Metabolism of some Industrial Uranium Tetrafluorides after Deposition in the Rat Lung

Stradling, G.N.; Stather, J.W.; Strong, John; Sumner, S.A.; Towndrow, C.G.; Moody, J.C.; Lennox, Aileen M.; Sedgwick, Daniel; Cooke, N.

doi:10.1177/096032718500400206

Cited by 20 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reported biokinetic behaviour of UF 4 is complex. Measurement of urinary excretion after inhalation by workers (Chalabreysse et al., 1989) and experiments in rats and baboons (Stradling et al., 1985a; André et al., 1989; Ansoborlo et al., 1990) showed that a large fraction (35–40%) of the lung deposit was absorbed to the blood by 7 d after administration. However, considerable variations in behaviour were observed, with some experiments indicating assignment to default Type F and others to default Type M. (844) Zhao and Zhao (1990) reported measurements of urinary excretion of uranium made for 3 y after an accidental inhalation of UF 4 powder by a worker.…”

Section: Uranium (Z = 92)mentioning

confidence: 99%

“…The unusual behaviour may have been caused, in part, by the size of the intake, which was sufficient to give rise to biochemical indications of kidney dysfunction. (845) Hodgson et al. (2000) derived absorption parameter values from the results of a study by Stradling et al. (1985a) in which the biokinetic of uranium in rats were followed for 360 d after inhalation and 168 d after intratracheal administration of two forms of UF 4 : (i) f r = 0.51, s r = 0.10 d −1 , and s s = 0.0074 d −1 ; and (ii) f r = 0.52, s r = 0.11 d −1 , and s s = 0.0039 d −1 .…”

Section: Uranium (Z = 92)mentioning

confidence: 99%

See 1 more Smart Citation

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

Paquet¹,

Bailey²,

Leggett³

et al. 2017

Ann ICRP

234

View full text Add to dashboard Cite

The 2007 Recommendations of the International Commission on Radiological Protection (ICRP, 2007) introduced changes that affect the calculation of effective dose, and implied a revision of the dose coefficients for internal exposure, published previously in the Publication 30 series (ICRP, 1979, 1980, 1981, 1988) and Publication 68 (ICRP, 1994). In addition, new data are now available that support an update of the radionuclide-specific information given in Publications 54 and 78 (ICRP, 1988a, 1997b) for the design of monitoring programmes and retrospective assessment of occupational internal doses. Provision of new biokinetic models, dose coefficients, monitoring methods, and bioassay data was performed by Committee 2, Task Group 21 on Internal Dosimetry, and Task Group 4 on Dose Calculations. A new series, the Occupational Intakes of Radionuclides (OIR) series, will replace the Publication 30 series and Publications 54, 68, and 78. OIR Part 1 has been issued (ICRP, 2015), and describes the assessment of internal occupational exposure to radionuclides, biokinetic and dosimetric models, methods of individual and workplace monitoring, and general aspects of retrospective dose assessment. OIR Part 2 (ICRP, 2016), this current publication and upcoming publications in the OIR series (Parts 4 and 5) provide data on individual elements and their radioisotopes, including information on chemical forms encountered in the workplace; a list of principal radioisotopes and their physical half-lives and decay modes; the parameter values of the reference biokinetic model; and data on monitoring techniques for the radioisotopes encountered most commonly in workplaces. Reviews of data on inhalation, ingestion, and systemic biokinetics are also provided for most of the elements. Dosimetric data provided in the printed publications of the OIR series include tables of committed effective dose per intake (Sv Bq−1 intake) for inhalation and ingestion, tables of committed effective dose per content (Sv Bq−1 measurement) for inhalation, and graphs of retention and excretion data per Bq intake for inhalation. These data are provided for all absorption types and for the most common isotope(s) of each element. The electronic annex that accompanies the OIR series of publications contains a comprehensive set of committed effective and equivalent dose coefficients, committed effective dose per content functions, and reference bioassay functions. Data are provided for inhalation, ingestion, and direct input to blood. This third publication in the series provides the above data for the following elements: ruthenium (Ru), antimony (Sb), tellurium (Te), iodine (I), caesium (Cs), barium (Ba), iridium (Ir), lead (Pb), bismuth (Bi), polonium (Po), radon (Rn), radium (Ra), thorium (Th), and uranium (U).

show abstract

Section: Uranium (Z = 92)mentioning

confidence: 99%

Section: Uranium (Z = 92)mentioning

confidence: 99%

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

Paquet¹,

Bailey²,

Leggett³

et al. 2017

Ann ICRP

234

View full text Add to dashboard Cite

show abstract

“…These variations relate to the experimental protocol, oxygenation of the solvents, etc. (18,19), or to the physical characteristics of the compounds (3). The in vitro technique, using specialized cells such as alveolar macrophages, markedly reduced the influence of these different parameters because it simulated the long-term in vivo intracellular dissolution ofparticles deposited in alveoli and phagocytized by macrophages (16,17,20).…”

Section: Discussionmentioning

confidence: 99%

In vitro dissolution of uranium oxide by baboon alveolar macrophages.

