Metabolic syndrome in menopause and associated factors: a meta-analysis

Pu, Danhua; Tan, Ruoyun; Yu, Qi; Wu, Jingjing

doi:10.1080/13697137.2017.1386649

Cited by 120 publications

(93 citation statements)

References 89 publications

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“…This continuously increasing prevalence in women could be a result of menopause. Menopause was reported to have an association with an increased risk of MeS and it is affecting all of its components [ 48 ]. On the contrary, the decrease in the prevalence among men and women after the sixth decade of life could be due to survival bias, where people affected by MeS die at a comparatively younger age, which leads to a depletion in the older age categories of affected individuals.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome amongst adults in Jordan: prevalence, trend, and its association with socio-demographic characteristics

Ajlouni

Khader

Alyousfi

et al. 2020

Diabetol Metab Syndr

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Background Multiple epidemiological studies were conducted amongst a variety of ethnic groups and showed discrepancies in the prevalence of metabolic syndrome (MeS) and its individual components. This study aimed to determine the prevalence of MeS in Jordan using both the Adult Treatment Panel Guidelines (ATP III) and the International Diabetes Federation (IDF) criteria. The study also aimed to assess the changes in the prevalence of MeS over time and determine its association with sociodemographic variables. Methods Data from the 2017 Cardiovascular Disease Risk Factors Survey were used for this study. Socio-demographic and clinical data were collected using a structured questionnaire. Blood samples were taken for biochemical measurements. Furthermore, anthropometric characteristics were measured by the same team of trained field researchers. A sample of 4,056 individuals aged between 18 and 90 years was included in this study. The findings from the 2017 survey were compared with the findings of a 2009 survey that adopted the same methods and procedures. Results According to the IDF criteria, the crude prevalence of Metabolic syndrome was 48.2% (52.9% among men and 46.2% among women; p < 0.001). Using the ATP III criteria, the prevalence was 44.1% (51.4% among men and 41% among women, p < 0.001). The age-standardized prevalence rate of metabolic syndrome was 44% (95% CI 42.7, 45.4) and 39.9% (95% CI 39.6, 41.2), according to both the IDF definition and ATP III criteria, respectively. The Kappa measure of agreement showed excellent agreement between the two definitions (k = 81.9%, p < 0.001). Of all participants, 41.7% met both the IDF and ATP III diagnostic criteria, 6.6% met the IDF criteria only, and 2.5% met the ATP III criteria only. The age-standardized prevalence rate of metabolic syndrome was significantly higher in 2017 (45.7% in men and 44.5% in women) than that in 2009 survey (34.6% in men and 39.8% in women). Gender, age, occupation, region, and marital status were significantly associated with metabolic syndrome. Conclusions The prevalence of metabolic syndrome in Jordan is considerably high and it is increasing. Healthy lifestyle programs encouraging appropriate dietary habits and physical activity are strongly recommended in Jordan.

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Section: Discussionmentioning

confidence: 99%

Metabolic syndrome amongst adults in Jordan: prevalence, trend, and its association with socio-demographic characteristics

Ajlouni

Khader

Alyousfi

et al. 2020

Diabetol Metab Syndr

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“…The complete atrophy of ovarian function and severe estrogen deficiency , which are risk factors for cardiovascular diseases and diabetes , have caused many postmenopausal women to suffer from sequelae of menopause syndrome, including breast cancer and other gynecological cancers. It has been demonstrated that modifying individual estrogen metabolism profiles can prevent breast cancer in postmenopausal women .…”

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confidence: 99%

Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

Zhao

Chen

et al. 2019

FEBS Letters

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Endogenous estrogen deficiency accelerates many diseases in postmenopausal women, and gut microbes contribute to estrogen level modulation. However, the compositional alterations and influences of the gut microbiota in postmenopausal women remain uncertain. A metagenome‐wide association study was performed to compare the gut microbiota of 24 premenopausal and 24 postmenopausal women. Firmicutes and Roseburia spp. are depleted, while Bacteroidetes and the toluene‐producing genus Tolumonas are overrepresented in fecal samples from postmenopausal women. The pentose phosphate pathway is enriched in premenopausal women. Homocysteine synthesis‐related processes are enriched in postmenopausal women. The gut microbiomes of premenopausal and postmenopausal women differ and produce different metabolites. The gut microbiome may be a therapeutic target to reduce risks and improve the quality of life in postmenopausal women.

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“…According to the results and for a better analysis of the obtained data, the subjects were divided in two groups, one with 25 (Fig. 6).…”

Section: Pth Vitamin D and Calciummentioning

confidence: 99%

Evaluation of Hemorheological Parameters as Biomarkers of Calcium Metabolism and Insulin Resistance in Postmenopausal Women

Farber

Dias

Freitas

et al. 2020

Preprint

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BACKGROUNDCalcium, vitamin D and insulin resistance are linked to osteoporosis and cardiovascular disease in menopause.OBJECTIVEDetermine if hemorheological parameters related to blood viscosity in microcirculation are linked to calcium metabolism and insulin resistance in menopause.METHODS25-Hydroxyvitamin D (25(OH)D)), 1,25-dihydroxyvitamin D3 (1,25(OH)2D), Parathyroid Hormone, ionized calcium, Glucose, Insulin and Hemoglobin A1c were measured in blood from 43 volunteers. Red blood cells (RBC) aggregation, RBC deformability and Whole Blood Viscosity were also performed.RESULTS25(OH)D showed a positive correlation with RBC deformability 0.60 Pa. Subjects with 25(OH)D ≤ 29.00 ng/mL had lower RBC deformability 0.60 Pa. and higher RBC Aggregation and higher HOMA-IR. Ionized calcium showed a negative correlation with RBC Aggregation. Subjects with ionized calcium ≤1.24 mmol/L showed higher RBC Aggregation. There was a positive correlation between HOMA-IR and RBC Aggregation and HOMA-IR showed a negative correlation with RBC deformability 0.30 Pa. Subjects with HOMA-IR<1.80 showed lower RBC aggregation and higher RBC deformability at 0.30 Pa, 0.60 Pa, 1.20 Pa, 3.0 Pa and 6.0 Pa.CONCLUSIONLow 25(OH)D, low ionized calcium and high HOMA-IR are related to impaired hemorheology in menopause. RBC aggregation and deformability can be used as biomarkers of calcium metabolism and insulin resistance in menopause.

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Metabolic syndrome in menopause and associated factors: a meta-analysis

Cited by 120 publications

References 89 publications

Metabolic syndrome amongst adults in Jordan: prevalence, trend, and its association with socio-demographic characteristics

Metabolic syndrome amongst adults in Jordan: prevalence, trend, and its association with socio-demographic characteristics

Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

Evaluation of Hemorheological Parameters as Biomarkers of Calcium Metabolism and Insulin Resistance in Postmenopausal Women

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