Metabolism and Toxicity of Intravenously Injected Yttrium Chloride in Rats

Hirano, Seishiro; Kodama, Naoko; Shibata, Katsunari; Suzuki, Kenta

doi:10.1006/taap.1993.1149

Cited by 56 publications

(28 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has also been shown that EDTA-chelated Sc was rapidly taken up by the kidney with subsequent elimination via the urine, while ScCl3 was extensively deposited in the liver and spleen in mice (64). We have reported that iv-injected YCl3 was taken up by phagocytes of the liver and spleen in rats and the half-time of Y in the liver was 144 days (46). Taken together, chelated RE are excreted mainly via urine after transient accumulation in the kidney and their whole body half-times are several hours; RE chlorides are taken up by the liver and spleen, and those RE are not easily excreted.…”

Section: Exposure To Rare Earthsmentioning

confidence: 92%

“…The first three RE decreased RNA polymerase II activity while the latter three RE increased the activity; only Pr and Nd nitrates decreased RNA polymerase I activity while the other four did not change the RNA polymerase I activity. Otherwise, the biochemical changes are consistent among RE; those biochemical changes are increase in triglyceride in the liver (105,110,113,117) and increases in leakage of hepatic enzymes into blood (46,105,(111)(112)(113)(114)(115)(116). RE-induced hepatic injury seems to reduce P450 content and P450-related enzyme activities in rat (113) and mouse (109,119); however, the decreases in P450 activities (coumarin 7-hydroxylase and 7-ethoxyresorufin O-deethylase) at 3 to 4 days after iv injection of CeCI3 were preceded by increases in these enzyme activities at 1 to 2 days postinjection in DBA/2 mice (109,119).…”

Section: Exposure To Rare Earthsmentioning

confidence: 93%

“…Rossoff et al (68) (46). Uptake of Y by the liver and spleen also increased with the dose of YCl3 (46).…”

Section: Exposure To Rare Earthsmentioning

confidence: 96%

“…It has been reported that Sc3+, Y3+, and La3+ bind to globulin and DNA (44), and transferrin is a major Sc3+-or Y3+-binding protein in blood plasma (45,46 (17), respectively, when these RE were instilled intratracheally as chlorides. Rhoads and Sanders (51) have reported a half-time of intratracheally instilled Yb2O3 in the rat lung of 21 days.…”

Section: Exposure To Rare Earthsmentioning

confidence: 99%

See 3 more Smart Citations

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Hirano¹,

Suzuki²

1996

Environmental Health Perspectives

153

187

View full text Add to dashboard Cite

show abstract

Section: Exposure To Rare Earthsmentioning

confidence: 92%

Section: Exposure To Rare Earthsmentioning

confidence: 93%

“…Rossoff et al (68) (46). Uptake of Y by the liver and spleen also increased with the dose of YCl3 (46).…”

Section: Exposure To Rare Earthsmentioning

confidence: 96%

Section: Exposure To Rare Earthsmentioning

confidence: 99%

See 2 more Smart Citations

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Hirano¹,

Suzuki²

1996

Environmental Health Perspectives

153

187

View full text Add to dashboard Cite

show abstract

“…Although the yttrium has been used as treatment of some disease as rheumatoid arthritis, Hirano et al 20 showed acute toxicity of yttrium in rats intravenously injected with this metal. It appears in colloidal material composed by proteins and minerals phagocytes in the liver and spleen, when the doses are superior to 0.2 mg/rat.…”

Section: Resultsmentioning

confidence: 99%

Metallic ions in organs of rats injected with metallic particles of stainless steel 316L and Ti6Al4V alloy

Giertz

Fernandes

Fernandes³

et al. 2010

Mat. Res.

View full text Add to dashboard Cite

Despite the interest in identifying systemic effects caused by the metallic particles released from long term metallic implants in the body, few works support reliable conclusions about the effects of those particles in organs. The aim of the present work is to look for damages in tissues of liver, kidney, lung and heart of rats submitted to injection of Hank's solution contained particles of Ti6Al4V alloy and Stainless Steel 316L, obtained by metal friction. The particles size ranges from 50 to 200 µm for the Ti alloy and from 100 to 500 µm for the 316L. Tissues isolated from the organs after the euthanasia were prepared and analyzed in an optical microscope and Energy Dispersive Spectrometer (EDS). Lesions caused by an inflammatory response such as strange body epithelioid granuloma and giant cells were found in some of the tissues containing yttrium and aluminum.

show abstract

The Lanthanides, Rare Earth Elements

Darby

2023

Patty's Toxicology

View full text Add to dashboard Cite

The lanthanides, known also as lanthanoids or rare earth elements (REEs), consist of 17 elements with remarkable properties that have made them emerge in the twenty‐first century as a highly‐valued commodity by the world's industrialized nations. REEs form the largest chemically coherent group in the periodic table. China has led the world production of REEs for decades. The diverse applications of REEs for national defense, energy production and storage, high‐strength magnets, lasers, and medical diagnostics and therapeutics, combined with China's restrictions on supply beginning in 2010, have led to a near‐crisis consisting of national stockpiling, frantic exploration for new deposits, and intense efforts to conserve, recycle and substitute for REEs. The unique physical, chemical and magnetic properties of REEs become particularly interesting at the nanoparticle size, leading to an explosion of research in the last two decades. For these reasons, the commercial and academic pressure to explore new applications of REEs risks outpacing essential research on the toxicology of REEs.

show abstract

Metabolism and Toxicity of Intravenously Injected Yttrium Chloride in Rats

Cited by 56 publications

References 0 publications

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Metallic ions in organs of rats injected with metallic particles of stainless steel 316L and Ti6Al4V alloy

The Lanthanides, Rare Earth Elements

Contact Info

Product

Resources

About