Metabolic syndrome, endothelial injury, and subclinical atherosclerosis in patients with systemic lupus erythematosus

Mok, CC; Poon, WL; Lai, JPS; Chiu, SM; Ck, Wong; Lun, SWM; Ko, Gtc; Lam, C. W. K.; Lam, CS

doi:10.1080/03009740903046668

Cited by 19 publications

(27 citation statements)

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“…29,30 ). Lupus patients with metabolic syndrome had more often higher carotid IMT and higher Agatston calcium score as detected in coronary arteries by computed tomography scan, higher levels of hsCRP and homocysteine 31 . In another study on 162 lupus females, the prevalence of metabolic syndrome was 32.1% and was associated with negative course of disease with increased proteinuria, higher modified SLEDAI-2k activity score, worse damage index score (SLICC/ACR), and were more often treated with cyclophosphamide 32 .…”

Section: Discussionmentioning

confidence: 99%

Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Smrzova¹,

Horák²,

Skácelová³

et al. 2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aim. Accelerated atherosclerosis in systemic lupus erythematosus (SLE) is an important cause of morbidity and mortality. The pathophysiology of accelerated atherosclerosis in SLE is mediated by factors such as inflammatory processes in the vascular wall, specific antibodies, dyslipoproteinemia, endothelial dysfunction and the high prevalence of traditional risk factors for cardiovascular diseases. In this context, we evaluated the clinical significance of ultrasound examination of the carotic arteries in the early diagnosis of atherosclerosis. Methods. The study included 63 patients with SLE (female: male 53:10, mean age 38.4±12.7 years, mean disease duration 143.0 ±82.6 months), 24 patients had lupus nephritis. The control group consisted of 24 volunteers (female: male 20:4 mean age 31.04±8.59). Intima media thickness (IMT) was measured by ultrasound on both sides. The results were correlated with markers of lipid spectrum, anti-dsDNA, antinucleosomal and anticardiolipin antibodies, lupus anticoagulant and complement components. Clinical disease activity and damage were evaluated by SLEDAI and SLICC indices. Lifestyle and other important factors were examined per protocol and by questionnaire. Results. A significant difference of IMT (P≤0.03) was found between the lupus patients and sex-age adjusted healthy controls with an in mean IMT in SLE patients of 0.569±0.11 mm, in control group 0.495±0.05 mm. A significant correlation between IMT and disease duration, age, positivity of lupus anticoagulant, use of ACE inhibitors, glomerular filtration and serum creatinine were found. No difference in IMT was found between patients with or without lupus nephritis. Conclusion. IMT measurement could be used as a clinical predictor of risk of accelerated atherosclerosis in lupus patients.

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Section: Discussionmentioning

confidence: 99%

Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Smrzova¹,

Horák²,

Skácelová³

et al. 2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Circulating levels of TM are typically in the low nanogram per milliliter range in healthy human subjects, with pathology frequently causing a moderate, but significant, 1.5-to 2.0-fold increase in patient plasma TM levels (38, 90,105,130,178). While these TM levels are probably too low to have a significant impact on coagulation processes, the consistent elevation in circulating TM levels during pathologies is now widely regarded as an important circulatory biomarker for endothelial dysfunction and vascular risk assessment (15).…”

Section: Posttranslational Regulationmentioning

confidence: 99%

Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects

Martin

Murphy

Cummins

2013

American Journal of Physiology-Heart and Circulatory Physiology

180

163

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“…Metabolic syndrome, endothelial injury, and subclinical atherosclerosis in patients with systemic lupus erythematosus: comments on the article by Mok et al Letters Letters We read with interest the report of Mok et al (1) in which the authors demonstrate a significant association between coronary atherosclerosis and metabolic syndrome (MetS) in systemic lupus erythematosus (SLE) patients. They state that there were no data regarding atherosclerosis and MetS in SLE previous to their article.…”

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confidence: 55%

Erratum

2010

Scandinavian Journal of Rheumatology

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Metabolic syndrome, endothelial injury, and subclinical atherosclerosis in patients with systemic lupus erythematosus

Cited by 19 publications

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Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects

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