Metabolite Antagonists.

Roblin, Richard O.

doi:10.1021/cr60120a003

Cited by 62 publications

(19 citation statements)

References 206 publications

(311 reference statements)

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“…Both together, in the proper concentrations, yielded excellent growth of the organism. Roblin (10) reported that Gladstone in 1939 observed a n amino acid antagonism between valine, leucine, and isoleucine. Gladstone, while studying the effect of amino acid conlbinations on the growth of Bacillt~s anthracis, noted that the omissioil of valille or of isoleucine from t h e medium had a depressant effect on the growth of the organism.…”

Section: O P T I C a L D E N S I T Ymentioning

confidence: 99%

The Nutrition of Vibrio Costicolus: I. A Simplified Synthetic Medium

Flannery¹,

Kennedy²

1962

Can. J. Microbiol.

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A liquid synthetic medium is described in which Vibrio costicolus grows well in 24 hours. The medium contains glucose, L-cystine, L-glutamic acid, L-arginine, DL-valine, DL-isoleucine, potassi~~m phosphate buffer, magnesium sulphate, sodium nitrate, and sodium chloride. The addition of 10 vitamins, 3 bases, 14 amino acids, and 5 salts did not improve the medium. No growth was obtained if cystine, glucose, or sodium chloride was omitted from the medium. The remaining constituents of the simplified medium were not essential but were found necessary for maximum growth. An amino acid antagonism was observed between valine and isoleucine. When added alone, either amino acid depressed the growth response, but when added together they were stimulatory.

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Section: O P T I C a L D E N S I T Ymentioning

confidence: 99%

The Nutrition of Vibrio Costicolus: I. A Simplified Synthetic Medium

Flannery¹,

Kennedy²

1962

Can. J. Microbiol.

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“…Nicotinic acid antagonists.-The antinicotinic acid activity of pyridine-3-sulfonic acid or its amide, of 3-acetylpyridine, and of S-thiazole carboxamide has already been mentioned in previous reviews (4,6).…”

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“…P-A minobenzoic acid (P AB) antagonists .-Considerable advance has been made in defining the mechanism of growth inhibition brought about by the sulfonamides since the subject was last reviewed (6,21,22). Recent experiments have continued to indi cate that one of the major effects of the sulfonamides on micro organisms involves the blocking of the incorporation of PAB into pteroylglutamic acid (23 to 28).…”

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“…Biotin antagonists.-A considerable number of biotin analogues have proved to be competitive antagonists of biotin (4,6). One of the most studied of these has been desthiobiotin.…”

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“…Pantothenic acid antagonists.-A large number of pantothenic acid antagonists have been discussed in previous reviews (4,6). A potent antipantothenic acid activity for a large number of lactic acid bacteria was shown by Drell & Dunn (116) to be exerted by w-methyl pantothenic acid (having a methyl group substituted for a hydrogen on the terminal hydroxyl group).…”

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Metabolic Inhibitors

Winzler¹

1949

Annu. Rev. Biochem.

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This review has been limited to a consideration of those meta bolic inhibitors which exert their effects by virtue of their struc tural similarity to compounds playing a role in metabolism and growth. Previous reviews by Woolley, by Welch, and by Roblin (1 to 6) have shown the concept of competitive antagonism toward essential metabolites by compounds of similar structure to be so well established as to require little further justification.General considerations.-The high hopes held forth for the development of new chemotherapeutic agents based on a rational application of this principle [e.g. (7)] have not yet been realized. However, such metabolic antagonists have already begun to be of service in elucidating metabolic functions of certain metabolites, as well as the pathways· of certain biosyntheses.A technique termed "inhibition analysis" has been applied in a series of papers by Shive and his co-workers to the study of the effect of a number of antagonists on bacterial growth (8 to 16). The procedure is based on the assumption that, if a metabolic inhibitor blocks a particular reaction and thus limits bacterial growth, addition of the product of the blocked reaction should permit growth. At higher concentrations of the antagonist, a second reaction may be inhibited, whereupon the addition of the product of the second reaction then still further reduces the sen sitivitity of the organism to the inhibitor.· A number of agents other than the competing metabolite itself may reverse the inhibiting effect of a metabolic antagonist, each giving characteristic changes in the inhibition index and showing characteristic competitive or noncompetitive behavior (16).That too facile interpretation of the results of inhibition analysis is possible was pointed out by Hitchings et al. (17), when. it was observed that an entirely abnormal compound, S-bromouracil, was implicated as a metabolic product of a reaction in the growth of Escherichia coli inhibited by S-nitrouracil. Other difficulties m 1 Annu. Rev. Biochem. 1949.18:535-558. Downloaded from www.annualreviews.org Access provided by University of California -Davis on 02/03/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS Annu. Rev. Biochem. 1949.18:535-558. Downloaded from www.annualreviews.org Access provided by University of California -Davis on 02/03/15. For personal use only. Annu. Rev. Biochem. 1949.18:535-558. Downloaded from www.annualreviews.org Access provided by University of California -Davis on 02/03/15. For personal use only.

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Interrelations in Microorganisms: Between Growth and the Metabolism of Vitamin‐like Substances

McIlwain¹

1947

Advances in Enzymology - And Related Areas of Molecular Biology

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Metabolite Antagonists.

Cited by 62 publications

References 206 publications

The Nutrition of Vibrio Costicolus: I. A Simplified Synthetic Medium

The Nutrition of Vibrio Costicolus: I. A Simplified Synthetic Medium

Metabolic Inhibitors

Interrelations in Microorganisms: Between Growth and the Metabolism of Vitamin‐like Substances

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