Metabolic Syndrome, Cognitive Impairment and the Role of Diet: A Narrative Review

Kouvari, Matina; D’Cunha, Nathan M.; Travica, Nikolaj; Sergi, Domenico; Zec, Manja; Marx, Wolfgang; Naumovski, Nenad

doi:10.3390/nu14020333

Cited by 38 publications

(30 citation statements)

References 174 publications

(189 reference statements)

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“…On the other hand, it was shown that cognitive impairment is also associated with metabolic syndrome ( 48 ). In fact, CVD and cerebrovascular disease may share underlying mechanisms and risk factors ( 49 ).…”

Section: Discussionmentioning

confidence: 99%

Identifying latent comorbidity patterns in adults with perceived cognitive impairment: Network findings from the behavioral risk factor surveillance system

Ramos-Vera

Saintila

O'Diana

et al. 2022

Front. Public Health

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BackgroundPeople with cognitive impairment may be exposed to an increased risk of comorbidities; however, the clustering of comorbidity patterns in these patients is unclear.ObjectiveTo explore the network structure of chronic comorbidity in a U.S. national sample spanning all 50 U.S. states with more than 170,000 participants reporting perceived cognitive impairment.MethodsThis is a cross-sectional study conducted using Behavioral Risk Factor Surveillance System (BRFSS) secondary data collected in 2019 and covering 49 U.S. states, the District of Columbia, Guam, and the Commonwealth of Puerto Rico. A total of 15,621 non-institutionalized U.S. adult participants who reported “yes” to the subjective cognitive impairment question were considered, of whom 7,045 were men and 8,576 were women. All participants were aged 45 years or older. A statistical graphical model was used that included clustering algorithms and factorization of variables in a multivariate network relationship system [exploratory graphical analysis (EGA)].ResultsThe results of the EGA show associations between the comorbid conditions evaluated. These associations favored the clustering of various comorbidity patterns. In fact, three patterns of comorbidities have been identified: (1) arthritis, asthma, respiratory diseases, and depression, (2) obesity, diabetes, blood pressure high, and blood cholesterol high, and (3) heart attack, coronary heart disease, stroke, and kidney disease.ConclusionThese results suggest the development of interdisciplinary treatment strategies in patients with perceived cognitive impairment, which could help to design an integrated prevention and management of the disease and other related health problems, such as Alzheimer's disease and related dementias.

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Section: Discussionmentioning

confidence: 99%

Identifying latent comorbidity patterns in adults with perceived cognitive impairment: Network findings from the behavioral risk factor surveillance system

Ramos-Vera

Saintila

O'Diana

et al. 2022

Front. Public Health

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“…43 Dyslipidemia from a high-fat diet can contribute to the development of atherosclerotic plaque, leading to microvascular dysfunction, associated with worse cognitive performance. 44 Higher intake of SFAs was associated with a 15% to 19% increased risk of impairment in memory, psychomotor speed, and cognitive flexibility. 45 Accuracy on both the relational and item tests was better with a low intake of SFAs in children.…”

Section: Lower Dietary Sfas Contribute To Improved Cognition and Redu...mentioning

confidence: 97%

Reducing excess dietary saturated fat intake to improve cognition in vascular dementia

Blake¹,

Harding²,

Blake³

et al. 2022

GSC Adv. Res. Rev.

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Reducing excess dietary saturated fatty acids (SFAs) may be a therapy to slow cognitive decline in vascular dementia (VaD). It has been well established that lower levels of dietary SFAs reduce risk of cognitive decline and vascular dementia. In patients who consume high amounts of SFAs, limiting intake of SFAs could improve cognition. Some trials have seen a reduction in atherosclerotic lesions and memory problems with diets reduced in total and saturated fat. It has also been well established that excess dietary SFAs increase serum cholesterol and risk of atherosclerosis, so reducing dietary SFAs could reduce arterial clogging, potentially improving perfusion and cognition. Many studies show that those with lower dietary SFAs have decreased blood-brain barrier damage and neuroinflammation, so reducing excess dietary SFAs could reduce neuroinflammation. Excess dietary SFAs impair neurovascular coupling, potentially leading to brain pathologies ranging from subtle cognitive deficits to severe dementia. Studies on stroke survivors show that limiting the consumption of SFAs improves cognitive functions after stroke. We will show that reducing excess dietary SFAs can produce protective effects on cognitive functioning. More studies are needed to determine if reducing excess dietary SFAs can improve memory and other cognitive functioning in those with vascular dementia.

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“…Diet plays a critical role in the prevention of metabolic syndromes such as diabetes, cancer, and chronic diseases related with ageing [ 29 , 30 ]. Marine algae-derived bioactive metabolites, such as amino acids, peptides, fatty acids, lipids, carbohydrates, polysaccharides, sterols, polyphenols, photosynthetic pigments, carrageenan, agar, fucoidan, laminaran, naviculan, vitamins, and minerals, exert a persuasive antioxidant activity that has a beneficial effect in fighting the aforementioned diseases [ 5 ].…”

Section: Diversity Of Bioactive Metabolites and Their Potential Healt...mentioning

confidence: 99%

Cyanobacteria and Algae-Derived Bioactive Metabolites as Antiviral Agents: Evidence, Mode of Action, and Scope for Further Expansion; A Comprehensive Review in Light of the SARS-CoV-2 Outbreak

et al. 2022

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COVID-19—a severe acute respiratory syndrome disease caused by coronavirus 2 (SARS-CoV-2)—has recently attracted global attention, due to its devastating impact, to the point of being declared a pandemic. The search for new natural therapeutic drugs is mandatory, as the screening of already-known antiviral drugs so far has led to poor results. Several species of marine algae have been reported as sources of bioactive metabolites with potential antiviral and immunomodulatory activities, among others. Some of these bioactive metabolites might be able to act as antimicrobial drugs and also against viral infections by inhibiting their replication. Moreover, they could also trigger immunity against viral infection in humans and could be used as protective agents against COVID-In this context, this article reviews the main antiviral activities of bioactive metabolites from marine algae and their potential exploitation as anti-SARS-CoV-2 drugs.

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Metabolic Syndrome, Cognitive Impairment and the Role of Diet: A Narrative Review

Cited by 38 publications

References 174 publications

Identifying latent comorbidity patterns in adults with perceived cognitive impairment: Network findings from the behavioral risk factor surveillance system

Identifying latent comorbidity patterns in adults with perceived cognitive impairment: Network findings from the behavioral risk factor surveillance system

Reducing excess dietary saturated fat intake to improve cognition in vascular dementia

Cyanobacteria and Algae-Derived Bioactive Metabolites as Antiviral Agents: Evidence, Mode of Action, and Scope for Further Expansion; A Comprehensive Review in Light of the SARS-CoV-2 Outbreak

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