Metabolic syndrome, non-alcoholic fatty liver disease and hepatocarcinoma

Martín, Mario Serradilla; Guillén, José Ramón Oliver; Cano, Albert Julià; Ángel, José Manuel Ramia

doi:10.17235/reed.2020.6640/2019

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…Until now, a lot of substances secreted by adipose tissue have been discovered and described, and their metabolic effects and contribution to the pathogenesis of civilization-related diseases are being extensively studied [39][40][41][42]. It is interesting that both obese and lipodystrophic patients show similar clinical disorders: hypertriglyceridemia, insulin resistance and fatty liver [43][44][45]. The disorders lead to diabetes, hypertension, polycystic ovary syndrome (PCOS), coronary artery disease (CAD) and cancers [45][46][47][48][49][50].…”

Section: Adipokines and Metabolic Disordersmentioning

confidence: 99%

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Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications

Zorena

Jachimowicz-Duda²,

Ślęzak

et al. 2020

IJMS

275

196

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The World Health Organization (WHO) has recognized obesity as one of the top ten threats to human health. It is estimated that the number of obese and overweight people worldwide exceeds the number of those who are undernourished. Obesity is not only a state of abnormally increased adipose tissue in the body, but also of increased release of biologically active adipokines. Adipokines released into the circulating blood, due to their specific receptors on the surface of target cells, act as classic hormones affecting the metabolism of tissues and organs. What is more, adipokines and cytokines may decrease the insulin sensitivity of tissues and induce inflammation and development of chronic complications. Certainly, it can be stated that in an era of a global obesity pandemic, adipokines may gain more and more importance as regards their use in the diagnostic evaluation and treatment of diseases. An extensive search for materials on the role of white, brown and perivascular fatty tissue and obesity-related metabolic and chronic complications was conducted online using PubMed, the Cochrane database and Embase.

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Section: Adipokines and Metabolic Disordersmentioning

confidence: 99%

“…It is interesting that both obese and lipodystrophic patients show similar clinical disorders: hypertriglyceridemia, insulin resistance and fatty liver [43][44][45]. The disorders lead to diabetes, hypertension, polycystic ovary syndrome (PCOS), coronary artery disease (CAD) and cancers [45][46][47][48][49][50].…”

Section: Adipokines and Metabolic Disordersmentioning

confidence: 99%

Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications

Zorena

Jachimowicz-Duda²,

Ślęzak

et al. 2020

IJMS

275

196

View full text Add to dashboard Cite

show abstract

“…Central fat distribution also has an important effect on dyslipidemia. Abundant evidence shows that patients with obesity and lipodystrophy have similar clinical health conditions, namely hypertriglyceridemia, insulin resistance, and fatty liver [ 30 , 31 ]. It is estimated that the number of obese and overweight people worldwide exceeds the number of undernourished people [ 32 ].…”

Section: Obesity As a Risk Factor For Other Diseasesmentioning

confidence: 99%

Multidisciplinary Progress in Obesity Research

Lü

Jin

et al. 2022

Genes

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Obesity is a chronic disease that endangers human health. In recent years, the phenomenon of obesity has become more and more common, and it has become a global epidemic. Obesity is closely associated with many adverse metabolic changes and diseases, such as insulin resistance, type 2 diabetes mellitus, coronary heart disease, nervous system diseases and some malignant tumors, which have caused a huge burden on the country’s medical finance. In most countries of the world, the incidence of cancer caused by obesity is increasing year on year. Diabetes associated with obesity can lead to secondary neuropathy. How to treat obesity and its secondary diseases has become an urgent problem for patients, doctors and society. This article will summarize the multidisciplinary research on obesity and its complications.

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“…Approximately 30% of NAFLD patients suffer from metabolic abnormalities. 33,34 In many patients, both clinical conditions, NAFLD and MS, are early, almost simultaneous manifestations of IR. The current concept signals that NAFLD is the hepatic expression of MS, but frequently, hepatic abnormalities can worsen IR.…”

Section: R E L a T I O N S H I P B E T W E E N N A F L D Cardiovascu...mentioning

confidence: 99%

Dislipidemias, hígado graso y enfermedad cardiovascular

Carrillo‐Hidalgo¹,

Fonseca-Coronado²,

Ceballos³

et al. 2022

Cardiovasc Metab Sci

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NAFLD's clinical and economic burden will undoubtedly be overwhelming in the coming decades worldwide. 6 This article will address the association between NAFLD, metabolic syndrome, and cardiovascular disease.NAFLD, a silent pandemic. The global prevalence of NAFLD is 25.4%, being higher in South America (30.45%) and the Middle East (31.79%) and lower in Africa (13.48%). In Asia and the Pacific, NAFLD numbers are also increasing, mainly due to changes in diet and urbanization, and the adoption of the Western lifestyle. 1

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Metabolic syndrome, non-alcoholic fatty liver disease and hepatocarcinoma

Cited by 9 publications

References 23 publications

Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications

Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications

Multidisciplinary Progress in Obesity Research

Dislipidemias, hígado graso y enfermedad cardiovascular

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