Metabolism of the Uterus of the Rat During Early Pseudopregnancy and Its Regulation by Estrogen and Progestogen

Saldarini, Ronald J.; Yochim, J. M.

doi:10.1210/endo-80-3-453

Cited by 17 publications

(12 citation statements)

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“…3) and, perhaps, to the observed changes in oxidative metabolism as well (Saldarini & Yochim, 1967). The gradually increased rate of glycogen synthesis and turnover which occurs in the uterus during this period could provide ample endogenous substrate for both anaerobic and oxidative metabolism, and would be consistent with the present data (Boettiger, 1946;Rosenbaum & Goolsby, 1957;Kostyo, 1957;Rubulis, Jacobs & Hughes, 1965).…”

Section: Discussionsupporting

confidence: 88%

“…3), perhaps because of a relative deficiency of glycogen (Boettiger, 1946;Kostyo, 1957;Rubulis et al, 1965;Moulton & Leonard, 1966) (Kerly, 1937(Kerly, , 1940Saldarini & Yochim, 1967;Khayyal & Scott, 1935a, b).…”

Section: Discussionmentioning

confidence: 99%

“…1 and 3). These data may be a reflection of a continued deficiency of endogenous substrate in the myometrium during pseudopregnancy (Boettiger, 1946, Connolly, Bitman, Cecil & Wrenn, 1962 and of a possible requirement, therefore, for increased glucose uptake which is used for both glycolytic and oxidative purposes (Saldarini & Yochim, 1967, 1968 (Text- fig. 3).…”

Section: Discussionmentioning

confidence: 99%

“…Experiments were carried out to study glucose utilization in the myometrium of the rat during early pseudopregnancy, and its regulation by ovarian steroids at dose levels which can maintain other parameters of progestation during this time (Saldarini & Yochim, 1967 J. M. Yochim and R. J. Saldarini endometrium and sub-endometrial stroma were scraped gently from each horn. Representative portions (30 to 50 mg) of myometrium were taken from each horn and sliced longitudinally on a Stadie-Riggs tissue slicer.…”

Section: Introductionmentioning

confidence: 99%

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Glucose Utilization by the Myometrium During Early Pseudopregnancy in the Rat

Yochim¹,

Saldarini²

1969

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Glucose Utilization by the Myometrium During Early Pseudopregnancy in the Rat

Yochim¹,

Saldarini²

1969

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“…In addition, our interest Numerous studies have appeared that dem onstrate changes in the metabolic activity of the uterus during the estrous cycle in rats (2,(8)(9)(10). However, fewer reports can be found on comparable studies in primates, and many of these were directed towards the effects of hormonal contraceptives (11).…”

mentioning

confidence: 99%

Enzyme Activities in Human Endometrium, Myometrium and Leiomyomas of the Uterus

Maggiulli¹,

Gustafson²,

Rector³

et al. 1977

Enzyme

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Certain selected enzymes of carbohydrate metabolism were measured in samples of endometrium and myometrium from women who were premenopausal or postmenopausal. In addition, a number of samples of leiomyoma were obtained and assayed. Activities of several enzymes were higher in endometrium from premenopausal women compared to those in postmenopausal women; activities in myometrium were similar regardless of menopausal status. The activities of G6PD, ICD and GPI appeared to be lower in leiomyoma samples versus myométrial samples from premenopausal women; however, these differences were not apparent when enzyme activity was expressed per milligram protein.

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Glycolysis in the mouse uterus during the early post‐implantation stages of pregnancy and the effects of acute doses of ethanol

Murdoch

1987

Teratology

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The objective of this study was to assess the possibility that, in mice, alcohol interferes with uterine glycolysis to influence indirectly embryonal development. Glycolysis was found to be a major metabolic process in the mouse uterus and its pattern of activity changed during post-implantation pregnancy between days 5 and 9. This was evidenced by changes in glycolytic enzymes and intermediates, and in the capacity of endometrial preparations to consume oxygen and produce lactate during incubation in vitro. The intraperitoneal administration of ethanol at 3.0 and 6.0 gm/kg body weight, but not at 1.5 gm/kg body weight, on day 9 of pregnancy modified glycolysis in the uterus after 2 hours, resulting in significant changes in the rates of accumulation of glucose, glucose-6-phosphate, fructose-6-phosphate, fructose-1,6-diphosphate, and citrate. These effects were not mediated by changes in redox state, since the ratio of lactate to pyruvate remained unchanged after injection of ethanol. Citrate was considered to be a major factor involved both in the regulation of uterine glycolysis and in the ethanol-induced alterations in the levels of hexose phosphates. The elevated levels of uterine glucose registered after treatment with ethanol were related to an acceleration of glycogen degradation in the liver and not in the uterine endometrium. The results suggest that part of the adverse action that these doses of ethanol exert on embryonal development stems from indirect effects that involve uterine functions relating to the nurture of the conceptus via glycolysis.

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Metabolism of the Uterus of the Rat During Early Pseudopregnancy and Its Regulation by Estrogen and Progestogen

Cited by 17 publications

References 0 publications

Glucose Utilization by the Myometrium During Early Pseudopregnancy in the Rat

Glucose Utilization by the Myometrium During Early Pseudopregnancy in the Rat

Enzyme Activities in Human Endometrium, Myometrium and Leiomyomas of the Uterus

Glycolysis in the mouse uterus during the early post‐implantation stages of pregnancy and the effects of acute doses of ethanol

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