“…Similarly, Hindmarch and Gudgeon (1 983) found no evidence of any sedative effect of chlormezanone after a single administration of 200 mg using a test battery of established sensitivity to the sedative effects of benzodiazepines (Wittenborn, 1979;Hindmarch, 1980;Johnson and Chernik, 1982). However this negative result may be due to the fact that the authors did not take into account the pharmacokinetics of the compound, and evaluated its phannacodynamic activity one hour after administration while the C, , , occurs between 2 hours (McChesney et al, 1967) and 4 hours after dosing (Ohya et al, 1980). In contrast, Hindmarch and Gudgeon found that the repeated administration of 600 mg per day for 5 days caused a significant decrease in performance on the digit symbol substitution test as well as a subjective feeling of tiredness.…”