2023
DOI: 10.1021/acschembio.3c00501
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Metabolic Usage and Glycan Destinations of GlcNAz in E. coli

Alexander Eddenden,
Manoj K. Dooda,
Zachary A. Morrison
et al.

Abstract: Bacteria use a diverse range of carbohydrates to generate a profusion of glycans, with amino sugars, such as Nacetylglucosamine (GlcNAc), being prevalent in the cell wall and in many exopolysaccharides. The primary substrate for GlcNAccontaining glycans, UDP-GlcNAc, is the product of the bacterial hexosamine pathway and a key target for bacterial metabolic glycan engineering. Using the strategy of expressing NahK, to circumvent the hexosamine pathway, it is possible to directly feed the analogue of GlcNAc, N-a… Show more

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