Metabolic syndrome, lifestyle risk factors, and distal colon adenoma: A retrospective cohort study

Kim, Moon-Chan; Kim, Chang-Sup; Chung, Tae-Heum; Park, Hyoung-Ouk; Yoo, Cheol-In

doi:10.3748/wjg.v17.i35.4031

Cited by 19 publications

(17 citation statements)

References 30 publications

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“…We think that M2-PK levels in diabetic patients should be interpreted more cautiously. Many studies indicate that type -2 diabetic patients have an increased risk for developing cancer (15,16,18,(23)(24)(25). We could not find a relation between diabetes mellitus and histopathological diagnosis.…”

Section: Discussioncontrasting

confidence: 75%

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Diagnostic and prognostic value of tumor M2-pyruvate kinase levels in patients with colorectal cancer

Demir¹,

Erdenen²,

Muderrisoglu³

et al. 2009

Turk J Gastroenterol

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Section: Discussioncontrasting

confidence: 75%

“…The relationship between obesity and carcinogenesis is well known (16,(18)(19)(20). Number and size of adenomas were found to correlate with visceral fat accumulation (21).…”

Section: Discussionmentioning

confidence: 98%

Diagnostic and prognostic value of tumor M2-pyruvate kinase levels in patients with colorectal cancer

Demir¹,

Erdenen²,

Muderrisoglu³

et al. 2009

Turk J Gastroenterol

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“…This was in agreement with many other studies concluded that, higher tumor M2PK levels were found in patients with higher BMI. 22,23,24 But Haug et al 25 found no relationship between fecal M2PK levels and BMI so they addressed that obesity has no role in pathogenesis of cancer colon. The type of food consumed may affect the pathogenesis of cancer colon as high percentage of cancer colon patients 76% consumed low fiber and high protein diet and the mean level of M2PK in those patients was high (9.36±2.72), however no one in control group consumed such diet and their mean level of M2PK was normal (2.03±0.89) and this difference of food habit had a statistically significant importance (p value=0.001).…”

Section: Discussionmentioning

confidence: 99%

The Fecal M2-PK As A Novel Biomarker for Screening of Cancer Colon

2018

The Egypt. J. of Community Medicine

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Background: Cancer colon is one of most common cancers worldwide. Colonoscopy; an invasive and costly investigation method is the most reliable tool for diagnosis. Early diagnosis of cancer colon gives a high chance of cure. Fecal M2-PK; a tumor biomarker is a new approach for cancer colon screening. Objective: This study aimed to evaluate fecal M2-PK as a biomarker for cancer colon screening. Methods: This comparative crosssectional study included 3 groups: 30 healthy individuals (Group Ι), 50 diagnosed cancer colon patients (Group П) and 20 cancer colon patients who were the only operable patient from Group П (Group III). For all groups, history and physical examination was done. Fecal M2-PK concentrations were detected by ELISA. Results: The study revealed that there was a significant difference between cancer colon patients and healthy individuals (control) regarding age (p=0.046*), BMI (p=0.004*), history of smoking (p=0.025*), history of low fiber and high protein diet (p=0.001*), and levels of M2-PK (p=0.001*). There was a significant difference in the mean value of M2PK levels in relation to sex (p=0.043*) and site of cancer colon (p=0.002*) only. Cancer colon can be detected with fecal M2-PK with remarkable sensitivity &specificity (98% and 93% respectively). The overall accuracy of M2PK in detecting cancer colon was 96.6%. Conclusion: Fecal M2-PK is considered as a good screening biomarker for cancer colon.

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“…However, in contrast to CRC, studies that have suggested an association between clinical manifestations of MS and colorectal adenoma have shown considerable heterogeneity [12-17]. Moreover, there are only few studies examining the association between the individual components of MS and colorectal adenoma in Korea [18]. Thus, in the present study, we focused on the association between individual components of MS and colorectal adenoma in a Korean population.…”

Section: Introductionmentioning

confidence: 99%

Fasting Blood Sugar and Serum Triglyceride as the Risk Factors of Colorectal Adenoma in Korean Population Receiving Screening Colonoscopy

et al. 2013

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In several previously reported studies, metabolic syndrome (MS) was found to be associated with colorectal adenomas. While the incidence of colorectal adenoma is growing in Korean population, there are only few studies that examined the association between MS and colorectal adenoma in Korea. The aim of this study was to investigate relationships between prevalence of colorectal adenoma and MS components. We conducted a cross sectional study using data from individuals who had undergone complete colonoscopy for health examinations at the Health Promotion Center of Korea University Medical Center from July 1, 2004 to July 31, 2010. A total of 7481 subjects (4459 males and 3022 females) were included; 1733 subjects with pathologically proven adenoma were assigned to the case group, and other 5748 subjects were assigned to the non-case group. All the participants underwent colonoscopy and received blood biochemical tests (fasting blood sugar [FBS], insulin, lipid profile, hemoglobin, blood urea nitrogen [BUN], creatinine). Univariate analysis showed that the prevalence of colorectal adenoma was higher in individuals with higher blood pressure, body mass index (BMI), total cholesterol (TC), triglyceride (TG), FBS and lower high-density lipoprotein cholesterols (HDL-C) levels, compared to those with low levels. Multiple logistic regression analysis revealed that high levels of BMI (OR 1.17, 95% CI 1.01-1.34, P trend = 0.01), TG (OR 1.27, 95% CI 1.07-1.51, P trend = 0.006), and FBS (OR 1.19 95% CI 1.01-1.40, P trend = 0.05) were significantly associated with prevalence of colorectal adenoma. Subjects with high levels of BMI, TG and FBS have increased prevalence of developing colorectal adenoma in Korea.

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Metabolic syndrome, lifestyle risk factors, and distal colon adenoma: A retrospective cohort study

Abstract: Our results suggest that high BMI may increase the risk of colorectal adenoma in Korean adults.

Cited by 19 publications

References 30 publications

Diagnostic and prognostic value of tumor M2-pyruvate kinase levels in patients with colorectal cancer

Diagnostic and prognostic value of tumor M2-pyruvate kinase levels in patients with colorectal cancer

The Fecal M2-PK As A Novel Biomarker for Screening of Cancer Colon

Fasting Blood Sugar and Serum Triglyceride as the Risk Factors of Colorectal Adenoma in Korean Population Receiving Screening Colonoscopy

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