Metabolic syndrome in antipsychotic naïve patients with schizophrenia: pooled analysis of data from three <scp>I</scp>ndian studies

Grover, Sandeep; Nebhinani, Naresh; Padmavati, Ramachandran; Chadda, Rakesh Kumar; Srinivasan, T. N.; Pallava, Abhishek

doi:10.1111/eip.12117

Cited by 11 publications

(6 citation statements)

References 35 publications

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“…This is much higher than a national NCDs survey that reported 4.8% prevalence 95 and comparable to a 16% pooled prevalence among HIV patients although the certainty of evidence was very low. 115 Higher prevalence were reported, despite the quality of the evidence was low, in people with psychiatric disorders (19%) 116 and arthritis (30.5%). 117 The differences in the prevalence among the studies could be explained by the fact that we only considered healthy adult populations without any underlining health conditions in this study, which could have underestimated the magnitude of the burden in the community.…”

Section: Discussionmentioning

confidence: 99%

Metabolic risk factors for non-communicable diseases in Ethiopia: a systematic review and meta-analysis

et al. 2021

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ObjectivesNon-communicable diseases (NCDs) are causing a new and yetsignificant health challenge in low-income countries. In Ethiopia, although 39% of deaths are NCD related, the health system remains underprepared, highlighting the clear need for evidence on risk factor distributions to inform resource planning and the health response. Therefore, this review investigates prevalence distributions and sex and age variations of metabolic risk factors among Ethiopian adults.Research design and methodsThis systematic review used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies published until 6 January 2021 were searched from PubMed, Scopus, ProQuest and Web of Science databases, reference lists of selected studies and grey literature. Studies reporting prevalence of metabolic risk factors: overweight/obesity, hypertension, impaired glucose homoeostasis and metabolic syndrome among Ethiopian adults were eligible for this systematic review and meta-analysis. Two authors independently extracted data and used the Joanna Briggs Institute tool for quality appraisal. The random effects model was used to conduct meta-analysis using Stata V.16. Subgroup analyses examined prevalence differences by region, study year, sample size and settings.ResultsFrom 6087 records, 74 studies including 104 382 participants were included. Most showed high prevalence of metabolic risk factors. Meta-analysis revealed pooled prevalence of metabolic risk factors from 12% to 24% with the highest prevalence observed for overweight/obesity (23.9%, 95% CI 19.9% to 28.0%) and hypertension (21.1%, 95% CI 18.7% to 23.5%), followed by metabolic syndrome (14.7%, 95% CI 9.8% to 19.6%) and impaired glucose tolerance (12.4%, 95% CI 8.7% to 16.1%). The prevalence of overweight/obesity was higher in women. All metabolic risk factors were higher among people aged above 45 years.ConclusionsA signficant proportion of Ethiopian adults have at least one metabolic risk factor for NCDs. Despite heterogeneity of studies limiting the certainty of evidence, the result suggests the need for coordinated effort among policymakers, healthcare providers, non-governmental stakeholders and the community to implement appropriate preventive measures to reduce these factors.

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Section: Discussionmentioning

confidence: 99%

Metabolic risk factors for non-communicable diseases in Ethiopia: a systematic review and meta-analysis

et al. 2021

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“…Several organizations have established criteria for the identification of MetS such as the National Cholesterol Education Program/Adult Treatment Panel III (ATP III) or International Diabetes Federation (IDF) [ 1 ]. Chronic mental disorders like schizophrenia and bipolar disorder have been associated with higher prevalence of MetS [ 2 , 3 ], which is contributing to the increased rates of mortality and morbidity in these patients [ 2 ]. Antipsychotics are also known to cause weight gain and increase in glucose or cholesterol levels [ 4 – 6 ], which also increase the prevalence of MetS.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of metabolic syndrome in patients receiving antipsychotics in Qatar: a cross sectional comparative study

et al. 2018

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BackgroundMetabolic abnormalities are common in patients maintained on antipsychotics. These abnormalities increase the risk of cardiovascular diseases and mortality in this population. The aim of this study is to assess the prevalence of metabolic syndrome (MetS) in subjects maintained on antipsychotics relative to controls in Qatar, and to assess the factors contributing to the development of MetS.MethodsA cross sectional design was used to collect data and fasting blood samples from subjects maintained on antipsychotics for at least six months (n = 112) and from a control group (n = 114). The groups were compared in regard to prevalence of MetS, and multiple regression analysis was used to determine the risk factors in each group.ResultsThe two groups (antipsychotics vs. control) were similar in regard to age (35.73 ± 10.28 vs. 35.73 ± 8.16 years) and gender ratio. The MetS was higher among the subjects on antipsychotics, but this difference did not reach statistical significance. Blood pressure (BP) was significantly higher in the antipsychotics group and BMI was the major risk factor to develop MetS in this group.ConclusionsThe prevalence of MetS in both groups is high and mostly attributed to obesity and high BP. Public health interventions are needed to address this major health problem overall. Larger studies are needed to further assess the impact of antipsychotics and mental illness on the development of MetS.

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“…In a meta-analysis of 18 studies, 60 per cent of excess mortality in schizophrenia was attributable to physical illness, with cardiovascular disease being the major cause 5 . Prevalence of MetS in patients with schizophrenia varies between 8.9 and 68 per cent, and is significantly higher in patients with schizophrenia compared to the healthy control group 7 . Metabolic syndrome, as a whole or its individual components, is seen to contribute to the physical morbidity of persons with serious mental illnesses.…”

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confidence: 91%

Metabolic syndrome, serious mental illnesses & lifestyle

Padmavati¹

2016

Indian Journal of Medical Research

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Metabolic syndrome in antipsychotic naïve patients with schizophrenia: pooled analysis of data from three Indian studies

Cited by 11 publications

References 35 publications

Metabolic risk factors for non-communicable diseases in Ethiopia: a systematic review and meta-analysis

Metabolic risk factors for non-communicable diseases in Ethiopia: a systematic review and meta-analysis

The prevalence of metabolic syndrome in patients receiving antipsychotics in Qatar: a cross sectional comparative study

Metabolic syndrome, serious mental illnesses & lifestyle

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