Metabolic Syndrome Is Associated with Increased Arterial Stiffness and Biomarkers of Subclinical Atherosclerosis in Patients with Systemic Lupus Erythematosus

Sabio, José Mario; Vargas‐Hitos, José Antonio; Zamora-Pasadas, Mónica; Mediavilla, Juan Diego; Navarrete, Nuria Navarrete; Ramirez, A. Léndinez; Hidalgo-Tenorio, Carmen; Jáimez, L; Martín, Javier; Jiménez-Alonso, J

doi:10.3899/jrheum.081253

Cited by 81 publications

(60 citation statements)

References 43 publications

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“…The pulse pressure, pulse wave velocity and echocardiographic surrogate measurements of arterial stiffness increase with age and in certain disease states, indicating that they themselves are associated with increased cardiovascular risks, including that of hypertension, diabetes mellitus, hyperlipidemia, obesity and end-stage renal failure (17)(18)(19)(20). However, the state of arterial elasticity in subjects with prediabetes has also received little attention.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Aortic Stiffness and the Left Ventricular Function in Patients with Prediabetes

et al. 2014

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Objective Several studies have shown that arterial stiffness and ventricular dysfunction are increased in individuals with type 2 diabetes. Aortic stiffness (AS) reflects the mechanical tension and elasticity of the aorta, and increased aortic stiffness is a risk factor for cardiovascular disease. The aim of this study was to evaluate the degree of aortic stiffness and its relationship with the left ventricular (LV) function in patients with prediabetes and healthy control subjects. Methods The study groups were composed of 50 patients with prediabetes and 47 healthy adults with similar demographic characteristics. The LV systolic and diastolic functions were assessed using standard two dimensional (2D) echocardiography, M-mode echocardiography, pulsed-wave (PW) echocardiography and tissue Doppler echocardiography. The degree of aortic strain and distensibility were calculated based on the aortic diameters measured on M-mode echocardiography at a level 3 cm above the aortic valve and the blood pressure values obtained on sphygmomanometry. Results There were significant differences between the prediabetic and control groups in the degree of aortic strain (4.7±2.8% vs. 14.9±4.5%; respectively, p<0.001) and distensibility (2.0±1.5 vs. 6.8±2.3; 10 -3 cm 2 dyn -1 , respectively, p<0.001). In addition, significant differences were observed between the patient and control groups in the parameters of the LV systolic and diastolic functions. The left atrial diameter was significantly larger in the prediabetics than in the controls (35.9±3.9 vs. 33.7±4.2; respectively, p=0.027). Conclusion AS is increased in patients with prediabetes. In addition, there is a significant relationship between the degree of aortic stiffness and the LV function in this patient population. Therefore, the aortic elasticity parameters calculated on 2D echocardiography are useful for predicting early cardiovascular risks in prediabetics.

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Section: Discussionmentioning

confidence: 99%

Relationship between Aortic Stiffness and the Left Ventricular Function in Patients with Prediabetes

et al. 2014

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“…(10) Our findings of lack of association between MetS and other markers of inflammation (CRP and IL-6) in RA are in agreement with several studies (9, 10, 17), but differ from findings in patients with systemic lupus erythematosus (SLE) and in the general population. (18–21). Although the results of these studies are not consistent, an association between MetS and RA disease activity or severity seems likely and cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

Increased Prevalence of Metabolic Syndrome Associated with Rheumatoid Arthritis in Patients without Clinical Cardiovascular Disease

Crowson¹,

Myasoedova²,

Davis³

et al. 2010

J Rheumatol

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Objective The purpose of our study was to examine whether rheumatoid arthritis (RA) patients with no overt cardiovascular disease (CVD) have a higher prevalence of metabolic syndrome (MetS) than subjects without RA or CVD. We also examined whether RA disease characteristics are associated with the presence of MetS in RA patients without CVD. Methods Subjects from a population-based cohort of patients who fulfilled 1987 ACR criteria for RA between 1/1/1980 and 12/31/2007 were compared to non-RA subjects from the same population. All subjects with any history of CVD were excluded. Waist circumference, body mass index (BMI), and blood pressure were measured during the study visit. Data on CVD, lipids and glucose measures were ascertained from medical records. MetS was defined using NCEP/ATP III criteria. Differences between the 2 cohorts were examined using logistic regression models adjusted for age and sex. Results The study included 232 RA subjects without CVD and 1241 non-RA subjects without CVD. RA patients were significantly more likely to have an elevated waist circumference and elevated blood pressure than non-RA subjects, even though BMI was similar in both groups. Significantly more RA patients were classified as having MetS. In RA patients, MetS was associated with Health Assessment Questionnaire disability index, large joint swelling and uric acid levels, but not with C-reactive protein or RA therapies. Conclusion Among subjects without a history of CVD, RA patients are more likely to have MetS than non-RA subjects. MetS in RA patients was associated some measures of disease activity.

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“…SLE is associated with an increased prevalence of metabolic syndrome and patients have also been shown to have increased insulin resistance [90][91][92]. MetS has been shown to be associated with an increased CV risk profile in patients with SLE and may contribute directly to accelerated atherosclerosis [93,94].…”

Section: Metabolic Syndrome (Mets)mentioning

confidence: 98%

Why are kids with lupus at an increased risk of cardiovascular disease?

2015

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Juvenile-onset systemic lupus erythematosus (SLE) is an aggressive multisystem autoimmune disease. Despite improvements in outcomes for adult patients, children with SLE continue to have a lower life expectancy than adults with SLE, with more aggressive disease, a higher incidence of lupus nephritis and there is an emerging awareness of their increased risk of cardiovascular disease (CVD). In this review, we discuss the evidence for an increased risk of CVD in SLE, its pathogenesis, and the clinical approach to its management.

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Metabolic Syndrome Is Associated with Increased Arterial Stiffness and Biomarkers of Subclinical Atherosclerosis in Patients with Systemic Lupus Erythematosus

Abstract: MetS may contribute to the development of accelerated atherosclerosis in SLE.

Cited by 81 publications

References 43 publications

Relationship between Aortic Stiffness and the Left Ventricular Function in Patients with Prediabetes

Relationship between Aortic Stiffness and the Left Ventricular Function in Patients with Prediabetes

Increased Prevalence of Metabolic Syndrome Associated with Rheumatoid Arthritis in Patients without Clinical Cardiovascular Disease

Why are kids with lupus at an increased risk of cardiovascular disease?

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