Metabolic syndrome, endothelial injury, and subclinical atherosclerosis in patients with systemic lupus erythematosus: comments on the article by Mok et al

Sabio, JA; Vargas-Hitos, JA; Mario, Juan

doi:10.3109/03009742.2010.489907

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…In the same way, Ugolini-Lopes et al 24 found that serum uric acid levels <6.05 mg/dL at 12 months of follow-up were a predictor of good long-term renal outcome in lupus nephritis. Likewise, in the study by Sabio et al ,25 patients with hyperuricaemia presented a worse cardiovascular risk profile that included hypertension, obesity, high cholesterol levels, renal damage and metabolic syndrome; in addition, serum uric acid levels correlated with high levels of erythrocyte sedimentation rate, C reactive protein, fibrinogen and homocysteine. Similarly, Castillo-Martínez et al 8 demonstrated that serum uric acid levels greater than 7 mg/dL would increase the risk of developing pulmonary hypertension by 8.5 times 8.…”

Section: Discussionmentioning

confidence: 86%

Serum uric acid is associated with damage in patients with systemic lupus erythematosus

et al. 2020

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IntroductionSerum uric acid levels have been reported as predictors of cardiovascular, pulmonary, neurological and renal morbidity in patients with SLE. However, their role in cumulative global damage in these patients has not yet been determined.ObjectiveTo determine whether serum uric acid levels are associated with new damage in patients with SLE.MethodsThis is a longitudinal study of patients with SLE from the Almenara Lupus Cohort, which began in 2012. At each visit, demographic and clinical characteristics were evaluated, such as activity (Systemic Lupus Erythematosus Disease Activity Index-2K or SLEDAI-2K) and cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index or SDI). Treatment (glucocorticoids, immunosuppressive drugs and antimalarials) was also recorded. Univariable and multivariable Cox regression models were used to determine the impact of serum uric acid levels on the risk of new damage.ResultsWe evaluated 237 patients, with a mean age (SD) at diagnosis of 35.9 (13.1) years; 220 patients (92.8%) were women, and the duration of the disease was 7.3 (6.6) years. The mean SLEDAI-2K and SDI scores were 5.1 (4.2) and 0.9 (1.3), respectively. Serum uric acid level was 4.5 (1.4) mg/dL. Follow-up time was 3.1 (1.3) years, and 112 (47.3%) patients accrued damage during follow-up. In univariable and multivariable analyses, serum uric acid levels were associated with new damage (HR=1.141 (95% CI 1.016 to 1.282), p=0.026; HR=1.189 (95% CI 1.025 to 1.378), p=0.022, respectively).ConclusionHigher serum uric acid levels are associated with global damage in patients with SLE.

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Section: Discussionmentioning

confidence: 86%

Serum uric acid is associated with damage in patients with systemic lupus erythematosus

et al. 2020

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“…Kiani et al [55] showed that increasing age was independently associated with the progression of cIMT over a 2-year period, while Sabio et al [56][57][58][59][60] showed that increased PWV was associated with increased age. Salmon et al [18] showed that older age at diagnosis, longer duration of SLE, and higher homocysteine concentration are independently related to the progression of atherosclerosis in SLE.…”

Section: Agementioning

confidence: 99%

Why are kids with lupus at an increased risk of cardiovascular disease?

2015

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Juvenile-onset systemic lupus erythematosus (SLE) is an aggressive multisystem autoimmune disease. Despite improvements in outcomes for adult patients, children with SLE continue to have a lower life expectancy than adults with SLE, with more aggressive disease, a higher incidence of lupus nephritis and there is an emerging awareness of their increased risk of cardiovascular disease (CVD). In this review, we discuss the evidence for an increased risk of CVD in SLE, its pathogenesis, and the clinical approach to its management.

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“…While MKK4 and MKK7 are the main activators of JNKs, the p38 pathway is triggered primarily by MKK3 and MKK6 [43]. There are three JNK kinases (JNK1, JNK2 and JNK3 [44]), whereas p38 isoforms consist of p38α, p38β, p38γ/SAPK3 and p38δ/SAPK4 [43] (Fig. 1).…”

Section: Stress Kinases and Energy Metabolismmentioning

confidence: 99%

Brain JNK and metabolic disease

Nogueiras

Sabio

2020

Diabetologia

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Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with central insulin and leptin resistance. This central action of nutrient overload appears very rapidly, suggesting that nutrition-induced hypothalamic stress is a major upstream initiator of obesity and associated diseases. The cellular response to nutrient overload includes the activation of the stress-activated c-Jun N-terminal kinases (JNKs) JNK1, JNK2 and JNK3, which are widely expressed in the brain. Here, we review recent findings on the regulation and effects of these kinases, with particular focus on the hypothalamus, a key brain region in the control of energy and glucose homeostasis. JNK1 blocks the hypothalamic-pituitary-thyroid axis, reducing energy expenditure and promoting obesity. Recently, opposing roles have been identified for JNK1 and JNK3 in hypothalamic agouti gene-related protein (AgRP) neurons: while JNK1 activation in AgRP neurons induces feeding and weight gain and impairs insulin and leptin signalling, JNK3 (also known as MAPK10) deletion in the same neuronal population produces very similar effects. The opposing roles of these kinases, and the unknown role of hypothalamic JNK2, reflect the complexity of JNK biology. Future studies should address the specific function of each kinase, not only in different neuronal subsets, but also in non-neuronal cells in the central nervous system. Decoding the puzzle of brain stress kinases will help to define the central stimuli and mechanisms implicated in the control of energy balance.

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Metabolic syndrome, endothelial injury, and subclinical atherosclerosis in patients with systemic lupus erythematosus: comments on the article by Mok et al

Cited by 3 publications

References 4 publications

Serum uric acid is associated with damage in patients with systemic lupus erythematosus

Serum uric acid is associated with damage in patients with systemic lupus erythematosus

Why are kids with lupus at an increased risk of cardiovascular disease?

Brain JNK and metabolic disease

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