Metabolite Differences in the Lenticular Nucleus in Type 2 Diabetes Mellitus Shown by Proton MR Spectroscopy

Lin, Yanzhu; Lin, Sha; Li, Y.; Qu, Xiaohan; Liu, L.; Chen, H.; An, Zhen-ni; Wang, Y.; Sun, Caifeng

doi:10.3174/ajnr.a3492

Cited by 16 publications

(19 citation statements)

References 19 publications

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“…Previous studies have shown that decreased NAA is associated with impaired neuronal viability, and correlated significantly with the severity of white‐matter disease . In patients with Type 2 diabetes mellitus (T2DM), the NAA levels have also been repeatedly shown to be altered . In addition, it has been confirmed that regional reductions of cerebral blood flow, as well as ischemia and hypoxia, can be found in both diabetic rodents and patients .…”

Section: Discussionmentioning

confidence: 87%

“…36 In patients with Type 2 diabetes mellitus (T2DM), the NAA levels have also been repeatedly shown to be altered. [37][38][39] In addition, it has been confirmed that regional reductions of cerebral blood flow, as well as ischemia and hypoxia, can be found in both diabetic rodents and patients. 40 These changes could impede the delivery of nutrients and oxygen to the brain, thus affecting cerebral energy metabolism and neuronal function.…”

Section: Metabolic Alterations In the Visual Cortexmentioning

confidence: 84%

“…17 The studies investigating the effects of diabetes on Cho metabolism have indicated diverging results. 22,37,38,[52][53][54] Some articles reported an increase of Cho, whereas others reported decreased Cho/Cr ratios or no significant change. In our study, we found a significant decrease in the Cho/Cr ratio in the visual cortex in DM rats compared with controls.…”

Section: Metabolic Alterations In the Visual Cortexmentioning

confidence: 99%

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Metabolic profile of visual cortex in diabetic rats measured with in vivo proton MRS

Wang

Yang

et al. 2017

NMR in Biomedicine

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The purpose of the present study was to characterize the metabolic profile of the visual cortex in streptozotocin-induced Type 1 diabetic rats by means of in vivo proton MRS. Several metabolite concentration ratios in the visual cortex were calculated. In addition, postmortem histologic analyses for retinal ganglion cell (RGC) loss, optic nerve injury and visual cortex alterations were monitored. The results showed that diabetes induced several changes in visual cortex metabolites, such as reduced N-acetylaspartate, glutamate, γ-aminobutyric acid, taurine and choline-containing compound levels. Nevertheless, myo-inositol levels increased significantly as compared with controls. Remarkable RGC loss and optic nerve degeneration were observed by morphological analysis. Moreover, the results showed significant neuronal loss and glial activation in the visual cortex. These findings indicated that, besides vascular abnormalities, neuronal loss and degeneration in the visual pathway were induced due to disrupted glucose homeostasis in diabetes. Metabolic or functional abnormalities were induced in cerebral neurons of the visual cortex by diabetes.

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Section: Discussionmentioning

confidence: 87%

Section: Metabolic Alterations In the Visual Cortexmentioning

confidence: 84%

Section: Metabolic Alterations In the Visual Cortexmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic profile of visual cortex in diabetic rats measured with in vivo proton MRS

Wang

Yang

et al. 2017

NMR in Biomedicine

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“…Both human and animal MRS studies of DM suggest a decrease in the N-acetylaspartate (NAA)/creatine (Cr) ratio in a relatively consistent manner, while there are mixed results for the choline (Cho)/Cr ratio [77]. In a study using a rat model of DM, reductions in the NAA/Cr ratio and the NAA/Cho ratio were observed in diabetic rats, whereas the Cr/Cho rate was not significantly changed [78].…”

Section: Neural Correlates Of Neurocognitive Impairment In T2dm: Evidmentioning

confidence: 99%

“…A study reported that the Cho/Cr ratio was decreased in the frontal and parietal lobes of patients with T2DM [81], while another study observed an increase in the occipital lobe [82]. In the most recent MRS study on T2DM, a decrease in the NAA/Cr ratio and an increase in the Cho/Cr ratio in the lenticular nucleus were noted [77]. The literature suggests an association between NAA and neuronal damage, as well as one between Cho and glial proliferation [83].…”

