Metabolism and Transport of Glucose and FDG

Application of modern imaging methods in diagnosis of gallbladder cancer

“…These signs are usually detected only in advanced stages of the disease and are relatively non-specific with respect to other benign diseases of the gallbladder [66]. From this base, there has been a gradual development of procedures based on biochemical features of the disease, mainly binding widely bioavailable metabolic substrates to positron-emitting radionuclides, notably fluor-18 bound to [18F]-2-deoxy-D-glucose (FDG) [67].…”

The role of Tc-99m (V) DMSA scintigraphy in the diagnosis and follow-up of lung cancer lesions

“…Malignant and aggressive tumors have acidic pH, show a high glycolysis rate with production of lactic acid, and overexpress hexokinase and glucose transporters (glut 1, glut 3) [17][18][19]. From this point of view, we think that Tc-99m (V) DMSA shows an uptake mechanism that is similar to FDG for malignant tumors, as FDG accumulation in malignant tissue is also mainly due to high glucose utilization, increased hexokinase activity, and increased glucose transporters of the cancer cells [20]. Several studies have suggested that (V) DMSA transport is analogous to phosphate transport in cancer cells [21,22].…”

Standardized uptake values of uterine leiomyoma with 18F-FDG PET/CT: variation with age, size, degeneration, and contrast enhancement on MRI

“…Some earlier reports have described faint or mild 18 F-FDG accumulation in uterine leiomyomas [3,4], whereas others have demonstrated that it often shows signifi cant 18 F-FDG uptake [5][6][7][8]. However, in these studies, only a small number of leiomyomas was investigated, and therefore there has been a need to study a large sample to clarify the baseline clinical tendency for 18 F-FDG accumulation in this type of tumor. The aim of the present study was to assess the relationship of standardized uptake value (SUV) in leiomyomas to age, size, the degree of degeneration, and contrast enhancement on magnetic resonance imaging (MRI).…”

“…Forty-one patients (median age 54.5 years, range 33-86 years) with uterine leiomyomas who had not received any surgery, chemotherapy, or radiation therapy underwent 18 F-FDG-PET/CT and contrast-enhanced MRI with a maximum interval of 7 days between the two examinations between April 2006 and February 2007, after approval from the institutional review board. An informed consent was obtained from each patient after the nature of the procedures had been fully explained.…”

“…Position emission tomography (PET) with 18 F-fl uoro-2-deoxyglucose ( 18 F-FDG) has been widely used for the evaluation of patients with cancer. Although FDG generally accumulates in malignant tumors, it can also accumulate in benign lesions, infl ammatory conditions, and normal organs.…”