Metabolism of 99mTc-l,l-Ethyl cysteinate dimer in healthy volunteers

Walovitch, Richard C.; Franceschi, Maja; Picard, Matthieu; Cheesman, Edward H.; Hall, KE; Makuch, J.; Watson, Michael W.B.; Zimmerman, R.E.; Watson, A. D. J.; Ganey, Michael V.; Holman, B. Leonard

doi:10.1016/0028-3908(91)90156-6

Cited by 48 publications

(23 citation statements)

References 5 publications

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“…There was also no difference between the clearance rates for the high and low flow areas of the brain. [4][5][6] Our study showed a variation in Tc-99m ECD retention leading to regional variation in Tc-99m ECD clearance which was in agreement with other reports. 3 • 7 ' 8 We agree that the difference between the retention rates in various studies could be partly due to differences in methods, such as instruments, scan timing, image reconstruction parameters, filters and methods of quantitative measurement and data analysis.…”

Section: Discussionsupporting

confidence: 92%

Retention of Tc-99m ECD in delayed SPECT of the brain

et al. 1999

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We determined the effect of retention on the changes in regional biodistribution of Tc-99m ECD in the brain. A total of 14 cases, 7 normal volunteers and 7 patients with various diagnoses but with very minimal radiologic findings or none were included in the study. SPECT images were taken at 30 min, 1, 2, 3, 4 and 6 hrs after an intravenous injection. Retention rates were calculated in various regions and were corrected according to the time decay of technetium. There was a tendency for the retention rate to increase up to three hours of imaging and then a decrease was noted in most regions of the brain. In the thalamus, increasing retention was noted. In conclusion, Tc-99m ECD retention in the different regions of the brain varies with time. These differences should always be considered when planning and interpreting SPECT quantitative studies.

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Section: Discussionsupporting

confidence: 92%

Retention of Tc-99m ECD in delayed SPECT of the brain

et al. 1999

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“…20 Thus far, neither the corresponding enzyme nor the follow-up products have been identified. 21 A reduction of 99m Tc-ECD uptake by ischemic or infarcted brain areas could therefore be caused by Figure 3. Mean graded SPECT scale score (with 95% CIs) at baseline, 6 to 8 hours after initiation of treatment, and after 7Ϯ1 days in patients with early metabolic recovery after reperfusion within 6 to 8 hours after treatment (nϭ18), with delayed recovery within 7 days after treatment but after 6 to 8 hours (nϭ10), and without recovery (nϭ16) within 7 days as measured by SPECT.…”

Section: Discussionmentioning

confidence: 99%

Reperfusion and Metabolic Recovery of Brain Tissue and Clinical Outcome After Ischemic Stroke and Thrombolytic Therapy

Berrouschot

Barthel

Hesse

et al. 2000

Stroke

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Background and Purpose-It is unclear from recent clinical trials whether thrombolytic agents are capable of facilitating reperfusion and metabolic recovery over time or whether a beneficial effect is counteracted by an increase in the risk of brain hemorrhage. We studied the effect of thrombolytic treatment on metabolic recovery after reperfusion and clinical outcome. Methods-Patients were prospectively studied with

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“…For determining the rCBF, a dose of 550 MBq of 99m Tc-ethyl-cysteine-dimer (ECD) (Neurolite, DuPont Pharma/Durham APS, Kastrup, Denmark) [13]was injected into the subject’s antecubital vein. The single photon emission computed tomography (SPECT) scan was carried out 45 min later with a three-headed Siemens MultiSPECT 3 gamma camera equipped with fan beam collimators (Siemens Medical Systems, Hoffman Estates, Ill., USA) [14].…”

Section: Methodsmentioning

confidence: 99%

Serum Leptin and Regional Cerebral Blood Flow during Exposure to Food in Obese and Normal-Weight Women

Karhunen

Lappalainen²,

Vanninen³

et al. 1999

Neuroendocrinology

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Leptin is an adipocyte-derived product of the ob gene thought to be involved in the regulation of eating. Receptors for leptin have been found in multiple regions in the brain. In particular, hypothalamic receptors seem to be of fundamental importance for the biological effects of leptin. However, the association of leptin with cerebral function in humans has not been studied. Therefore, in order to assess the possible functional relationships between leptin and cerebral activity in humans, simultaneous serum leptin and regional cerebral blood flow (rCBF) measurements were made in 10 obese [BMI 33.5 (29.3–39.1) kg/m²] and 12 normal-weight [BMI 22.2 (20.3–24.6) kg/m²] women during exposure to food. The rCBF measurements were performed by ^99mTc-ethyl-cysteine-dimer single photon emission computed tomography. A strong inverse association was observed between the leptin and rCBF of hypothalamus during the exposure to food in the obese (r = –0.73, p = 0.02, n = 10), but not in the normal-weight subjects (r = 0.22, p = 0.48, n = 12). This suggests that the association of leptin with cerebral activity could be different in obese and normal-weight women; depressed activity of hypothalamic neurones in response to the high peripheral leptin concentration could be postulated to occur in obese women during exposure to food.

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Metabolism of 99mTc-l,l-Ethyl cysteinate dimer in healthy volunteers

Cited by 48 publications

References 5 publications

Retention of Tc-99m ECD in delayed SPECT of the brain

Retention of Tc-99m ECD in delayed SPECT of the brain

Reperfusion and Metabolic Recovery of Brain Tissue and Clinical Outcome After Ischemic Stroke and Thrombolytic Therapy

Serum Leptin and Regional Cerebral Blood Flow during Exposure to Food in Obese and Normal-Weight Women

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