Section: Neural Correlates Of Neurocognitive Impairment In T2dm: Evidmentioning

confidence: 99%

Neurocognitive Changes and Their Neural Correlates in Patients with Type 2 Diabetes Mellitus

et al. 2014

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As the prevalence and life expectancy of type 2 diabetes mellitus (T2DM) continue to increase, the importance of effective detection and intervention for the complications of T2DM, especially neurocognitive complications including cognitive dysfunction and dementia, is receiving greater attention. T2DM is thought to influence cognitive function through an as yet unclear mechanism that involves multiple factors such as hyperglycemia, hypoglycemia, and vascular disease. Recent developments in neuroimaging methods have led to the identification of potential neural correlates of T2DM-related neurocognitive changes, which extend from structural to functional and metabolite alterations in the brain. The evidence indicates various changes in the T2DM brain, including global and regional atrophy, white matter hyperintensity, altered functional connectivity, and changes in neurometabolite levels. Continued neuroimaging research is expected to further elucidate the underpinnings of cognitive decline in T2DM and allow better diagnosis and treatment of the condition.

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Change in medial frontal cerebral metabolite concentrations following bariatric surgery

et al. 2023

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Obesity is associated with adverse effects on brain health, including an increased risk of neurodegenerative diseases. Changes in cerebral metabolism may underlie or precede structural and functional brain changes. While bariatric surgery is known to be effective in inducing weight loss and improving obesity-related medical comorbidities, few studies have examined whether it may be able to improve brain metabolism. In the present study, we examined changes in cerebral metabolite concentrations in participants with obesity who underwent bariatric surgery. Thirty-five patients with obesity (body mass index ≥ 35 kg/m 2 ) were recruited from a bariatric surgery candidate nutrition class. They completed single voxel proton magnetic resonance spectroscopy at baseline (presurgery) and within 1 year postsurgery. Spectra were obtained from a large medial frontal brain region using a PRESS sequence on a 3-T Siemens Verio scanner. The acquisition parameters were TR = 3000 ms and TE = 37 ms. Tissue-corrected metabolite concentrations were determined using Osprey. Paired t-tests were used to examine within-subject change in metabolite concentrations, and correlations were used to relate these changes to other healthrelated outcomes, including weight loss and glycated hemoglobin (HbA 1c ), a measure of blood sugar levels. Bariatric surgery was associated with a reduction in cerebral choline-containing compounds (Cho; t [34] = À 3.79, p < 0.001, d = À0.64) and myo-inositol (mI; t [34] = À 2.81, p < 0.01, d = À0.47) concentrations. There were no significant changes in N-acetyl-aspartate, creatine, or glutamate and glutamine concentrations. Reductions in Cho were associated with greater weight loss (r = 0.40, p < 0.05), and reductions in mI were associated with greater reductions in HbA 1c (r = 0.44, p < 0.05). In conclusion, participants who underwent bariatric surgery exhibited reductions in cerebral Cho and mI concentrations, which were associated with improvements in weight loss and glycemic control. Given that elevated levels of Cho and mI have been implicated in neuroinflammation, reduction in these metabolites after bariatric surgery may reflect amelioration of obesity-related neuroinflammatory processes. As such, our results provide evidence that bariatric surgery may improve brain health and metabolism in individuals with obesity.

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Metabolite Differences in the Lenticular Nucleus in Type 2 Diabetes Mellitus Shown by Proton MR Spectroscopy

Cited by 16 publications

References 19 publications

Metabolic profile of visual cortex in diabetic rats measured with in vivo proton MRS

Metabolic profile of visual cortex in diabetic rats measured with in vivo proton MRS

Neurocognitive Changes and Their Neural Correlates in Patients with Type 2 Diabetes Mellitus

Change in medial frontal cerebral metabolite concentrations following bariatric surgery

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