Metabolism of selenate and selenomethionine by a selenium-deficient population of men in China

Xia, Yiming; Zhao, Xin‐Quan; Zhu, L.; Whanger, P. D.

doi:10.1016/0955-2863(92)90041-g

Cited by 47 publications

(18 citation statements)

References 27 publications

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“…On the other hand, supplementation of New Zealanders with a plasma selenium level of 0.7 mmol/l with 200 mg/d selenium as selenate or selenium-rich yeast, resulted in increased plasma glutathione peroxidase activities plateauing at selenium concentrations of 1.2 mmol/l and 2.5 mmol/l, respectively (Thomson et al, 1993). In Chinese men with a plasma selenium concentration of 0.3 mmol/l, supplementation with 200 mg/d as sodium selenate or selenium-rich yeast resulted in similar increases in plasma glutathionine peroxidase in both groups, reaching plateaus at plasma selenium concentrations of 0.9 mmol/l and 1.4 mmol/l, respectively (Xia et al, 1992). Moreover, when plasma glutathione peroxidase and selenium data from different cross-sectional studies were combined, a tendency towards a plateau of plasma glutathione peroxidase was reached at a plasma selenium concentration of approximately 1 mmol/l (Huang, 1996).…”

Section: Discussionmentioning

confidence: 81%

Plasma selenoprotein P levels of healthy males in different selenium status after oral supplementation with different forms of selenium

1998

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Objective: To assess changes in selenoprotein P levels in plasma from subjects who had received oral supplements of different selenium forms. Design: The same study group participated in two similar selenium supplementation trials, Trial I in 1981(Levander et al, 1983 and Trial II in 1987(Alfthan et al, 1991. During Trial II the mean baseline intake of selenium in Finland was higher compared to that during Trial I (100 and 40 mg/d, respectively), due to a nationwide supplementation of fertilisers which started in 1985. Subjects: Fifty healthy Finnish men, 36±60 y old. Intervention: The study group received daily placebo or oral supplements consisting of 200 mg selenium as selenium-enriched yeast, sodium selenate or selenium-enriched wheat (Trial I) or selenium-enriched yeast, sodium selenate or sodium selenite (Trial II). The duration of supplementation periods was 11 (Trial I) and 16 (Trial II) weeks. Results: In Trial I the mean plasma selenoprotein P values in all the supplemented groups increased signi®cantly, approaching a plateau at 2 weeks and reaching maxima at 4 weeks (mean increase 34%, P`0.05). In Trial II the mean selenoprotein P levels of the supplemented groups were not signi®cantly different from each other or from the placebo group at the start or at any time point of the supplementation period. Conclusions: At a low selenium status the selenoprotein P levels increased in a similar fashion after supplementation with different forms of selenium, but at a high selenium status no signi®cant effects of supplementation with the same amount of selenium were observed. No differences in selenoprotein P levels were observed for inorganic and organic selenium supplements.

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Section: Discussionmentioning

confidence: 81%

Plasma selenoprotein P levels of healthy males in different selenium status after oral supplementation with different forms of selenium

1998

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“…Maximum activity of GSH-Px is already achieved at the Se level of 0.1 mg/kg of fodder in the case of both organic and inorganic form. This activity is independent on the chemical form (Xia et al 1992).…”

Section: Selenium Sources and Their Efficiencymentioning

confidence: 86%

Selenium in poultry nutrition: a review

Suchý¹,

Straková²,

Herzig³

2014

Czech J. Anim. Sci.

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Selenium has been known for two centuries and its biological activities have been studied for nearly a hundred years, however the problem of Se deficit has still been persisting both in humans and animals. The cause of Se deficit in animals may be low Se level in soil. This mainly applies to cattle and sheep with their direct link to soil via roughage. The risk of Se deficit in pigs and poultry is lower due to lower dependence on soil Se level in the region and Se fortification in feed mixes. The present research focuses on the effects of Se on meat and egg quality, antioxidant activity of Se, effects on fatty acid levels, activity of glutathione-peroxidase, or the effect of Se on the immune system. Ensuring natural Se supply in human nutrition by food of animal origin, mainly poultry meat and eggs (the "functional foods"), is another area to which extensive attention has recently been paid.

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“…Se-Met is readily absorbed, and results in higher blood Se concentration than inorganic Se, whereas GSHPx activity seems to be unaffected by the chemical form of dietary Se (Xia et al 1992).…”

Section: Chemical Formmentioning

confidence: 99%