2023
DOI: 10.1016/j.ejmech.2023.115666
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Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors

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Cited by 4 publications
(1 citation statement)
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“…Effective delivery of intact drugs to functional targets for action, rather than being hydrolyzed midway, which means that enhanced metabolic stability of the drug is essential for its enhanced efficacy [ 24 ]. Zhu et al assessed the inhibitory activity of Ko143 analogs against ABCG2 by investigating the binding mode, cytotoxicity, and metabolic stability with ABCG2, and found that the amide-modified compounds were more metabolically stable [ 25 ]. Thus, it is a good research idea to help develop new formulations by improving the stability of drug metabolism.…”
Section: Discussionmentioning
confidence: 99%
“…Effective delivery of intact drugs to functional targets for action, rather than being hydrolyzed midway, which means that enhanced metabolic stability of the drug is essential for its enhanced efficacy [ 24 ]. Zhu et al assessed the inhibitory activity of Ko143 analogs against ABCG2 by investigating the binding mode, cytotoxicity, and metabolic stability with ABCG2, and found that the amide-modified compounds were more metabolically stable [ 25 ]. Thus, it is a good research idea to help develop new formulations by improving the stability of drug metabolism.…”
Section: Discussionmentioning
confidence: 99%