Metabolic Syndrome: Consensus and Controversy: State of the Art

Tavares, Hamilton dos Prazeres; Gelaleti, Rafael Bottaro; Picolo, Fernanda; Tavares, Suelma Beatriz Marques Prata; Marini, Gabriela; Abbade, Joélcio Francisco; Santos, Débora Cristina Damasceno Meirelles dos; Campos, Pablo; Calderon, Iracema de matos Paranhos; Rudge, Marilza Vieira Cunha

doi:10.4236/ojemd.2015.59016

Cited by 3 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its low economical cost and availability have increased its usage than glucose in our industries today [34]. Different associations and international bodies have been trying to diagnose and find the reasons behind the sudden rise in the mortality rate caused by this syndrome, but there is no diagnostic measure specific to the syndrome [35] Oxidative stress: feedback effect of fructose consumption The consumption of dietary fructose which is known as sweetened foods is now prevalent in our society today. the behaviour of human beings and the industrialised world in modifying the human diet with sweetened power to prolong shelf life of food has played vital role in the ingestion of high fructose diets as well as the prevalence of metabolic abnormalities [4,5].…”

Section: High Fructose Consumption and Body Complicationsmentioning

confidence: 99%

High Fructose Consumption: More Pain Than Gain to Human Health

Isaiah¹,

Olanrewaju²,

Sholeye³

et al. 2021

Preprint

View full text Add to dashboard Cite

An imbalance in any metabolic system can be traced to its homeostasis. When homeostatic environment is not attainable then there will be a response from the body. A new shift has emerged, “the negative feedback effect of high fructose consumption;” more pain than gain. The human metabolic system daily combat fructose sugar metabolism which emanates from high consumption. This inadvently lead to a chronological series of complications arising from the feedback. These feedbacks play pivotal roles in skeletal muscle damage and other body frameworks, it also fosters toxic advanced glycation end products (AGEs), factors that impose and inflict damaging effects to the body`s energy currency and serious threat to health. These damages are missed or overlooked because of early nonspecific physiological symptoms. High level of fructose has both long- and short-term effects on human metabolic processes. These effects which are majorly through the production of reactive oxygen species (ROS) and other free radicals, are felt in the disruption of biomolecules such as causing DNA mutation, lipid peroxidation etc. these effects in turn lead to various diseases such as cancer, diabetes, atherosclerosis, and other health issues. In this review, we will focus on the damaging effects this sugar has on human health and the present solutions being applied. We will also look at the next step in combatting and controlling these negative feedbacks.

show abstract

Section: High Fructose Consumption and Body Complicationsmentioning

confidence: 99%

High Fructose Consumption: More Pain Than Gain to Human Health

Isaiah¹,

Olanrewaju²,

Sholeye³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: A randomised, double-blind, placebo-controlled feasibility trial

et al. 2018

View full text Add to dashboard Cite

Chronic hypertension in pregnancy is associated with significant adverse pregnancy outcomes, increasing the risk of pre-eclampsia, fetal growth restriction and preterm birth. Dietary nitrate, abundant in green leafy vegetables and beetroot, is reduced in vivo to nitrite and subsequently nitric oxide, and has been demonstrated to lower blood pressure, improve vascular compliance and enhance blood flow in non-pregnant humans and animals. The primary aims of this study were to determine the acceptability and efficacy of dietary nitrate supplementation, in the form of beetroot juice, to lower blood pressure in hypertensive pregnant women. In this double-blind, placebo-controlled feasibility trial, 40 pregnant women received either daily nitrate supplementation (70 mL beetroot juice, n = 20) or placebo (70 mL nitrate-depleted beetroot juice, n = 20) for 8 days. Blood pressure, cardiovascular function and uteroplacental blood flow was assessed at baseline and following acute (3 h) and prolonged (8 days) supplementation. Plasma and salivary samples were collected for analysis of nitrate and nitrite concentrations and acceptability of this dietary intervention was assessed based on questionnaire feedback. Dietary nitrate significantly increased plasma and salivary nitrate/nitrite concentrations compared with placebo juice (p < 0.001), with marked variation between women. Compared with placebo, there was no overall reduction in blood pressure in the nitrate-treated group; however there was a highly significant correlation between changes in plasma nitrite concentrations and changes in diastolic blood pressure in the nitrate-treated arm only (r = -0.6481; p = 0.0042). Beetroot juice supplementation was an acceptable dietary intervention to 97% of women. This trial confirms acceptability and potential efficacy of dietary nitrate supplementation in pregnant women. Conversion of nitrate to nitrite critically involves oral bacterial nitrate reductase activities. We speculate that differences in efficacy of nitrate supplementation relate to differences in the oral microbiome, which will be investigated in future studies.

show abstract