Metabolism and Calcium Antagonism of Sodium Alginate Oligosaccharides

Chaki, Takamitsu; Kajimoto, Noriyoshi; Ogawa, Hiroshi; Baba, Takashi; Hiura, Nozomi

doi:10.1271/bbb.60620

Cited by 24 publications

(10 citation statements)

References 15 publications

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“…Farmer et al have proposed that uronide-Ca 2+ complexes might be the active molecular species that initiate the signal transduction pathways leading to enhance growth and proliferation (40). Chaki et al have suggested that sodium alginate oligosaccharides exerted antagonist activity towards calcium channels, especially voltage-operated calcium channels (41).…”

Section: Resultsmentioning

confidence: 99%

Effects of sulfated fucan, ascophyllan, from the brown Alga Ascophyllum nodosum on various cell lines: A comparative study on ascophyllan and fucoidan

Jiang

Okimura²,

Yokose

et al. 2010

Journal of Bioscience and Bioengineering

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Abstract:The effects of fucose-containing sulfated polysaccharides, ascophyllan and fucoidan, isolated from the brown alga Ascophyllum nodosum, on the growth of various cell lines (MDCK, Vero, PtK 1 , CHO, HeLa, and XC) were investigated. In a colony formation assay, ascophyllan and fucoidan showed potent cytotoxic effects on Vero and XC cells, while other cell lines were relatively resistant to these polysaccharides. Almost no significant effects of these polysaccharides were observed in the cell lines tested using the Alamar blue cytotoxicity assay over 48 h with varying initial cell densities (2500-20,000 cells/well) in growth medium. Interestingly, a significant growth promoting effect of ascophyllan on MDCK cells was observed, whereas treatment with fucoidan showed growth suppressive effects on this cell line under the same experimental conditions. These results suggest that ascophyllan is distinguishable from fucoidan in terms of their bioactivities. This is the first report of the growth promoting effects of a sulfated fucan on a mammalian cell line under normal growth conditions. 4

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Section: Resultsmentioning

confidence: 99%

Effects of sulfated fucan, ascophyllan, from the brown Alga Ascophyllum nodosum on various cell lines: A comparative study on ascophyllan and fucoidan

Jiang

Okimura²,

Yokose

et al. 2010

Journal of Bioscience and Bioengineering

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“…Chaki et al have reported that small amounts of AOs were detected in blood plasma after oral administration of AOs to 8-week-old male Wister rats (n ¼ 2). 16) This finding suggests the possibility of gastrointestinal absorption of orally administrated AOs, but there is no further information regarding pharmacokinetic analysis of orally administered AOs in experimental animal models. In our preliminary experiments, it was found that a LC-MS/MS method can quantitatively detect even small amounts of AOs, and that the method is applicable in in vivo pharmacokinetic analysis of AOs.…”

mentioning

confidence: 99%

Detection and Pharmacokinetics of Alginate Oligosaccharides in Mouse Plasma and Urine after Oral Administration by a Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Method

Nishikawa

Yokose

Yamamoto

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…Seaweed contains large quantities of minerals and alginate, which is a kind of dietary fiber. Alginate has been reported to reduce blood pressure [36], and Yamori et al presumed that alginic acid in seaweed may cause the inhibition of intentional sodium absorption [23]. Potassium, calcium and magnesium also have been reported to reduce blood pressure in observational studies [13,16,17] and intervention trials [9-11,18].…”

Section: Discussionmentioning

confidence: 99%

Seaweed intake and blood pressure levels in healthy pre-school Japanese children

Wada

Nakamura

Tamai

et al. 2011

Nutr J

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BackgroundFew studies have examined whether dietary factors might affect blood pressure in children. We purposed to investigate whether seaweed intake is associated with blood pressure level among Japanese preschool children.MethodsThe design of the study was cross-sectional and it was conducted in autumn 2006. Subjects were healthy preschoolers aged 3-6 years in Aichi, Japan. Blood pressure and pulse were measured once by an automated sphygmomanometer, which uses oscillometric methods. Dietary data, including seaweed intake, were assessed using 3-day dietary records covering 2 consecutive weekdays and 1 weekend day. Of a total of 533 children, 459 (86.1 percent) agreed to be enrolled in our study. Finally, blood pressure measurement, complete dietary records and parent-reported height and weight were obtained for 223 boys and 194 girls.ResultsWhen we examined Spearman's correlation coefficients, seaweed intake was significantly negatively related to systolic blood pressure in girls (P = 0.008). In the one-way analysis of covariance for blood pressure and pulse after adjustments for age and BMI, the boys with the lowest, middle and highest tertiles of seaweed intake had diastolic blood pressure readings of 62.8, 59.3 and 59.6 mmHg, respectively (P = 0.11, trend P = 0.038). Girls with higher seaweed intake had significantly lower systolic blood pressure readings (102.4, 99.2 and 96.9 mmHg for girls with the lowest, middle and highest tertiles of seaweed intake, respectively; P = 0.037, trend P = 0.030).ConclusionOur study showed that seaweed intake was negatively related to diastolic blood pressure in boys and to systolic blood pressure in girls. This suggests that seaweed might have beneficial effects on blood pressure among children.

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Metabolism and Calcium Antagonism of Sodium Alginate Oligosaccharides

Cited by 24 publications

References 15 publications

Effects of sulfated fucan, ascophyllan, from the brown Alga Ascophyllum nodosum on various cell lines: A comparative study on ascophyllan and fucoidan

Effects of sulfated fucan, ascophyllan, from the brown Alga Ascophyllum nodosum on various cell lines: A comparative study on ascophyllan and fucoidan

Detection and Pharmacokinetics of Alginate Oligosaccharides in Mouse Plasma and Urine after Oral Administration by a Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Method

Seaweed intake and blood pressure levels in healthy pre-school Japanese children

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