Metabolite of tryptophan promoting changes in EEG signal and the oxidative status of the brain

Abstract

Tryptophan is an essential amino acid precursor of neurotransmitter serotonin and triptamine. During its metabolism, indole-3-acetic acid (IAA) is generated; this substance presents both antioxidant and prooxidant effects in different biological systems in addition to hipoglicemic effects. To date, electroencephalography (EEG) has been used to evaluate the temporal effect of several substances in neurotransmission. The goal of this study was to characterize the effect of IAA in the brain by analysing the EEG signal and evaluate the oxidative status by means of biochemical parameters. The EEG was acquired by using a noninvasive method, and the brain electric signal was analysed by advanced digital signal processing techniques to determinate the energy signal filtered in different band frequencies. Furthermore, the oxidative status of the brain was investigated by measuring the activity of antioxidant enzymes and lipid peroxidation as well as blood glucose rates of the animals treated with different doses of IAA. Our results showed the relationship of IAA administration with changes in EEG signals. The oxidative status of the brain was modified by IAA after 14 days of treatment.

Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial

“…In rats, metabolomics analysis of urine also identified a change in tryptophan metabolism in the vinegar treated animals in comparison to controls [12]. These data are intriguing given the antioxidant role of indole-3-acetic acid in biological systems, including brain, and the well-documented role of tryptophan in production of the stress-alleviating neurotransmitter serotonin [13][14][15]. These data suggest a potential, unexplored role for vinegar in mental health.…”

Metabolômica >i<untargeted>/i< em urina de portadores de >i<Cri Du Chat>/i< utilizando cromatografia a gás e espectrometria de massas (GC-MS)

“…(BENDER, 1982). Durante a via biossintética, o ácido indolacético é gerado como produto da degradação do triptofano sob a ação das bactérias presentes no intestino, ou através de processos endógenos pela desaminação oxidativa da triptamina mediada pela enzima monoamina oxidase (FERRARI et al, 2014).…”