2017
DOI: 10.1021/acs.jafc.7b02575
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Metabolism of T-2 Toxin in Farm Animals and Human In Vitro and in Chickens In Vivo Using Ultra High-Performance Liquid Chromatography- Quadrupole/Time-of-Flight Hybrid Mass Spectrometry Along with Online Hydrogen/Deuterium Exchange Technique

Abstract: After being incubated with animal and human liver microsomes, metabolites of phase I and II were investigated. A comparison was performed by ultrahigh performance liquid chromatography-quadrupole/time-of-flight coupled to mass spectrometry (UHPLC-Q/TOF). Consequently, a total of four phase I metabolites and three glucuronide binding metabolites of T-2 toxin were discovered. Although a significant metabolic difference was observed among six species, HT-2 toxin was the major product in all species. In addition, … Show more

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Cited by 21 publications
(33 citation statements)
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“…Except for the existence of NEO-3Glc in human cells, there were no significant metabolic distinctions between rat and human cells (Yang et al 2017b). In a study on the two-phase metabolism of T-2, three glucuronides were detected: T2-3-GlcA, HT-2-3-glucuronide (HT2-3-GlcA), and HT2-4-GlcA (Yang et al 2017a). HT2-3-GlcA was discovered as the primary form in humans, rats, and porcine hepatocytes, but traces of HT2-4-GlcA and T2-3-GlcA were also found.…”
Section: In Vitro Metabolismmentioning
confidence: 94%
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“…Except for the existence of NEO-3Glc in human cells, there were no significant metabolic distinctions between rat and human cells (Yang et al 2017b). In a study on the two-phase metabolism of T-2, three glucuronides were detected: T2-3-GlcA, HT-2-3-glucuronide (HT2-3-GlcA), and HT2-4-GlcA (Yang et al 2017a). HT2-3-GlcA was discovered as the primary form in humans, rats, and porcine hepatocytes, but traces of HT2-4-GlcA and T2-3-GlcA were also found.…”
Section: In Vitro Metabolismmentioning
confidence: 94%
“…HT2-3-GlcA was discovered as the primary form in humans, rats, and porcine hepatocytes, but traces of HT2-4-GlcA and T2-3-GlcA were also found. In the liver cells of cows and goats, HT2-4-GlcA was the predominant metabolite, and both produced traces of HT2-3-GlcA and T2-3-GlcA (Yang et al 2017a). The glucuronide conjugation of T-2 showed significant metabolic differences across species, and the glucuronidation ability of swine was the strongest, followed by that of rats, goats, cows, and humans (Yang et al 2017a).…”
Section: In Vitro Metabolismmentioning
confidence: 98%
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