Metabolism of vitamin D2 and vitamin D3 in the rachitic chick

Imrie, M.H.; Neville, P.F.; Snellgrove, A.W.; DeLuca, Hector F.

doi:10.1016/0003-9861(67)90513-9

Cited by 75 publications

(25 citation statements)

References 20 publications

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“…If liver catabolizes ergocalciferol faster than cholecalciferol, then our results could be explained by more rapid clearance of ergocalciferol from the circulation. This phenomenon was not apparent in the previous work of Drescher et al (1969), Imrie et al (1967) or Jones et al (1975). All of these previous experiments suggested that the point of discrimination against ergocalciferol by the chick was at the 25(OH)D level.…”

Section: Concentrationsmentioning

confidence: 67%

Discrimination in the metabolism of orally dosed ergocalciferol and cholecalciferol by the pig, rat and chick

Horst¹,

Napoli²,

Littledike³

1982

Biochemical Journal

108

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Vitamin D-deficient pigs, rats and chicks were repleted with four daily oral doses of crystalline ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) containing equal concentrations of each. At 24 h after the last dose, the plasma of each species was analysed for vitamin D and 25-hydroxyvitamin D by standard methods. The mean (+/- S.D.) ratios of plasma cholecalciferol to ergocalciferol concentration were 1.5 +/- 0.1 (pig). 1.7 +/- 0.1 (rat) and 6.3 +/- 1.2 (chick). The mean ratios of plasma 25-hydroxycholecalciferol to 25-hydroxyergocalciferol concentration were 4.0 +/- 0.1 (pig), 0.4 +/- 0.02 (rat) and 10.7 +/- 3.4 (chick). The mean plasma cholecalciferol/ergocalciferol ratios for the 24,25-dihydroxy-, 25,26-dihydroxy- and 1,25-dihydroxy-derivatives in the pig were 2.6 +/- 0.6, 5.8 +/- 1.3 and 5.8 +/- 0.8 respectively. This is the first evidence that mammals other than the New World monkey, like birds, discriminate between ergocalciferol and cholecalciferol. These data, therefore, suggest that species discrimination between the different forms of vitamin D is probably a general phenomenon in mammals. Moreover, this is the first indication of a species (rat) that discriminates against a cholecalciferol metabolite in favour of an ergocalciferol metabolite. Species discrimination against particular forms of vitamin D may be important to the choice of experimental animal models for studying the regulation of vitamin D metabolism and may also be an important consideration in dietary vitamin supplementation.

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Section: Concentrationsmentioning

confidence: 67%

Discrimination in the metabolism of orally dosed ergocalciferol and cholecalciferol by the pig, rat and chick

Horst¹,

Napoli²,

Littledike³

1982

Biochemical Journal

108

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“…One of the other interesting studies in this regard is the recent study 'by Imrie et al (3) of the time course of appearance and disappearance of radiolabeled vitamins D2 and D3 in various organs of the chicken. One of the other interesting studies in this regard is the recent study 'by Imrie et al (3) of the time course of appearance and disappearance of radiolabeled vitamins D2 and D3 in various organs of the chicken.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Binding Globulin in the Rat: Specificity for the Vitamins D

Rikkers

Kletziens

DeLuca

1969

Experimental Biology and Medicine

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1tion steps prior to being placed on a linear sucrose gradient. The mean density of the sporozoites isolated from the peak fraction was 1.157 g/cm3 and the number of sporozoites recovered per mosquito was estimated to be 45,000. The technique can readily be extended to the isolation of sporozoites of other plasmodia1 species and produces a greater yield than is possible by conventional dissection methods .

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“…The diet consisted of the following percentages: sucrose, 42.6; corn starch, 10.3; soy protein, 26.3: DL-methionine, 0.6; glycine, 0.4: gelatin, 3.1; cottonseed oil, 6.2; CaHPO4 2H20, 2.5" KCI, 0.9: CaCO3, 5.9; NaCI, 0.4; trace salts, 0.7, and vitamin mixture, 0.2. The components of trace salts and vitamin mixture were the same as those described by Imrie et al [12]. After they were maintained on this diet for 2 weeks, 70 birds, whose egg production rate was more than 70%, were selected and divided into two groups (A: 20 birds and B: 50 birds).…”

Section: Animals and Dietsmentioning

confidence: 99%

The role of vitamin D in the medullary bone formation in egg-laying japanese quail and in immature male chicks treated with sex hormones

et al. 1983

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The effect of vitamin D3 on medullary bone formation was investigated in egg-laying Japanese quail and in immature male chicks treated with sex hormones. When laying quail were fed a vitamin D-deficient diet for 16 days, their eggshell weights and egg production rate were markedly reduced in a time-dependent manner with a significant decrease in plasma calcium and 25-hydroxyvitamin D3 levels. The calcium content of the medullary bone of femurs decreased markedly with the progress of vitamin D deficiency, whereas that of the cortical bone remained unchanged. Quantitative histological examination also showed that the area of the mineralized portion of medullary bone in quail that were fed the vitamin D-deficient diet markedly decreased compared with that in the control laying quail, whereas the total area of the mineralized and unmineralized portions of medullary bone in the bone marrow cavity increased moderately. Daily administration of vitamin D3 (0.75 microgram/day) to the vitamin D-deficient quail increased the mineralization of medullary bone as early as day 4. Daily administration of both estradiol (0.3 mg/day) and testosterone (0.9 mg/day) for 3 weeks to immature male chicks induced an apparent hypercalcemia and matrix formation of medullary bone, regardless of the vitamin D status of the chicks. Mineralization of medullary bone was observed only when vitamin D3 was administered together with the sex hormones. These results suggest that vitamin D3 is directly involved in the mineralization of medullary bone in birds.

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Metabolism of vitamin D2 and vitamin D3 in the rachitic chick

Cited by 75 publications

References 20 publications

Discrimination in the metabolism of orally dosed ergocalciferol and cholecalciferol by the pig, rat and chick

Discrimination in the metabolism of orally dosed ergocalciferol and cholecalciferol by the pig, rat and chick

Vitamin D Binding Globulin in the Rat: Specificity for the Vitamins D

The role of vitamin D in the medullary bone formation in egg-laying japanese quail and in immature male chicks treated with sex hormones

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