Metabolically healthy obesity is associated with longitudinal changes in high-density lipoprotein cholesterol in Chinese adults

Yang, Yan; Yan, Wei; Fan, Zhu; Gao, Xiang; Jiang, An; Xu, Renying

doi:10.1007/s40519-020-00847-1

Cited by 2 publications

(4 citation statements)

References 35 publications

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Section: Discussionmentioning

confidence: 99%

“…Due to the unfavorable changes in diets, the prevalence of obesity and metabolic abnormalities has increased year-by-year in China, 34 and the prevalence of metabolic abnormalities-related kidney diseases has also increased gradually. Studies have shown that increasing age, 23 overnutrition, 24 sex differences in the number of lipid glucocorticoid receptors and estrogen secretion, 25 , 26 abnormal lipid levels, 28 , 29 and insulin resistance 20 , 27 are involved in the development of morbid obesity. We attempted to predict CKD risk using the anthropometric indicators BMI, WHtR, 35 , 36 visceral fat index, 37 and insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…20,27 Increased circulating levels of TGs, decreased clearance of LDL-C, and long-term maintenance of lower levels of HDL-C are involved in obesity development. 28,29 METS-VF integrates the above parameters stated above to assess the metabolic status of visceral fat, which can reflect the risk of human disease to a certain extent. 9 The gold standard for VAT evaluation is MRI, and the other detection methods are computed tomography, dual X-ray absorptiometry (DXA), and bioelectrical impedance analysis (BIA).…”

Section: Discussionmentioning

confidence: 99%

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Metabolism Score for Visceral Fat (METS-VF): A New Predictive Surrogate for CKD Risk

Feng¹,

Chen²,

Wang³

et al. 2022

DMSO

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Purpose Metabolic disorders are closely related to the occurrence and development of chronic kidney disease (CKD). We explored the prospective association between the Metabolic Score for Visceral Fat (METS-VF) and CKD in a 5-year follow-up study. Patients and Methods In this cohort study, 631 adults not suffering from CKD from Wanzhai Town, in China in 2012 were included at baseline and followed up in 2017 and 2018. Multivariable logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between METS-VF and CKD risk. Area under the receiver operating characteristic curve (AUC) analyses were used to evaluate the ability of METS-VF, waist-to-height ratio (WhtR), visceral adiposity index (VAI), homeostatic model assessment of insulin resistance (HOMA-IR), body mass index (BMI) to predict CKD risk. Results We identified 103 CKD cases during follow-up. After adjustment for confounding factors, comparing the lowest quartile of METS-VF, the OR (95% CI) of CKD risk in the highest quartile was 3.04 (1.39–6.64). The per Standard deviation (SD) increase in METS-VF was positively correlated with CKD risk. The AUC of METS-VF for predicting CKD risk was, in general, higher than that for WhtR, VAI, HOMA-IR, and BMI. Conclusion METS-VF may be an indicator for predicting CKD risk.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Metabolism Score for Visceral Fat (METS-VF): A New Predictive Surrogate for CKD Risk

Feng¹,

Chen²,

Wang³

et al. 2022

DMSO

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“…Cholestasis was also determined if TBIL (≥34.2 μ mol/L) or DBIL (≥13.6 μ mol/L) was greater than twofold of upper limit [ 25 ]. Dyslipidemia was diagnosed if TC ≥ 5.72 mmol/L or TG ≥ 1.7 mmol/L [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

The Association between Serum Level of Vitamin D and Inflammatory Biomarkers in Hospitalized Adult Patients: A Cross-Sectional Study Based on Real-World Data

Zhang,

Chen,

Xiang

et al. 2024

Mediators of Inflammation

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Objective. The association between vitamin D status and inflammation remains unclear in hospitalized patients. Materials and Methods. We performed the current study based on real-world data from two teaching hospitals. Serum level of vitamin D (assessed by 25-hydroxyvitamin D) was evaluated within 2 days after admission. All the patients were further classified into three groups: deficiency (<12 ng/mL), insufficiency (12–20 ng/mL), and adequate (≥20 ng/mL). White blood cell (WBC) count, serum level of C-reactive protein (CRP), and procalcitonin were also measured and used to evaluate inflammation. Other potential covariates were abstracted from medical records. Charlson comorbidity index (CCI) was calculated to assess the severity of disease. Results. A total number of 35,528 hospitalized adult patients (21,171 men and 14,357 women) were included. The average age and BMI were 57.5 ± 16.2 years and 23.4 ± 3.7 kg/m2, respectively, while medium vitamin D level was 16.1 ng/mL (interquartile range: 11.4 ng/mL, 21.6 ng/mL) and median CCI was one point (interquartile range: 0 point, two points). The prevalence of deficiency and insufficiency was 28.0% and 40.5%. Multivariate linear regression model showed that serum level of vitamin D was significantly associated with WBC and CRP but not associated with procalcitonin. Each standard deviation (≈7.4 ng/mL) increase in vitamin D was associated with a decrease in WBC by 0.13 × 109/mL (95% CI: 0.2 × 109/mL, 0.06 × 109/mL) and 0.62 mg/L (95% CI: 0.88 mg/L, 0.37 mg/L) for CRP. Subgroup analysis and sensitivity analysis (excluding those whose eGFR <60 ml/min/1.73 m2, those whose daily calorie intake <1,000 kcal, and those who were recruited from Xin Hua hospital) generated similar results. Conclusions. The deficiency and insufficiency of vitamin D in the hospitalized adult patients was very common. However, the results should be interpreted with caution for limited representation of the whole inpatients. Low level of vitamin D was associated with inflammatory biomarkers, which provide the evidences to early intervention for lower the risk of infection.

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Metabolically healthy obesity is associated with longitudinal changes in high-density lipoprotein cholesterol in Chinese adults

Cited by 2 publications

References 35 publications

Metabolism Score for Visceral Fat (METS-VF): A New Predictive Surrogate for CKD Risk

Metabolism Score for Visceral Fat (METS-VF): A New Predictive Surrogate for CKD Risk

The Association between Serum Level of Vitamin D and Inflammatory Biomarkers in Hospitalized Adult Patients: A Cross-Sectional Study Based on Real-World Data

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