Metabolism of essential fatty acids and prostaglandin biosynthesis in man

Abstract

Linoleic and linolenic acids are precursors for the biosynthesis of prostaglandins (PG) and related compounds. In man augmented linoleic acid intake results in stimulation of PG-biosynthesis, for PG originating from the kidney a stimulation only is found for PGE2. Dietary linolenic acid inhibits PG biosynthesis to a tenfold lesser degree than eicosapentaenoic acid. Renal PGE2 is depressed by linolenic acid intake, while no effect is found for PGF2 alpha up to 8 energy% of linolenic acid supply. Linoleic and linolenic acids additionally display effects on fatty acid metabolism. In contrast to the results of in vitro studies the supply with the precursor linoleic acid results in a decrease of arachidonic acid in cholesterolesters of plasma and in HDL-lecithin, while the intake of linolenic acid is without effect. From these data it is concluded that in vivo the conversion of linoleic to arachidonic acid occurs preferentially to the analogous conversion of linolenic to eicosapentaenoic acid.

Empirische Untersuchungen zur Progressionsminderung der Multiplen Sklerose durch eine ergänzende bilanzierte Diät

“…Da eine Resorptionssto È rung nicht vorliegt, wurde dieser Befund als Selbstschutzmechanismus zur Begrenzung der Entzu È ndungen interpretiert [15]. Des Weiteren wurde gezeigt, dass die Prostaglandinsynthese durch die Erho È hung der Linolsa È urezufuhr stimuliert wird [1]. Im Gegensatz zu vielen anderen Organen findet in ZNS-Anteilen eine betra È chtliche Umwandlung von Linolsa È ure in Arachidonsa È ure statt, insbesondere in Astrozyten [14].…”

Fatty acid composition of the diet: impact on serum lipids and atherosclerosis

“…There is some evidence that different prostaglandins react differently to changes in dietary linoleic acid [5]. There is some evidence that different prostaglandins react differently to changes in dietary linoleic acid [5].…”