Metabolic syndrome in drug-naïve and drug-free patients with schizophrenia and in their siblings

Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis

“…Overall, we identified 31 eligible studies for inclusion in this meta‐analysis (Tables S3 and S4) (Arranz et al, ; Basoglu et al, ; Cai et al, ; Canan et al, ; Chang et al, ; Chen et al, ; Chen et al, ; Dasgupta, Singh, Rout, Saha, & Mandal, ; Enez Darcin, Yalcin Cavus, Dilbaz, Kaya, & Dogan, ; Fernandez‐Egea et al, ; Garcia‐Rizo et al, ; Garcia‐Rizo et al, ; Grover, Nebhinani, Chakrabarti, Avasthi, & Kulhara, ; Kavzoglu & Hariri, ; Keinanen et al, ; Leo et al, ; Misiak et al, ; Nyboe, Vestergaard, Moeller, Lund, & Videbech, ; Petrikis et al, ; Ryan et al, ; Saddichha, Manjunatha, Ameen, & Akhtar, ; Saloojee, Burns, & Motala, ; Sengupta et al, ; Spelman et al, ; Turan, Kesebir, & Suner, ; van Nimwegen et al, ; Venkatasubramanian et al, ; Wani et al, ; Wu et al, ; Yildirim et al, ; Zhang et al, ). Of these studies, one was conducted with patients who had a first episode mania (Turan et al, ), five were conducted with patients who had first episode depression (Canan et al, ; Chang et al, ; Garcia‐Rizo et al, ; Grover et al, ; Leo et al, ) and one was conducted with patients who had first episode mania or depression (Garcia‐Rizo et al, ).…”

Impaired Glucose Homeostasis in First-Episode Schizophrenia

“…Only 8 studies documented that participants were matched for ethnicity30,35,38,40–43,45, although our sensitivity analyses suggest that differences in ethnicities between groups were not responsible for the overarching findings of the meta-analysis. 1 study failed to match for gender32, and only 8 studies documented that participants were matched for smoking status30–32,35,37,38,43,45 (full details in Supplementary Information table 8). Other limitations of our study include between-sample heterogeneity in glucose homeostasis parameters tested, including the use of either the original HOMA equation20, or the HOMA2 equation21.…”

Cardiometabolic Risks in Schizophrenia and Directions for Intervention, 1:Magnitude and Moderators of the Problem

“…A case-control study 19 also reported increased prevalence of metabolic disturbances and MetS in 122 drug-naive or drug-free patients with schizophrenia.…”