Poncy

Métivier

Dhilly

et al. 1992

Environ Health Perspect

View full text Add to dashboard Cite

In vitro cellular dissolution tests for insoluble forms of uranium oxide are technically difficult with conventional methodology using adherent alveolar macrophages. The limited number of cells per flask and the slow dissolution rate in a large volume of nutritive medium are obvious restricting factors. Macrophages in suspension cannot be substituted because they represent different and poorly reproducible functional subtypes with regard to activation and enzyme secretion. Preliminary results on the dissolution of uranium oxide using immobilized alveolar macrophages are promising because large numbers of highly functional macrophages can be cultured in a limited volume. Cells were obtained by bronchoalveolar lavages performed on baboons (Papio papio) and then immobilized after the phagocytosis of uranium octoxide (U3O8) particles in alginate beads linked with Ca2+. The dissolution rate expressed as percentage of initial uranium content in cells was 0.039 +/- 0.016%/day for particles with a count median geometric diameter of 3.84 microns(sigma g = 1.84). A 2-fold increase in the dissolution rate was observed when the same number of particles was immobilized without macrophages. These results, obtained in vitro, suggest that the U3O8 preparation investigated should be assigned to inhalation class Y as recommended by the International Commission on Radiological Protection. Future experiments are intended to clarify this preliminary work and to examine the dissolution characteristics of other particles such as uranium dioxide. It is recommended that the dissolution rate should be measured over an interval of 3 weeks, which is compatible with the survival time of immobilized cells in culture and may reveal transformation states occurring with aging of the particles.

show abstract

“…Table 3.2. Leach et al 1973;Cook and Holt 1974;Pomroy and Noel 1981;Schieferdecker et al 1985;Price 1989;Stradling et al 1989b;Métivier et al 1992;Eidson 1994;Chazel et al 2000b;Ansoborlo et al 2002;Stradling et al 2002 Uranium West et al 1979;Eidson and Mewhinney 1980;Chalabreysse et al 1989;Stradling et al 1989aStradling et al , 2002Eidson 1990Eidson , 1994Métivier et al 1992;Barber and Forrest 1995;Ansoborlo et al 1998bAnsoborlo et al , 2002Chazel et al 1998 Uranium Stradling et al 1985Stradling et al , 2002Chalabreysse et al 1989;André et al 1989;Ansoborlo et al 1990Ansoborlo et al , 2002Eidson 1994;Chazel et al 2000a Uranium Galibin and Parfenov 1971;Cook and Holt 1974;Boback 1975;Eidson and Mewhinney 1980;Damon et al 1984;Stradling et al 1987Stradling et al , 2002Eidson 1994;Ansoborlo et al 2002 In vitro studies indicate dissolution rate varies with mixture of materials and preparation process. Differences found in dissolution rates of low-fired yellowcake (dried at less than 400° C) and high-fired (calcined) yellowcake (dried at 4...…”

Section: Application Of the Hrtm To Various Forms Of Uraniummentioning

confidence: 99%

Controlling intake of uranium in the workplace: Applications of biokinetic modeling and occupational monitoring data

Leggett¹,

Eckerman²,

McGinn³

et al. 2012

View full text Add to dashboard Cite

This report provides methods to interpret and apply occupational uranium monitoring data. The methods are based on current international radiation protection guidance, current information on the chemical toxicity of uranium, and best available biokinetic models for uranium. Emphasis is on air monitoring data and three types of bioassay data: the concentration of uranium in urine; the concentration of uranium in feces; and the externally measured content of uranium in the chest. Primary Reference guidance levels for prevention of chemical effects and limitation of radiation effects are selected based on a review of current scientific data and regulatory principles for setting standards. Generic investigation levels and immediate action levels are then defined in terms of these primary guidance levels. The generic investigation and immediate actions levels are stated in terms of radiation dose and concentration of uranium in the kidneys. These are not directly measurable quantities, but models can be used to relate the generic levels to the concentration of uranium in air, urine, or feces, or the total uranium activity in the chest. Default investigation and immediate action levels for uranium in air, urine, feces, and chest are recommended for situations in which there is little information on the form of uranium taken into the body. Methods are prescribed also for deriving case-specific investigation and immediate action levels for uranium in air, urine, feces, and chest when there is sufficient information on the form of uranium to narrow the range of predictions of accumulation of uranium in the main target organs for uranium: kidneys for chemical effects and lungs for radiological effects. In addition, methods for using the information herein for alternative guidance levels, different from the ones selected for this report, are described. v FOREWORDThis report provides a detailed description of uranium biokinetics and bioassays applicable to evaluation of health risks from potential intakes in an occupational setting. The report addresses both the radiotoxicity and chemical (renal) toxicity of uranium. For reference occupational exposure scenarios, predictions of the time-dependent concentration of uranium in tissues and bioassay are based on biokinetic models currently recommended by the International Commission on Radiological Protection (ICRP). The ICRP's models and default assumptions for uranium were based primarily on data for human subjects exposed to uranium in controlled studies or in occupational or environmental settings. In addition, the ICRP considered an extensive database for uranium in laboratory animals. Sensitivity studies examine the robustness of these models and assumptions to ensure that radiation doses and accumulation of uranium in the kidneys are not underestimated. For example, analyses indicate that a default 5 µm activity median aerodynamic diameter particle size can lead to an underestimation of radiation dose as well as the concentration of uranium in the kidneys if inhal...

show abstract

Metabolism of some Industrial Uranium Tetrafluorides after Deposition in the Rat Lung

Cited by 20 publications

References 9 publications

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

In vitro dissolution of uranium oxide by baboon alveolar macrophages.

Controlling intake of uranium in the workplace: Applications of biokinetic modeling and occupational monitoring data

Contact Info

Product

Resources

About