Metabolic Syndrome Is Related to Nonalcoholic Steatohepatitis in Severely Obese Subjects

Huang, Hsien‐Liang; Lin, Wen Yuan; Lee, Long‐Teng; Wang, Hsih Hsi; Lee, Wei Jei; Huang, Kuo Chin

doi:10.1007/s11695-008-9423-0

Cited by 41 publications

(30 citation statements)

References 44 publications

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“…The hypertransaminasemia in NASH was found to be SGPT dominant in our study. Similar findings were reported by Sugimoto et al (2003) (17) . Singh et al,(2010)in their comparative study between NASH and ASH clearly showed SGPT levels were more elevated in NASH as compared to ASH(mean being110.82IU/L in NASH and 79.69IU/L in case of ASH).Also showed a higher AST/ALT ratio in ASH as compared to NASH(mean of 1.24+0.81 in ASH and 0.68+0.33 in NASH)This study strongly supports our finding that SGPT is a more relevant marker than SGOT in NASH patients and AST/ALT ratio Is >1 in ASH rather than NASH, which indeed helps in distinguishing between ASH and NASH.…”

Section: Discussionsupporting

confidence: 92%

Biochemical and Radiological Changes in Non Alcoholic Fatty Liver Diseases Compare with Obesity

Lamichaney¹

2017

jmscr

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Section: Discussionsupporting

confidence: 92%

Biochemical and Radiological Changes in Non Alcoholic Fatty Liver Diseases Compare with Obesity

Lamichaney¹

2017

jmscr

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“…Currently, NAFLD is the most prevalent liver disease in the United States, representing 20 to 30% of all liver disease cases (Bedogni et al, 2005). With obesity and obesity-related conditions (insulin resistance, dyslipidemia, and high blood pressure) identified as predisposing conditions, the occurrence of NAFLD is increasing as well (Huang et al, 2007;Targher et al, 2008). NAFLD composes a spectrum of etiologies ranging from simple fatty liver (steatosis) to the more severe nonalcoholic steatohepatitis (NASH).…”

mentioning

confidence: 99%

Hepatic Cytochrome P450 Enzyme Alterations in Humans with Progressive Stages of Nonalcoholic Fatty Liver Disease

Fisher

Lickteig

Augustine

et al. 2009

Drug Metabolism and Disposition

290

293

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ABSTRACT:Members of the cytochrome P450 (P450) enzyme families CYP1, CYP2, and CYP3 are responsible for the metabolism of approximately 75% of all clinically relevant drugs. With the increased prevalence of nonalcoholic fatty liver disease (NAFLD), it is likely that patients with this disease represent an emerging population at significant risk for alterations in these important drug-metabolizing enzymes. The purpose of this study was to determine whether three progressive stages of human NALFD alter hepatic P450 expression and activity. Microsomes isolated from human liver samples diagnosed as normal, n ‫؍‬ 20; steatosis, n ‫؍‬ 11; nonalcoholic steatohepatitis (NASH) (fatty liver), n ‫؍‬ 10; and NASH (no longer fatty), n ‫؍‬ 11 were analyzed for P450 mRNA, protein, and enzyme activity. Microsomal CYP1A2, CYP2D6, and CYP2E1 mRNA levels were decreased with NAFLD progression, whereas CYP2A6, CYP2B6, and CYP2C9 mRNA expression increased. Microsomal protein expression of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 tended to decrease with NAFLD progression. Likewise, functional activity assays revealed decreasing trends in CYP1A2 (p ‫؍‬ 0.001) and CYP2C19 (p ‫؍‬ 0.05) enzymatic activity with increasing NAFLD severity. In contrast, activity of CYP2A6 (p ‫؍‬ 0.001) and CYP2C9 (diclofenac, p ‫؍‬ 0.0001; tolbutamide, p ‫؍‬ 0.004) was significantly increased with NAFLD progression. Increased expression of proinflammatory cytokines tumor necrosis factor ␣ and interleukin 1␤ was observed and may be responsible for observed decreases in respective P450 activity. Furthermore, elevated CYP2C9 activity during NAFLD progression correlated with elevated hypoxia-induced factor 1␣ expression in the later stages of NAFLD. These results suggest that significant and novel changes occur in hepatic P450 activity during progressive stages of NAFLD.

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“…In this study, hypertension, hypercholesterolemia, hypertriglyceridemia, lower HDL, and higher fasting plasma glucose, the components of metabolic syndrome, are significantly related to NAFLD. Metabolic syndrome could be viewed as a strong predictor of NAFLD and NAFLD is also a good predictor for the clustering of components of risk factors for metabolic syndrome [25,26]. In addition, clinical manifestation of NAFLD is usually absent or subtle with abnormal aminotransferase or incidental radiographic findings of fatty liver [27].…”

Section: Discussion Prevalence and Cardiovascular Factors For The Devmentioning

confidence: 99%

Clinical epidemiology of prevalence and cardiovascular risk factors of nonalcoholic fatty liver disease among the elderly agricultural and fishing population in Taiwan

Sun¹,

Chen²,

Shen³

et al. 2017

Geriatr Med Care

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Purpose: To explore any gender-related differences in prevalence of and cardiovascular risk factors related to non-alcoholic fatty liver disease (NAFLD) amongst the elderly agricultural and fishing population in Taipei, Taiwan. Methods:The study participants were conducted with a total of 6,511 (3,971 males and 2,540 females) healthy elderly subjects voluntarily admitted to a teaching hospital for a physical check-up in 2010. Blood samples and real-time ultrasound-proved fatty liver sonography results were collected. Results:The prevalence of NAFLD for this elderly study population was found to be 27.2%, the proportion revealing a statistically significant decrease with increasing population age (p<0.001). Females showed a greater prevalence of NAFLD than did males (34.1% vs. 22.7%, p-value forχ 2 -test <0.001). Using multiple logistic regression analysis, in addition to female gender, a younger age, higher ALT, higher BMI, presence of hypercholesterolemia, hypertriglyceridemia, lower HDL, and higher fasting plasma glucose were the significant factors associated with NAFLD. Gender-related differences as regards associated factors were also revealed. For females, hypertension (OR=1.18, 95%CI: 1.00-1.40), and lower HDL (OR=1.31, 95%CI: 1.10-1.56) were significantly related to NAFLD but these were not so for males. Conclusion:Several gender-related differences were noted pertaining to the prevalence of and relationship between hypertension, lower HDL, and NAFLD in this occupational elderly study population.

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Metabolic Syndrome Is Related to Nonalcoholic Steatohepatitis in Severely Obese Subjects

Abstract: MetS and NASH were common in severely obese Taiwanese adults. Presence of MetS, high blood pressure, and high fasting glucose was independently related to increased risk of NASH. The underlying mechanism deserves to be explored in the future.

Cited by 41 publications

References 44 publications

Biochemical and Radiological Changes in Non Alcoholic Fatty Liver Diseases Compare with Obesity

Biochemical and Radiological Changes in Non Alcoholic Fatty Liver Diseases Compare with Obesity

Hepatic Cytochrome P450 Enzyme Alterations in Humans with Progressive Stages of Nonalcoholic Fatty Liver Disease

Clinical epidemiology of prevalence and cardiovascular risk factors of nonalcoholic fatty liver disease among the elderly agricultural and fishing population in Taiwan

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