Metabolic syndrome in Thai schizophrenic patients: a naturalistic one-year follow-up study

Abstract

Background: Not only the prevalence, but also the progress of metabolic abnormalities in schizophrenic patients is of importance for treatment planning and policy making. However, there have been very few prospective studies of metabolic disturbance in schizophrenic patients. This study aimed to assess the progress of metabolic abnormalities in Thai individuals with schizophrenia by estimating their one-year incidence rate of metabolic syndrome (MetS).

The correlation between incidence of metabolic syndrome and sociodemographic and clinical characteristics in schizophrenia patients

“…While two studies suggested that diabetes and obesity are more common (24,31), results of several studies argued against it (19,24,27,29,32,36). Hägg and colleagues (33), found higher prevalence of CVDs among families of patients with MetS, however, this was not replicated in two other studies (27,36).…”

“…There were no differences between schizophrenia patients with or without MetS in terms of family history of schizophrenic disorders (27), HT (19,24,27,29,32), dyslipidemia (19) and cerebrovascular disorders (29). While two studies suggested that diabetes and obesity are more common (24,31), results of several studies argued against it (19,24,27,29,32,36).…”

“…Several studies did not find gender differences between schizophrenia patients with or without MetS (1,14,16,19,27,28,32,33). However, there are other studies which reported increased MetS prevalence in women (17,24,25,(28)(29)(30)35) or men (26).…”

“…While several studies found MetS to be more common in older patients (1,17,23,27,(29)(30)(31)35), fewer studies reported no age differences (26,32,36). There have been conflicting results regarding age of onset of the disorder ( 1 9 , 2 6 , 2 7 ) , d u r a t i o n o f t h e d i s o r d e r (1,24,26,27,29,31,32,34), education (28,31,32) and number of hospitalizations (15,19,32). Other studies reported higher body mass index (BMI) in schizophrenia patients with MetS (30,33,35).…”

The prevalence and mechanisms of metabolic syndrome in schizophrenia: a review

“…Incidence of metabolic syndrome A minority of studies calculated incidence rates of MetS [Attux et al 2007;L'Italien et al 2007;Saddichha et al 2007;Srisurapanont et al 2007;De Hert et al 2008b;Meyer et al 2008;Kim et al 2010;Kraemer et al 2010]. The results were hardly comparable in this field as incidence rates were calculated for various time periods, from 6 weeks up to 1 year.…”