Metabolic syndromes responsible for cervical cancer and advancement of nanocarriers for efficient targeted drug delivery- A review

Ashique, Sumel; Upadhyay, Aakash; Kumar, N. S. Sampath; Chauhan, Sanjana; Mishra, Neeraj

doi:10.1016/j.adcanc.2022.100041

Cited by 17 publications

(1 citation statement)

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“…Cell proliferation is one of the major steps in cancer cells metastasis of a multistep process that includes cell adhesion, invasion, transport through circulatory system and growth in a secondary organ 1 . Cervical cancer is the third incessant cancer type faced by women 2 . In recent years, many efforts on searching for efficient anticancer agents from natural products lead to increasing interest in polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of unique sustain modified chitosan nanoparticles for biomedical applications

Ahmed,

Mohamed,

Ahmed

et al. 2024

Sci Rep

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Chitosan (CS) is a biopolymer that offers a wide range in biomedical applications due to its biocompatibility, biodegradability, low toxicity and antimicrobial activity. Syringaldehyde (1) is a naturally occurring organic compound characterized by its use in multiple fields such as pharmaceuticals, food, cosmetics, textiles and biological applications. Herein, development of chitosan derivative with physicochemical and anticancer properties via Schiff base formation from the reaction of chitosan with sustainable eco-friendly syringaldehyde yielded the (CS-1) derivative. Moreover, in the presence of polyethylene glycol diglycidyl ether (PEGDGE) or sodium tripolyphosphate (TPP) as crosslinkers gave chitosan derivatives (CS-2) and (CS-3NPs) respectively. The chemical structures of the new chitosan derivatives were confirmed using different tools. (CS-3NPs) nanoparticle showed improvement in crystallinity, and (CS-2) derivative revealed the highest thermal stability compared to virgin chitosan. The cytotoxicity activity of chitosan and its derivatives were evaluated against HeLa (human cervical carcinoma) and HEp-2 (Human Larynx carcinoma) cell lines. The highest cytotoxicity activity was exhibited by (CS-3NPs) compared to virgin chitosan against HeLa cell growth inhibition and apoptosis of 90.38 ± 1.46% and 30.3% respectively and IC50 of 108.01 ± 3.94 µg/ml. From the above results, it can be concluded that chitosan nanoparticle (CS-3NPs) has good therapeutic value as a potential antitumor agent against the HeLa cancer cell line.

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Section: Introductionmentioning

confidence: 99%