Metabolic Variability Analysis Using a Mixing Chamber-Breath by Breath based Indirect Calorimeter and the Clino-Ortho Maneuver

Abstract

This work proposes the clino-ortho maneuver to analyze the metabolic energy expenditure variability by Indirect Calorimetry (IC). This analysis uses a hybrid calorimeter which includes simultaneously the mixing-chamber (MC) and the breath by breath (BbB) IC techniques. VO2 and VCO2 short-term variability was characterized as metabolic variability in the MC technique by intra-group standard deviation averages. When the BbB technique was used the metabolic variability characterization was done by VO2 and VCO2 discrete time series power spectrum analysis in the 0-0.5 Hz band. Thus a statistical population of 17 young healthy volunteers was studied using a clino-ortho maneuver with 30-30 minutes in each position after 8 hours of fasting. The results showed an energy expenditure change of 40% in Kcal/day (p<0.01). The metabolic variability was partially significant using the MC technique while BbB total power spectrum changed from 35 to 60 for the VO2 and from 24 to 37 for the VCO2 (ml/bth)(2), (p<0.05) in the region from 0 to 0.04 Hz. It was concluded that using this new measurement technique and the clino-ortho maneuver metabolic variability information not yet studied was revealed.