cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

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Systematic review of the prevalence of gout and hyperuricaemia in Australia

Robinson

Taylor

Merriman

2012

Internal Medicine Journal

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Aims: Gout is a growing health problem worldwide especially in affluent countries, such as Australia. Gout and hyperuricaemia are associated with the metabolic syndrome, diabetes mellitus, obesity and hypertension. More importantly, Australia has a growing prevalence of these important health problems. The aim of this study was to systematically review published information regarding the prevalence of gout and hyperuricaemia in Australia. Methods: A systematic search was undertaken of the MEDLINE, EMBASE and Web of Science databases, as well as relevant websites for journal articles and reports relating to the prevalence of hyperuricaemia and gout in Australia. Results: Twenty‐five journal articles and five reports were included in the review. Data collected in a standardised way show gout increased in prevalence from 0.5% population prevalence to 1.7% population prevalence from 1968 to 1995/1996. There has been a significant rise in the prevalence of gout in the Australian Aboriginal population from 0% in 1965 to 9.7% in men and 2.9% in women in 2002. Consistent with the rise in gout prevalence, serum uric acid in blood donors has increased from 1959 to 1980 (17% in 30‐ to 40‐year‐old men). Conclusions: The rate of gout and hyperuricaemia in Australia is high in relation to comparable countries and is increasing. The prevalence of gout in elderly male Australians is second only to New Zealand, which has the highest reported rate in the world. Further research on Aboriginal and Torres Strait Islander gout and hyperuricaemia is required as a result of the lack of contemporary data.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systematic review of the prevalence of gout and hyperuricaemia in Australia

Robinson

Taylor

Merriman

2012

Internal Medicine Journal

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“…Посматран је 41 пацијент са примарним гихтом, а више од половине испитаника (51%) имало је више од три удружене манифестације. Заступљеност према удруженим болестима била је: гојазност (21/41), хипертензија (30/41), дислипидемија (30/41), дијабетес мелитус (22/41), што отежава лечење гихта (14).…”

Section: материјал и метод радаunclassified

Effects of associated diseases in gout and influence on course and treatment

Vasić¹,

Zvekic-Svorcan²,

Filipovic³

et al. 2012

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Сажетак Увод. Познато је да су неке болести и патолошка стања чешће присутни код болесника са гихтом него у осталој популацији. До данас нису тачно утврђени разлози за ову повезаност, али је сигурно да удружене болести погоршавају прогнозу гихта. Циљ. Утврђивање утицаја удружених болести у гихту на његов ток и лечење. Материјал и метод. Ретроспективном анализом обухваћено је 168 болесника, оба пола, различите старосне доби, оболелих од уратног артритиса, а лечених у Специјалној болници за реуматске болести у Новом Саду од 2008. до 2011. године. Код свих пацијената су праћене друге придружене болести (хипертензија, дијабетес мелитус, гојазност, хиперхолестеролемија са хипертриглицеридемијом и атеросклероза). Из студије су били искључени сви пацијенти који имају дијагностиковану реналну инсуфицијенцију. Резултати. Највећи број испитаника чинили су мушкарци (89%). Више од половине испитаника (54%) имали су 2 и 3 гихтична напада. Најзаступљеније придружене болести су хиперхолестеролемија, затим хипертензија, гојазност, дијабетес мелитус и атеросклероза. Највећи број оболелих од гихта имало је више од 3 придружене болести (67% пацијената), што је резултовано већим бројем атака. Закључак. Учесталост гихтичних напада је у функцији времена трајања болести, у току које Summаry Introduction. It is well known that some diseases and pathological conditions are more frequent in patients with gout than in general population. Till this date is unclear why, but associated diseases negatively affect gout disease and its future prognosis. Aim. Determining the impact of joint diseases on gout and the course of the treatment. Materials and method. Retrospective analysis included 168 patients of both sexes, different ages, uric arthritis patients, which were treated in a Special Hospital for Rheumatic Diseases in Novi Sad from 2008 to 2011. All patients were monitored for other associated diseases (hypertension, diabetes mellitus, obesity, hypercholesterolemia with hypertriglyceridemia and atherosclerosis). This study excluded all patients diagnosed with renal insufficiency. Results. The majority of patients were males, 89%. More than half of patients (54%) had 2 and 3 gout attacks. The most common associated disease was hypercholesterolemia, followed by hypertension, obesity, diabetes mellitus and atherosclerosis. Most patients had more than three associated diseases (67% of them), which resulted in inreased number of attacks. Conclusion. Gout attacks frequency is progressive with time, during which its number increases, correlating the number of associated events. Hence

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“…Gout, which is a chronic and systemic inflammatory arthritis caused by hyperuricemia, has been found to be associated with metabolic syndrome34. The presence of metabolic syndrome (MS) is also associated with a higher prevalence of cardiovascular disease5678 However, the prevalence of gout has been increasing worldwide910111213.…”

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confidence: 99%

The risk of atrial fibrillation in patients with gout: a nationwide population-based study

Kuo

Tsai

Chang

et al. 2016

Sci Rep

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Many studies have found that systemic inflammation plays an important role in the pathogenesis of atrial fibrillation (AF). Gout is a chronic systemic inflammatory disorder, but little evidence exists regarding whether the risk of AF is increased in patients with gout. The National Health Insurance Research Database in Taiwan was used in this study, and gout was defined as the occurrence of at least one episode of an acute gout attack requiring medical treatment. A total of 63264 gout and 63264 age- and gender-matched patients were included as the study population. The Cox model was used to evaluate the risk of AF in patients with gout. Patients with gout experienced a greater frequency of co-morbidities compared to patients without gout. The cumulative incidences of AF were 4.61% and 3.04% in patients with and without gout, respectively (log-rank test, P < 0.001). After adjusting for co-morbidities and prescription medication use, gout was found to be associated with AF [hazard ratio (HR), 1.38]. Moreover, the HR for AF decreased with increasing age in our study. Gout was found to be associated with an increased risk of developing AF after adjusting for potential confounders.

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Metabolic Syndrome Characteristics in Gout Patients

Cited by 15 publications

References 11 publications

Systematic review of the prevalence of gout and hyperuricaemia in Australia

Systematic review of the prevalence of gout and hyperuricaemia in Australia

Effects of associated diseases in gout and influence on course and treatment

The risk of atrial fibrillation in patients with gout: a nationwide population-based study

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