Metabolic syndrome is a predictor of decreased renal function among community-dwelling middle-aged and elderly Japanese

Kawamoto, Ryuichi; Akase, Tomoko; Ninomiya, Daisuke; Kumagi, Teru; Kikuchi, Asuka

doi:10.1007/s11255-019-02320-0

Cited by 24 publications

(29 citation statements)

References 38 publications

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“…Strict glycemic control should be implemented in the patients of hyperglycemia. A cohort study performed by Kawamoto et al shows homogenous results 41 .…”

Section: Discussionmentioning

confidence: 97%

The prevalence and associated factors of metabolic syndrome in Chinese aging population

Ge¹,

Yang²,

Li³

et al. 2020

Sci Rep

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Metabolic syndrome (MetS) is hitting high notes in the aging society in China. However, the prevalence and associated factors in Chinese aging population lack clarity to some extent. In the present study, we projected to inquire into the prevalence of MetS and its associated factors by analyzing datasets downloaded from the China Health and Retirement Longitudinal Study (CHARLS). Data comprising age, gender, socioeconomic status, lifestyle and health behaviors as well as blood biomarkers were subjected to descriptive statistics followed by univariate logistic regression and multivariate logistic regression. The overall prevalence of MetS was 33.38% (95% CI 32.42–34.34%). With age augments, prevalence increased during 40–70 years, while declined in participants aged 70 years above. Females had 2.94 times of risks (95% CI 2.55–3.39, P < 0.001). Marital status and alcohol consumption contributed nothing to the suffering of MetS. Participants with GDP per capita > 10,000 RMB and a non-agricultural hukou sustained higher risks than other participants (P < 0.05). Participants under education of middle school suffered 1.16 times of risks than other level of education (95% CI 1.01–1.34, P < 0.05). Smokers, participants with high low-density lipoprotein (LDL) or hyperuricemia or high glycosylated hemoglobin HbA1c sustained increased risks (P < 0.05). In Chinese aging population, with the augment of age, the prevalence ascended in men, while descended in women and was interfered by socioeconomic status, lifestyle and health behaviors as well as blood biomarkers, but not marital status and alcohol consumption.

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“…Strict glycemic control should be implemented in the patients of hyperglycemia. A cohort study performed by Kawamoto et al shows homogenous results 41 .…”

Section: Discussionmentioning

confidence: 97%

The prevalence and associated factors of metabolic syndrome in Chinese aging population

Ge¹,

Yang²,

Li³

et al. 2020

Sci Rep

View full text Add to dashboard Cite

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“…Its multisystemic pattern is due to a pro‐inflammatory state, oxidative stress, haemodynamic dysfunction, and ischaemia, which overlap in ‘dysmetabolic’ patients. This results in multiple clinical entities, such as cardiovascular diseases (CVD), 9 non‐alcoholic steatohepatitis 10,11 and other liver dysfunctions, 12,13 chronic kidney disease, 14,15 many cancer types, 16 and neurodegenerative disorders (Figure 1). 17,18 …”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors

Rossi

Barbalho

Araújo

et al. 2021

Diabetes Metabolism Res

280

134

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Metabolic syndrome (MS) is a chronic non‐infective syndrome characterised clinically by a set of vascular risk factors that include insulin resistance, hypertension, abdominal obesity, impaired glucose metabolism, and dyslipidaemia. These risk factors are due to a pro‐inflammatory state, oxidative stress, haemodynamic dysfunction, and ischaemia, which overlap in ‘dysmetabolic’ patients. This review aimed to evaluate the relationship between the traditional components of MS with cardiovascular disease (CVD), inflammation, and oxidative stress. MEDLINE‐PubMed, EMBASE, and Cochrane databases were searched. Chronic low‐grade inflammatory states and metaflammation are often accompanied by metabolic changes directly related to CVD incidence, such as diabetes mellitus, hypertension, and obesity. Moreover, the metaflammation is characterised by an increase in the serum concentration of pro‐inflammatory cytokines, mainly interleukin‐1 β (IL‐1β), IL‐6, and tumour necrosis factor‐α (TNF‐α), originating from the chronically inflamed adipose tissue and associated with oxidative stress. The increase of reactive oxygen species overloads the antioxidant systems causing post‐translational alterations of proteins, lipids, and DNA leading to oxidative stress. Hyperglycaemia contributes to the increase in oxidative stress and the production of advanced glycosylation end products (AGEs) which are related to cellular and molecular dysfunction. Oxidative stress and inflammation are associated with cellular senescence and CVD. CVD should not be seen only as being triggered by classical MS risk factors. Atherosclerosis is a multifactorial pathological process with several triggering and aetiopathogenic mechanisms. Its medium and long‐term repercussions, however, invariably constitute a significant cause of morbidity and mortality. Implementing preventive and therapeutic measures against oxy‐reductive imbalances and metaflammation states has unquestionable potential for favourable clinical outcomes in cardiovascular medicine.

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“…Logistic regression analysis of MetS-related characteristics (quartile) in patients with and without kidney stones hemoglobin) levels were significantly associated with a decrease in eGFR within 3 years(16). A cohort study of Chinese centenarians showed that age, smoking, waist circumference, SBP, and TG levels were inversely associated with glomerular filtration rate, while DBP was positively associated with glomerular filtration rate(17).…”

mentioning

confidence: 97%

Incidence and correlation of metabolic syndrome and kidney stones in a healthy screening population

Qiu¹,

Ji³

et al. 2021

Transl Androl Urol

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Background: To study the incidence of metabolic syndrome (MetS) and kidney stones in a healthy screening population and to explore the correlation between them. Methods: The physical examination data of 11,827 people screened at the First Affiliated Hospital of Soochow University from August 2019 to July 2020 were analyzed. MetS diagnostic criteria were based on the 2004 guidelines of Chinese Diabetes Society (CDS). Multivariate logistic regression was used to analyze the correlation between MetS and various characteristics and kidney stones. Trend analysis was represented by P value, and P<0.05 indicated statistical significance. Results: The present study comprised 6,570 males (55.6%, aged 46.15±13.653 years) and 5,257 females (44.4%, aged 41.41±11.712 years). Of these, 1,036 (8.8%) had kidney stones and 1,552 (13.1%) had MetS. Among the MetS patients, 35.1% had a body mass index (BMI) ≥25, 27.7% had hypertension, 10.8% had hyperglycemia, and 31.2% had dyslipidemia. Kidney stone morbidity was 14.5% in the MetS group and 7.9% in the non-MetS group (P<0.05). As the number of MetS characteristics increased, kidney stone morbidity showed a linear increasing trend (P<0.05 for trend). With an increase in BMI and blood triglycerides (TG), and a decrease in lipoprotein cholesterol (HDL-C), the incidence of kidney stones had an increasing trend (P<0.05 for trend). Sex, age and MetS were independent risk factors for the occurrence of kidney stones, with and odds ratio (OR) of 1.493 [95% confidence interval (CI): 1.264-1.763] for MetS. Of the MetS characteristics, BMI ≥25 and blood pressure (BP) ≥140/90 mmHg were independent risk factors for kidney

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Metabolic syndrome is a predictor of decreased renal function among community-dwelling middle-aged and elderly Japanese

Cited by 24 publications

References 38 publications

The prevalence and associated factors of metabolic syndrome in Chinese aging population

The prevalence and associated factors of metabolic syndrome in Chinese aging population

Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors

Incidence and correlation of metabolic syndrome and kidney stones in a healthy screening population

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