Metabolic syndrome in 10–16-year-old learners from the Western Cape, South Africa: Comparison of the NCEP ATP III and IDF criteria

Matsha, Tandi E.; Hassan, Shafick M; Bhata, A.; Yako, Yandiswa Y; Fanampe, Biotumelo L; Somers, Anne R.; Hoffmann, Monika; Mohammed, Zahraa; Erasmus, R T

doi:10.1016/j.atherosclerosis.2009.01.030

Cited by 15 publications

(16 citation statements)

References 17 publications

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“…In some cases many complications associated with obesity are already evident in childhood, necessitating commitment to lifelong treatments at an earlier age. We have previously reported a high prevalence of metabolic syndrome (MetS) in obese and overweight children from South Africa [3]. Central obesity and insulin resistance are dominant features of MetS.…”

Section: Introductionmentioning

confidence: 99%

Optimal Waist-to-Height Ratio Values for Cardiometabolic Risk Screening in an Ethnically Diverse Sample of South African Urban and Rural School Boys and Girls

et al. 2013

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BackgroundThe proposed waist-to-height ratio (WHtR) cut-off of 0.5 is less optimal for cardiometabolic risk screening in children in many settings. The purpose of this study was to determine the optimal WHtR for children from South Africa, and investigate variations by gender, ethnicity and residence in the achieved value.MethodsMetabolic syndrome (MetS) components were measured in 1272 randomly selected learners, aged 10–16 years, comprising of 446 black Africans, 696 mixed-ancestry and 130 Caucasians. The Youden’s index and the closest-top-left (CTL) point approaches were used to derive WHtR cut-offs for diagnosing any two MetS components, excluding the waist circumference.ResultsThe two approaches yielded similar cut-off in girls, 0.465 (sensitivity 50.0, specificity 69.5), but two different values in boys, 0.455 (42.9, 88.4) and 0.425 (60.3, 67.7) based on the Youden’s index and the CTL point, respectively. Furthermore, WHtR cut-off values derived differed substantially amongst the regions and ethnic groups investigated, whereby the highest cut-off was observed in semi-rural and white children, respectively, Youden’s index0.505 (31.6, 87.1) and CTL point 0.475 (44.4, 75.9).ConclusionThe WHtR cut-off of 0.5 is less accurate for screening cardiovascular risk in South African children. The optimal value in this setting is likely gender and ethnicity-specific and sensitive to urbanization.

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Section: Introductionmentioning

confidence: 99%

Optimal Waist-to-Height Ratio Values for Cardiometabolic Risk Screening in an Ethnically Diverse Sample of South African Urban and Rural School Boys and Girls

et al. 2013

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“…The prevalence of children with normal weight compares to similar studies that were conducted in the Western Cape, but less so to the studies that incorporated a countrywide sample. 36,37 It is likely that in our study, the differential prevalence of undernutrition according to gender was owing to a delay in pubertal growth in the adolescent boys, compared to that in the adolescent girls. This occurs when undernutrition is prevalent in a community.…”

Section: Discussionmentioning

confidence: 87%

“…40 This paper reports on the recently estimated prevalence of underweight, overweight and obesity in a randomly selected multiracial group of urban adolescent schoolchildren in the Cape Metropole area of Cape Town. The information updates that provided by Jinabhai et al 32 and Matsha et al, 36 and highlights the fact that in-depth studies are needed in the different regions of South Africa to improve an understanding of the weight to height ratio of specific groups of adolescents, based on demographics.…”

Section: Introductionmentioning

confidence: 97%

The prevalence of underweight, overweight and obesity in a multiracial group of urban adolescent schoolchildren in the Cape Metropole area of Cape Town

Niekerk

Grimmer

Louw

2014

South African Journal of Clinical Nutrition

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“…The study population of the ‘parent’ research project consisted of a total of 1,272 learners aged 10–16 years that were recruited through a proportionally stratified multistage random sampling technique from government-funded primary and secondary schools using a list of 107 schools obtained from the Western Cape Education Department [38]. …”

Section: Methodsmentioning

confidence: 99%

Association of Cocaine- and Amphetamine-Related Transcript, Leptin and Leptin Receptor Gene Polymorphisms with Anthropometric Obesity Phenotype Indicators in South African Learners

Yako

Fanampe²,

Hassan³

et al. 2011

Lifestyle Genomics

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Background/Aims: Obesity has increased rapidly in South African children and adolescents. Genes involved in appetite regulation have been extensively studied worldwide, but their role in the obesity phenotype in South African Black and mixed-ancestry school adolescents is unknown. Methods: Seven common polymorphisms in LEP, GHRL, CART and LEPR were analysed for genotype and haplotype association with anthropometric obesity phenotype indicators in South African Black and mixed-ancestry adolescent school learners. Results: The CART c.517A→G polymorphism was significantly associated with obesity susceptibility. The LEPR Lys¹⁰⁹Arg G allele was associated with an average reduction of 2.36 kg/m² in body mass index (BMI), 5.66 cm in waist circumference (WC) and 1.61 cm in mid-upper-arm circumference (MUAC). This was confirmed by haplotype analysis. Additionally, a haplotype of the LEP polymorphisms significantly increased BMI, MUAC and hip circumference, while LEPR haplotypes were associated with differences in MUAC. Conclusion: Our findings suggest that c.517A→G and Lys¹⁰⁹Arg contribute to the variation in anthropometric obesity phenotype indicators observed among Black African and mixed-ancestry South African learners. Furthermore, haplotypes of LEP, LEPR and GHRL polymorphisms were associated with varying measurements of weight, BMI and WC. Further studies are required to confirm our results in a larger and homogeneous study population group.

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Metabolic syndrome in 10–16-year-old learners from the Western Cape, South Africa: Comparison of the NCEP ATP III and IDF criteria

Cited by 15 publications

References 17 publications

Optimal Waist-to-Height Ratio Values for Cardiometabolic Risk Screening in an Ethnically Diverse Sample of South African Urban and Rural School Boys and Girls

Optimal Waist-to-Height Ratio Values for Cardiometabolic Risk Screening in an Ethnically Diverse Sample of South African Urban and Rural School Boys and Girls

The prevalence of underweight, overweight and obesity in a multiracial group of urban adolescent schoolchildren in the Cape Metropole area of Cape Town

Association of Cocaine- and Amphetamine-Related Transcript, Leptin and Leptin Receptor Gene Polymorphisms with Anthropometric Obesity Phenotype Indicators in South African Learners

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