Metabolic syndrome markers and risk of hyperglycemia in pregnancy: a cross-sectional cohort study

Vernini, Joice Monaliza; Nicolosi, Bianca Fioravanti; Arantes, Mariana Alvarez; Costa, Roberto; Magalhães, Cláudia Garcia; Corrente, José Eduardo; Lima, Silvana Andréa Molina; Rudge, Marilza Vieira Cunha; Calderon, Iracema de Mattos Paranhos

doi:10.1038/s41598-020-78099-3

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Several other studies that evaluated individual metabolic parameters in early pregnancy, with pregnancy outcomes showing that early pregnancy hypertriglyceridemia is significantly associated with GDM [ 24 , 40 , 43 , 46 , 47 ] as well as hypertensive disorders in pregnancy [ 43 , 46 , 48 ]. Another recent study in Brazil showed high TG, WC, FPG, and BP act as independent risk factors for hyperglycaemia in pregnancy [ 49 ]. In this particular population, T2 GDM/DM incidence was not evident among those who already had T1 MetS.…”

Section: Discussionmentioning

confidence: 99%

Early pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka

Jayasinghe

Agampodi

Dissanayake

et al. 2023

BMC Pregnancy Childbirth

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Background Despite the intergenerational effects of metabolic disorders, evidence is greatly lacking on early pregnancy metabolic syndrome (MetS) and its effects on pregnancy outcomes from low- and middle-income countries. Thus, this prospective cohort of South Asian pregnant women aimed to evaluate how early pregnancy MetS would affect pregnancy outcomes. Methods A prospective cohort study was conducted among first-trimester (T1) pregnant women of Anuradhapura district, Sri Lanka recruited to the Rajarata Pregnancy Cohort in 2019. MetS was diagnosed by the Joint Interim Statement criteria before 13 weeks of gestational age (GA). Participants were followed up until their delivery, and the major outcomes measured were large for gestational age (LGA), small for gestational age (SGA), preterm birth (PTB) and miscarriage (MC). Gestational weight gain, gestational age at delivery and neonatal birth weight were used as measurements to define the outcomes. Additionally, outcome measures were re-assessed with adjusting fasting plasma glucose (FPG) thresholds of MetS to be compatible with hyperglycemia in pregnancy (Revised MetS). Results 2326 T1 pregnant women with a mean age of 28.1 years (SD-5.4), and a median GA of 8.0 weeks (IQR-2) were included. Baseline MetS prevalence was 5.9% (n = 137, 95%CI-5.0–6.9). Only 2027 (87.1%) women from baseline, had a live singleton birth, while 221(9.5%) had MC and 14(0.6%) had other pregnancy losses. Additionally, 64(2.8%) were lost to follow-up. A higher cumulative incidence of LGA, PTB, and MC was noted among the T1-MetS women. T1-MetS carried significant risk (RR-2.59, 95%CI-1.65–3.93) for LGA, but reduced the risk for SGA (RR-0.41, 95%CI-0.29–0.78). Revised MetS moderately increased the risk for PTB (RR-1.54, 95%CI-1.04–2.21). T1-MetS was not associated (p = 0.48) with MC. Lowered FPG thresholds were significantly associated with risk for all major pregnancy outcomes. After adjusting for sociodemographic and anthropometric confounders, revised MetS remained the only significant risk predictor for LGA. Conclusion Pregnant women with T1 MetS in this population are at an increased risk for LGA and PTB and a reduced risk for SGA. We observed that a revised MetS definition with lower threshold for FPG compatible with GDM would provide a better estimation of MetS in pregnancy in relation to predicting LGA.

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Section: Discussionmentioning

confidence: 99%

Early pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka

Jayasinghe

Agampodi

Dissanayake

et al. 2023

BMC Pregnancy Childbirth

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“…Another possibility is the potential impact of differences in the metabolic profiles of patients with and without GDM, and the incidence of metabolic syndrome (MetS) among them. MetS is a cluster of cardiovascular disease risk factors, including obesity, atherogenic dyslipidemia, raised blood pressure, insulin resistance, and pro-inflammatory states; although, there are several definitions and cut-points to describe and characterize MetS [ 49 , 50 ]. Women with MetS are at an increased risk of both PE and GDM [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Coexisting Gestational Diabetes Mellitus on the Course of Preeclampsia

Pankiewicz¹,

Szczerba²,

Fijałkowska³

et al. 2022

JCM

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A strict correlation between gestational diabetes mellitus (GDM) and preeclampsia (PE) has been shown in previous studies. This case-control observational study evaluates the influence of concomitant GDM on the severity of PE. Ninety-nine patients were included: thirty-eight with PE without GDM (group 1), fourteen with PE and concomitant GDM (group 2), and forty-seven with uncomplicated pregnancies (group 3). Adverse maternal/fetal and neonatal outcomes were registered. Patients underwent blood sample analysis of serum PlGF, sFlt-1, creatinine levels, and platelet count (PLT). The incidence of preterm birth, FGR, HELLP syndrome, and NICU admission was significantly higher in group 1 in comparison to groups 2 and 3, whereas RDS was diagnosed most often in group 2 in comparison to groups 1 and 3. All studied biochemical parameters differed between the control group and both PE groups; however, there were no differences between patients with PE with and without GDM. The presented study indicates that the coexistence of GDM may mitigate the course of PE. The lack of differences between patients with PE with and without GDM in serum levels of studied biomarkers may also confirm its usefulness in the diagnosis and management of PE in patients with coexisting GDM.

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Gestational diabetes mellitus according to different diagnostic criteria: Prevalence and related factors

Souza

Iser

2022

Midwifery

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Metabolic syndrome markers and risk of hyperglycemia in pregnancy: a cross-sectional cohort study

Cited by 4 publications

References 35 publications

Early pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka

Early pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka

The Impact of Coexisting Gestational Diabetes Mellitus on the Course of Preeclampsia

Gestational diabetes mellitus according to different diagnostic criteria: Prevalence and related factors

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