Metabolism and the heart: An overview of muscle, fat, and bone metabolism in heart failure

Loncar, Goran; Fülster, Susann; Haehling, Stephan von; Popović, Vera

doi:10.1016/j.ijcard.2011.09.079

Cited by 72 publications

(83 citation statements)

References 138 publications

(167 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Skeletal muscle wasting in HF is a complex process integrating failing heart, skeletal muscle, fat and bone tissue, and is likely to be caused by the above-mentioned core components of HF. 6,22,23) Several possible explanations could account for our finding that existing sarcopenia potentially aggravates ADHF. There is increasing evidence for crosstalk between the heart and adipose tissue, although precise mechanisms remain undefined.…”

Section: Discussionmentioning

confidence: 94%

Significance of Sarcopenia Evaluation in Acute Decompensated Heart Failure

et al. 2018

View full text Add to dashboard Cite

SummaryIn patients with chronic heart failure (HF), the clinical importance of sarcopenia has been recognized in relation to disease severity, reduced exercise capacity, and adverse clinical outcome. Nevertheless, its impact on acute decompensated heart failure (ADHF) is still poorly understood. Dual-energy X-ray absorptiometry (DXA) is a technique for quantitatively analyzing muscle mass and the degree of sarcopenia. Fat-free mass index (FFMI) is a noninvasive and easily applicable marker of muscle mass.This was a prospective observational cohort study comprising 38 consecutive patients hospitalized for ADHF. Sarcopenia, derived from DXA, was defined as a skeletal muscle mass index (SMI) two standard deviations below the mean for healthy young subjects. FFMI (kg/m 2 ) was calculated as 7.38 + 0.02908 × urinary creatinine (mg/day) divided by the square of height (m 2 ). Sarcopenia was present in 52.6% of study patients. B-type natriuretic peptide (BNP) levels were significantly higher in ADHF patients with sarcopenia than in those without sarcopenia (1666 versus 429 pg/mL, P < 0.0001). Receiver operator curves were used to compare the predictive accuracy of SMI and FFMI for higher BNP levels. Areas under the curve for SMI and FFMI were 0.743 and 0.717, respectively. Multiple logistic regression analysis showed sarcopenia as a predictor of higher BNP level (OR = 18.4; 95% CI, 1.86-181.27; P = 0.013).Sarcopenia is associated with increased disease severity in ADHF. SMI based on DXA is potentially superior to FFMI in terms of predicting the degree of severity, but FFMI is also associated with ADHF severity.(Int Heart J 2018; 59: 143-148)

show abstract

Section: Discussionmentioning

confidence: 94%

Significance of Sarcopenia Evaluation in Acute Decompensated Heart Failure

et al. 2018

View full text Add to dashboard Cite

show abstract

“…2). The metabolism and function of liver [53], kidneys [54], bones [55] as well as adipose tissues [55] and skeletal muscles [55][56] are impaired. Common feature observed in chronic HF patients is passive venous congestion of the liver usually combined with an organ enlargement.…”

Section: Heart Failure -A Multisystemic Diseasementioning

confidence: 99%

Metabolomics — A wide-open door to personalized treatment in chronic heart failure?

Marcinkiewicz-Siemion

Ciborowski

Krętowski

et al. 2016

International Journal of Cardiology

View full text Add to dashboard Cite

“…Recent studies suggest that the failing heart acts on fat metabolism via secretion of natriuretic peptides by inducing adiponectin secretion and lipolytic actions [18]. Soluble myostatin released from the failing heart may induce skeletal muscle wasting in HF through an endocrine-like mechanism as well [18].…”

Section: Metabolic Changes In the Myocardiummentioning

confidence: 99%

“…Soluble myostatin released from the failing heart may induce skeletal muscle wasting in HF through an endocrine-like mechanism as well [18].…”

Section: Metabolic Changes In the Myocardiummentioning

confidence: 99%

Muscle in heart disease: Highlights from the European Society of Cardiology's Annual Meeting 2012

Sandek

Haehling

Anker

2012

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

Metabolism and the heart: An overview of muscle, fat, and bone metabolism in heart failure

Cited by 72 publications

References 138 publications

Significance of Sarcopenia Evaluation in Acute Decompensated Heart Failure

Significance of Sarcopenia Evaluation in Acute Decompensated Heart Failure

Metabolomics — A wide-open door to personalized treatment in chronic heart failure?

Muscle in heart disease: Highlights from the European Society of Cardiology's Annual Meeting 2012

Contact Info

Product

Resources

About