Metabolism of 2-methyl-2-(methylthio)propionaldehyde O-methylcarbamoyl)oxime (Temik, UC-21149) in insects

The Toxicologic Effects of the Carbamate Insecticide Aldicarb in Mammals: A Review

“…By the end of the first 24 hr after administration, approximately 90% of two of the labels had been excreted in the urine or as CO2. When rats were fed milk containing radiolabeled Temik metabolites daily for 9 days, approximately 90% of each dose was reported to have been excreted in the urine within a 24-hr period (3). Similarly, Dorough et al (4) fed Holstein cows various concentrations of Temik in the diet and found that 92, 3, and 1% of the dosages were eliminated in the unne, feces, and milk, respectively, indicating almost complete absorption of the administered dose through the gut.…”

“…The metabolism of aldicarb involves both hydrolysis of the carbamate ester and oxidation of the sulfur to the sulfoxide and sulfone derivatives (2). While the hydrolysis results in compounds with little or no insecticidal activity or toxicity to other organisms, the sulfoxide and sulfone metabolites are active cholinesterase inhibitors (2,9,10). Figure 1 shows the metabolic pathways of aldicarb in the rat (11).…”

Comparative Photodegradation Study of Fenthion and Disulfoton under Irradiation of Different Light Sources in Liquid- and Solid-Phases

“…The major metabolism reaction of these pesticides in rats, 25) pigs 26) and insects 27) is the oxygenation of sulfur atom to sulfoxide and a further step to sulfone (O=S=O) by cytochrome P450. Fenthion sulfone was also determined in plants.…”

Metabolism of isofenphos and bendiocarb in southern corn rootworms

“…The identities of these polar metabolites were not examined in the present study. Previous insec ticide metabolism literature (Bull et al, 1967;Metcalf et al, 1968;Kao and Fukuto, 1977), however, reported that these metabolites are com prised of conjugate mixtures. Isopropyl salicylate contains the hydroxyl group as a functional group for conjugation reaction.…”