Metabolic Syndrome in Female Patients With Overactive Bladder

Uzun, Hakkı; Zorba, Orhan Ünal

doi:10.1016/j.urology.2011.08.050

Cited by 78 publications

(90 citation statements)

References 28 publications

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“…The authors conclude that metabolic syndrome is highly correlated with OAB. 10 The results of the present study are consistent with those in the literature. The findings in the present study reinforce the correlation between obesity and overactive bladder that was found by the aforementioned authors.…”

Section: Resultssupporting

confidence: 93%

“…4 The high prevalence of OAB and its impact in quality of life justify the proposal of further related studies, so that new policies can be developed regarding information, treatment and improvement of quality of life in peo-ple affected by the condition. Strong associations between obesity and overactive bladder have been reported, [6][7][8][9][10] which led to the development of a deeper analysis regarding each individual symptom in our study.…”

Section: Introductionmentioning

confidence: 69%

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Correlation between body mass index and overactive bladder symptoms in pre-menopausal women

Palma¹,

Raimondi²,

Souto³

et al. 2014

Rev. Assoc. Med. Bras.

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Correlation between body mass index and overaCtive bladder symptoms in pre-menopausal women rev assoC med bras 2014; 60 (2) Conflict of interest: noneObjective: The aim of the study was to establish a correlation between Overactive Bladder (OAB) symptoms and Body Mass Index (BMI) in women aged 20-45. Methods: We interviewed 1.050 women aged 20-45 in the area of Campinas, Brazil, to investigate the prevalence of overactive bladder symptoms. In this study, we used the ICIQ-OAB questionnaire (ICS standard), in its validated portuguese version and a specific questionnaire for the demographics, which includes information about BMI. Results: Overall, women with BMI ≥30 presented a significantly higher score than women with a lower BMI (18.5 -24.9) (p=0.0066). In the analysis of individual symptoms, no significant differences were found regarding urinary frequency (p=0.5469). Women with BMI ≥30 presented more nocturia than women with BMI ranging between 18.5 and 24.9 (p=0.0154). Women in the group of BMI 25 -29.9 presented more urgency than women with BMI 18.5 -24.9 (p=0.0278). Significant difference was also found regarding urge-incontinence; women with BMI 25 -29.9 presented a higher score than women in the group 18.5 -24.9 (p= 0.0017). Analysis was also performed on the visual analogue scale regarding how much each symptom bothers the women (quality of life). There were no significant differences regarding frequency, nocturia or urgency but urgency incontinence bother was significant. Women with BMI 25 -29.9 were more bothered by incontinence than women with BMI 18.5 -24.9 (p=0.002). Conclusion:In conclusion, this study reinforces the correlation between BMI and OAB symptoms. Obese women present more OAB symptoms than non-obese women.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 69%

Correlation between body mass index and overactive bladder symptoms in pre-menopausal women

Palma¹,

Raimondi²,

Souto³

et al. 2014

Rev. Assoc. Med. Bras.

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“…Several studies have revealed a relationship between MetS and OAB [5,10,11] and their pathogeneses have many factors in common. For example, visceral obesity, aging, high body mass index, hypertension and increased HOMA-IR values have all been associated with both OAB and MetS [5,12]. Furthermore, MetS may contribute to sympathetic overactivity, causing detrusor overactivity and the activation of sensory neurons that secrete inflammatory mediators [13].…”

Section: Discussionmentioning

confidence: 99%

Association between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women with Overactive Bladder

Dağdeviren

Cengiz²

2017

Gynecol Obstet Invest

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Objective: This study aimed to determine the association between overactive bladder (OAB), metabolic syndrome (MetS) and serum nerve growth factors (NGF). Study Design: Serum samples from a group of 90 women that included patients with OAB (group 1), patients with both OAB and MetS (group 2) and healthy women without OAB and MetS (group 3). Each group included 30 patients. Serum levels of NGF were compared among the groups. Results: When the groups were compared with respect to NGF levels, group 2 was found to have significantly higher NGF levels (p = 0.001). A NGF threshold of >380 ng/mL had a sensitivity of 81.7% and a specificity of 100% to discriminate between groups 2 and 3. Conclusion: Our findings support the theory that possible sympathetic overactivity, proinflammatory status, oxidative stress and other pathological conditions associated with MetS and potentially involved in the development of OAB lead to increased serum NGF levels. These findings may help to shed light on the complicated pathogenesis of OAB.

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“…On the other hand, peripheral nerve damage in diabetic cerebral vasculopathy with decreased bladder capacity and presence of mimic OAB (22). Metabolic syndrome can be an etiologic pathway for the onset of OAB (23,24). Fayyad et al (25) documented bothersome LUTS in 40 % of the women patients with DM.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Overactive Bladder in Type 2 Diabetes Patients with a Questionaire-Based Study

Verim¹,

Kayataş²,

Abanonu³

et al. 2016

Haseki

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Abs tractAim: Overactive bladder (OAB) is a common and well-known urologic condition. OAB occurs in both women and men. Diabetes mellitus (DM) is one of the most common metabolic disorders in the world and the prevalence of DM in adults has been increasing. Diabetic neuropathy can induce functional disease of multiple organs, including diabetic bladder dysfunction (DBD). DBD occurs commonly as a late complication and DBD is mainly characterized by poor bladder emptying, urinary retention and overflow incontinence. However, storage symptoms, as those suggestive for OAB may also affect people with DM. The aim of this study was to evaluate the prevalence of OAB in people with DM compared to healthy control subjects. Methods: We analyzed records of 212 diabetic case and 229 control subjects using the 8-item symptom bother scale of the OAB questionnaire (OAB-q) (OAB-V8). Results:Diabetic bladder overactivity was seen in 20.3% of patients with DM (n=43) and 10.5% of non-diabetic control group (n=24). The OAB prevalence in patients with DM was approximately two-fold higher than in control subjects. OAB increased with the duration of diabetes, glycosylated hemoglobin level and age. There was no significant difference in sex distribution between the groups. There is an increase in the prevalence type 2 diabetes in Turkey. DM is a common cause of reduced bladder sensation in both men and women. In this study, OAB syndrome in diabetic patients was searched. DBD is characterized by underactive (flaccid) bladder, voiding difficulty, infrequent voiding and reduced bladder sensation during urinary storage; bladder underactivity and urinary retention during urination. OAB in diabetic patients is characterized by urgency (a compelling and sudden desire to void), with or without incontinence, usually with urinary frequency and nocturia. Conclusion: OAB symptoms are more prevalent in diabetic people than in healthy people. OAB symptoms in DM may be considered as a predictor of the development of diabetic neuropathy. Thus, controlling the progression of DM might reduce the incidence of diabetic neuropathy and other late diabetic complications.

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Metabolic Syndrome in Female Patients With Overactive Bladder

Cited by 78 publications

References 28 publications

Correlation between body mass index and overactive bladder symptoms in pre-menopausal women

Correlation between body mass index and overactive bladder symptoms in pre-menopausal women

Association between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women with Overactive Bladder

Evaluation of Overactive Bladder in Type 2 Diabetes Patients with a Questionaire-Based Study

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