Metabolism of the phenolic antioxidant 3,5-Di-tert-butyl-4-hydroxyanisole (Topanol 354). II. Biotransformation in man, rat and dog

Daniel, J.W.; Green, T.; Phillips, P. J.

doi:10.1016/0015-6264(73)90136-3

Food and Cosmetics Toxicology

1973

DOI: 10.1016/0015-6264(73)90136-3

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Metabolism of the phenolic antioxidant 3,5-Di-tert-butyl-4-hydroxyanisole (Topanol 354). II. Biotransformation in man, rat and dog

J.W. Daniel¹,

T. Green²,

P. J. Phillips³

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1983

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Cited by 3 publications

References 14 publications

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A new metabolite of butylated hydroxyanisole in man

El-Rashidy

Niazi

1983

Biopharm & Drug Disp

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Butylated hydroxyanisole (I) is one of the most commonly used food antioxidants. Its use has been suggested to inhibit a variety of carcinogenic responses. The present study on the disposition kinetics of (I) in man indicates that contrary to previous reports, (I) undergoes significant O-demethylation in the body yielding a tert-butyl hydroquinone. It is suggested that this metabolic conversion may be responsible for some of the in vivo activities of (I) against chemical carcinogens.

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A new metabolite of butylated hydroxyanisole in man

El-Rashidy

Niazi

1983

Biopharm & Drug Disp

View full text Add to dashboard Cite

show abstract

Metabolism of the phenolic antioxidant 3,5-di-tert-butyl-4-hydroxyanisole (Topanol 354). III. The metabolism in rats of the major autoxidation product, 2,6-di-tert-butyl-p-benzoquinone

Daniel¹,

Green²,

Phillips³

1973

Food and Cosmetics Toxicology

View full text Add to dashboard Cite

Metabolism of the phenolic antioxidant 3,5-Di-tert-butyl-4-hydroxyanisole (topanol 354). III. The metabolism in rats of the major autoxidation product, 2,6-Di-tert-butyl-p-benzoquinone

Daniel¹,

Green²,

Phillips³

1973

Food and Cosmetics Toxicology

View full text Add to dashboard Cite

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Metabolism of the phenolic antioxidant 3,5-Di-tert-butyl-4-hydroxyanisole (Topanol 354). II. Biotransformation in man, rat and dog

Cited by 3 publications

References 14 publications

A new metabolite of butylated hydroxyanisole in man

A new metabolite of butylated hydroxyanisole in man

Metabolism of the phenolic antioxidant 3,5-di-tert-butyl-4-hydroxyanisole (Topanol 354). III. The metabolism in rats of the major autoxidation product, 2,6-di-tert-butyl-p-benzoquinone

Metabolism of the phenolic antioxidant 3,5-Di-tert-butyl-4-hydroxyanisole (topanol 354). III. The metabolism in rats of the major autoxidation product, 2,6-Di-tert-butyl-p-benzoquinone

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