Metabolism of captopril carboxyl ester derivatives for percutaneous absorption

Abstract

In-vitro porcine liver esterase metabolism rates inform in-vitro skin rates well, and in-silico interaction energies relate well to both. Thus, in-silico methods may be developed that include interaction energies to predict metabolism rates.

The Contributions of the Celtic Masters and Their Associates

“…This work was elaborated on by the use of discriminant analysis as a tool to optimize the selection and formulation of chemical penetration enhancers for transdermal drug delivery [78]. Subsequently, Pugh applied several of these modelling methods to a number of formulation-based studies, including the design and formulation of prodrugs of captopril [79,80,81] and the use of 1,8-cineole to enhance the transdermal delivery of haloperidol from gel formulations [82]. …”