Metabolism of citrulline in man

Rabier, Daniel; Kamoun, P.

doi:10.1007/bf00807268

Cited by 121 publications

(93 citation statements)

References 74 publications

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“…They later established that the small intestine is the major source of circulating citrulline in the adult rat [20]. The small intestine of the dog [69] and pig [70], as well as the portal-drained viscera of the human [71] and sheep [72], also release relatively large amounts of citrulline. The enterocyte is the cell type responsible for intestinal synthesis of citrulline or arginine from glutamine\ glutamate [73][74][75].…”

Section: Intestinal Arginine Synthesismentioning

confidence: 99%

Arginine metabolism: nitric oxide and beyond

Morris

1998

Biochemical Journal

2,450

2,036

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Arginine is one of the most versatile amino acids in animal cells, serving as a precursor for the synthesis not only of proteins but also of nitric oxide, urea, polyamines, proline, glutamate, creatine and agmatine. Of the enzymes that catalyse rate-controlling steps in arginine synthesis and catabolism, argininosuccinate synthase, the two arginase isoenzymes, the three nitric oxide synthase isoenzymes and arginine decarboxylase have been recognized in recent years as key factors in regulating newly identified aspects of arginine metabolism. In particular, changes in the activities of argininosuccinate synthase, the arginases, the inducible isoenzyme of nitric oxide synthase and also cationic amino acid transporters play major roles in determining the metabolic fates of arginine in health and disease, and recent studies have identified

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Section: Intestinal Arginine Synthesismentioning

confidence: 99%

Arginine metabolism: nitric oxide and beyond

Morris

1998

Biochemical Journal

2,450

2,036

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“…Аргиназы -основные потребители ар-гинина. NOS и аргининдекарбоксилаза-агматин зависимые пути метаболизма отвечают только за небольшой процент тотального ежедневного оборота этой аминокислоты [5,83,85].…”

Section: метаболизм аргинина в эукариотических клет-кахunclassified

“…Роль метаболизма аргинина в регуляции иммун-ного ответа В настоящее время в литературе накопле-но большое количество данных, доказывающих важную роль метаболизма аргинина в регуляции функций клеток иммунной системы. Большин-ство этих результатов получены в исследованиях по изучению дефицита аргинина, вызванного активностью аргиназ [9,83]. Последствия депри-вации аргинина под влиянием АД для работы иммунной системы и осуществления защитных реакций организма-хозяина изучены недостаточ- Моноциты и макрофаги представляют со-бой важный компонент врожденного иммуни-тета, т.е.…”

Section: иммуносупрессорные эффекты аргининдеиминазыunclassified

“…На мышах, нокаутированных по гену циклина D3, было показано, что он не-обходим для созревания и для пролиферации T-клеток в тимусе. T-клетки, культивируемые в отсутствие L-Arg, вследствие ингибиции ци-клина D3, имели значительно сниженный уро-вень фосфорилирования pRb и низкий уровень ядерной транслокации транскрипционного фак-тора E2F-1 [65,83].…”

Section: влияние дефицита аргинина на функции эндо-телиальных клетокunclassified

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Immunosuppressive Effects of Arginine Deiminase From Streptococcus Pyogenes

Старикова¹,

Соколов²,

Bürova³

et al. 2015

Med. immunol.

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“…The provided reviews (Curis et al, 2005;Gibala et al, 1997;Rabier and Kamoun, 1995;Vanuxem et al, 1986) contained no primary data which could be used for the scientific substantiation of the claim.…”

Section: Scientific Substantiation Of the Claimed Effectmentioning

confidence: 99%

Scientific Opinion on the substantiation of a health claim related to citrulline malate and faster recovery from muscle fatigue after exercise pursuant to Article 13(5) of Regulation (EC) No 1924/2006

Publication¹

2012

EFSA Journal

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European Food Safety Authority (EFSA), Parma, Italy ABSTRACTFollowing an application from Biocodex, submitted pursuant to Article 13(5) of Regulation (EC) No 1924No /2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to citrulline-malate and faster recovery from muscle fatigue after exercise. Citrulline-malate is sufficiently characterised. The claimed effect is "maintenance of ATP levels through reduction of lactates in excess for an improved recovery from muscle fatigue". The target population proposed by the applicant is healthy children above six years of age and adults. The Panel considers that faster recovery from muscle fatigue after exercise contributing to the restoration of muscle function is a beneficial physiological effect. A total of 33 references were considered as pertinent to the claim by the applicant. A number of studies were provided with hospitalised patients or outpatients who presented with various forms of asthenia or fatigue. No conclusions could be drawn from these studies for the scientific substantiation of the claim. No conclusions could be drawn from one study carried out in athletes, owing to the methodological limitations of the study. A number of mechanistic, animal and in vitro studies were submitted. In the absence of evidence for an effect of consumption of citrulline-malate on a faster recovery from muscle fatigue after exercise in humans, these studies cannot be used as a source of data for the scientific substantiation of the claim as their results cannot predict the occurrence of an effect of citrulline-malate on recovery from muscle fatigue after exercise in vivo in humans. The Panel concludes that a cause and effect relationship has not been established between the consumption of citrulline-malate and faster recovery from muscle fatigue after exercise. © European Food Safety Authority, 2012 KEY WORDSCitrulline-malate, muscle fatigue, exercise, health claims The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence and including a request for the protection of proprietary data.The food constituent that is the subject of the health claim is citrulline-malate, which is a mixture of L-citrulline and D,L-malic acid (1:1) forming a salt. The Panel considers that citrulline-malate is sufficiently characterised.The claimed effect is "maintenance of ATP levels through reduction of lactates in excess for an improved recovery from muscle fatigue". The target population proposed by the applicant is healthy children above six years of age and adults. The Panel considers that faster recovery from muscle fatigue after exercise contributing to the restoration of muscle function is a beneficial physiological effect.A total of 33 references were considered as pertinent to the claim by the applicant. These references comprised 18 human studies, four animal studies, seven in vitro studies, and f...

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Metabolism of citrulline in man

Cited by 121 publications

References 74 publications

Arginine metabolism: nitric oxide and beyond

Arginine metabolism: nitric oxide and beyond

Immunosuppressive Effects of Arginine Deiminase From Streptococcus Pyogenes

Scientific Opinion on the substantiation of a health claim related to citrulline malate and faster recovery from muscle fatigue after exercise pursuant to Article 13(5) of Regulation (EC) No 1924/2006

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