Metabolism of 11′‐α‐ and 11′‐γ‐Tocomonoenols in HepG2 Cells Favors the γ‐Congener and Results Predominantly in Carboxymethylbutyl‐Hydroxychromans
Alexander Montoya‐Arroyo,
Viola Brand,
Alexander Kröpfl
et al.
Abstract:ScopeTocomonoenols (T1) are little‐known vitamin E derivatives naturally occurring in foods. Limited knowledge exists regarding the cellular uptake and metabolism of α‐tocomonoenol (αT1) and none about that of γ‐tocomonoenol (γT1).Methods and resultsThe study investigates the cytotoxicity, uptake, and metabolism of αT1 and γT1 in HepG2 cells compared to the α‐ and γ‐tocopherols (T) and ‐tocotrienols (T3). None of the studied tocochromanols are cytotoxic up to 100 µmol L−1. The uptake of the γ‐congeners is sign… Show more
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