Metabolism of Formaldehyde In Vivo

Xiao, Rong; He, Rong

doi:10.1007/978-94-024-1177-5_2

Formaldehyde and Cognition 2017

DOI: 10.1007/978-94-024-1177-5_2

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Metabolism of Formaldehyde In Vivo

Rong Xiao

Rong He

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2024

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Cited by 2 publications

References 111 publications

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Antioxidants as Protection against Reactive Oxygen Stress Induced by Formaldehyde (FA) Exposure: A Systematic Review

Ungureanu,

Ghiciuc,

Amalinei

et al. 2024

Biomedicines

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Background and Objectives: Formaldehyde induces oxidative stress and is carcinogenic, particularly squamous cell carcinoma of the nasopharyngeal area. Around us, in exhaust gases, cigarette smoke, and various industrial products, FA primarily affects the respiratory tract and other organs like the cornea, liver, kidneys, brain, and cardiovascular system. This study aims to determine if antioxidants can mitigate FA’s harmful effects. Materials and Methods: Several databases, including PubMed, Science Direct, Springer, and Wiley, were systematically searched. Research publications on antioxidants mitigating FA-induced oxidative damage were included, but reviews and articles lacking complete texts were excluded. SYRCLE’s risk of bias tool for animal studies has been used. Tables were used for data synthesis. Out of 8790 articles, 35 publications detailing tissue homogenate for biochemical analysis, standard hematoxylin–eosin staining, and immunohistochemistry markers for histopathological and immunohistochemical diagnosis were selected. Most studies were case–control studies, utilizing rat or mouse models. Additionally, one cohort study on industrial workers was analyzed. Conclusions: Antioxidants, including plant extracts, vitamins, and pigments, can prevent or heal FA-induced lesions. However, human studies, particularly biopsies, remain challenging, and animal trials are limited. Further research is needed to confirm FA’s long-term effects and optimize antioxidant dosages.

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Antioxidants as Protection against Reactive Oxygen Stress Induced by Formaldehyde (FA) Exposure: A Systematic Review

Ungureanu,

Ghiciuc,

Amalinei

et al. 2024

Biomedicines

View full text Add to dashboard Cite

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Formaldehyde and De/Methylation in Age-Related Cognitive Impairment

Li¹,

Wei

et al. 2021

Genes

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Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-compounds, such as DNA, RNA, and amino acids. Endogenous FA plays a role in epigenetic regulation, especially in the methylation and demethylation of DNA, histones, and RNA. Recently, epigenetic alterations associated with FA dysmetabolism have been considered as one of the important features in age-related cognitive impairment (ARCI), suggesting the potential of using FA as a diagnostic biomarker of ARCI. Notably, FA plays multifaceted roles, and, at certain concentrations, it promotes cell proliferation, enhances memory formation, and elongates life span, effects that could also be involved in the aetiology of ARCI. Further investigation of and the regulation of the epigenetics landscape may provide new insights about the aetiology of ARCI and provide novel therapeutic targets.

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Metabolism of Formaldehyde In Vivo

Cited by 2 publications

References 111 publications

Antioxidants as Protection against Reactive Oxygen Stress Induced by Formaldehyde (FA) Exposure: A Systematic Review

Antioxidants as Protection against Reactive Oxygen Stress Induced by Formaldehyde (FA) Exposure: A Systematic Review

Formaldehyde and De/Methylation in Age-Related Cognitive Impairment

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