Metabolism

Brookes, Paul S.; Taegtmeyer, Heinrich

doi:10.1161/circulationaha.117.031372

Cited by 11 publications

(3 citation statements)

References 14 publications

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“…Low PFK1 activity caused by expression of a cardiac-specific, kinase-deficient PFK2 transgene (Glyco Lo mice) seems sufficient to partially phenocopy the exercise-adapted heart and to regulate genes (eg, Cebpb , Cited4 116 , 117 ) required for exercise-induced cardiac growth. 80 , 118 Activation of the exercise gene program in Glyco Lo mice occurs in the absence of Akt activation, 80 which normally regulates physiological cardiac growth. 34 , 45 , 119 This suggests that periodic, exercise-mediated decreases in glycolysis may be a proximal propagator of the growth program.…”

Section: Role Of Metabolism In Exercise-induced Cardiac Growthmentioning

confidence: 99%

Metabolic Coordination of Physiological and Pathological Cardiac Remodeling

Gibb

Hill

2018

Circulation Research

272

232

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Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell phenotype. In particular, the heart consumes relatively large amounts of substrate not only to regenerate ATP for contraction but also to sustain biosynthetic reactions for replacement of cellular building blocks. Metabolic pathways also control intracellular redox state, and metabolic intermediates and end products provide signals that prompt changes in enzymatic activity and gene expression. Mounting evidence suggests that the changes in cardiac metabolism that occur during development, exercise, and pregnancy as well as with pathological stress (eg, myocardial infarction, pressure overload) are causative in cardiac remodeling. Metabolism-mediated changes in gene expression, metabolite signaling, and the channeling of glucose-derived carbon toward anabolic pathways seem critical for physiological growth of the heart, and metabolic inefficiency and loss of coordinated anabolic activity are emerging as proximal causes of pathological remodeling. This review integrates knowledge of different forms of cardiac remodeling to develop general models of how relationships between catabolic and anabolic glucose metabolism may fortify cardiac health or promote (mal)adaptive myocardial remodeling. Adoption of conceptual frameworks based in relational biology may enable further understanding of how metabolism regulates cardiac structure and function.

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Section: Role Of Metabolism In Exercise-induced Cardiac Growthmentioning

confidence: 99%

Metabolic Coordination of Physiological and Pathological Cardiac Remodeling

Gibb

Hill

2018

Circulation Research

272

232

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“…Moreover, studies in both humans and animal models suggest that exercise can lower oxygen extraction ratios for glucose and decrease glucose uptake and utilization ( 198 , 213 ). Recent findings suggest that relatively prolonged, intense endurance exercise can decrease glucose catabolism in the heart by diminishing the activity of phosphofructokinase ( 214 , 215 ). Collectively, these findings suggest that exercise can acutely increase or decrease both circulating glucose levels and myocardial use in a manner dependent on the type, intensity, or duration of exercise.…”

Section: How Does Cardiac Metabolism Change During Exercise?mentioning

confidence: 99%

Metabolic Mechanisms of Exercise-Induced Cardiac Remodeling

Fulghum

Hill²

2018

Front. Cardiovasc. Med.

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Exercise has a myriad of physiological benefits that derive in part from its ability to improve cardiometabolic health. The periodic metabolic stress imposed by regular exercise appears fundamental in driving cardiovascular tissue adaptation. However, different types, intensities, or durations of exercise elicit different levels of metabolic stress and may promote distinct types of tissue remodeling. In this review, we discuss how exercise affects cardiac structure and function and how exercise-induced changes in metabolism regulate cardiac adaptation. Current evidence suggests that exercise typically elicits an adaptive, beneficial form of cardiac remodeling that involves cardiomyocyte growth and proliferation; however, chronic levels of extreme exercise may increase the risk for pathological cardiac remodeling or sudden cardiac death. An emerging theme underpinning acute as well as chronic cardiac adaptations to exercise is metabolic periodicity, which appears important for regulating mitochondrial quality and function, for stimulating metabolism-mediated exercise gene programs and hypertrophic kinase activity, and for coordinating biosynthetic pathway activity. In addition, circulating metabolites liberated during exercise trigger physiological cardiac growth. Further understanding of how exercise-mediated changes in metabolism orchestrate cell signaling and gene expression could facilitate therapeutic strategies to maximize the benefits of exercise and improve cardiac health.

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“…More recently, rat cardiomyocyte and in vivo studies demonstrated that glucose consumption and subsequent higher levels of intracellular aspartate as a nitrogen donor for nucleotide synthesis were necessary to promote cardiac hypertrophy ( 102 ). Other proteins and small-molecule metabolites have been proposed as metabolic signaling molecules in the hypertrophic response, although the mechanistic links and specific relevance to exercise training remain unclear ( 103 ).…”

Section: Exercise Substrate Metabolism and The Heartmentioning

confidence: 99%

Exercise, exerkines, and cardiometabolic health: from individual players to a team sport

Robbins¹,

Gerszten²

2023

Journal of Clinical Investigation

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Exercise confers numerous salutary effects that extend beyond individual organ systems to provide systemic health benefits. Here, we discuss the role of exercise in cardiovascular health. We summarize major findings from human exercise studies in cardiometabolic disease. We next describe our current understanding of cardiac-specific substrate metabolism that occurs with acute exercise and in response to exercise training. We subsequently focus on exercise-stimulated circulating biochemicals (“exerkines”) as a paradigm for understanding the global health circuitry of exercise, and discuss important concepts in this emerging field before highlighting exerkines relevant in cardiovascular health and disease. Finally, this Review identifies gaps that remain in the field of exercise science and opportunities that exist to translate biologic insights into human health improvement.

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Metabolism

Cited by 11 publications

References 14 publications

Metabolic Coordination of Physiological and Pathological Cardiac Remodeling

Metabolic Coordination of Physiological and Pathological Cardiac Remodeling

Metabolic Mechanisms of Exercise-Induced Cardiac Remodeling

Exercise, exerkines, and cardiometabolic health: from individual players to a team sport

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