Metabolite Profile and Bioactivity ofMusa X ParadisiacaL. Flower Extracts

Abstract

The flower extracts of two cultivated varieties of Musa X paradisiaca viz. Kanthali and Kancha Kela were assayed against the enzymes α‐amylase, α‐glucosidase, acetylcholinesterase, β‐glucuronidase and Angiotensin I Converting Enzyme, which are related to different diseased states like diabetes, Alzheimer's disease, hepatic disorder and cardiovascular diseases, respectively. The extracts inhibited all the enzymes except α‐amylase by Musa X paradisiaca cv. Kanthali. Significantly high activities were observed in both the cultivated varieties for inhibiting the enzymes β‐glucuronidase and Angiotensin I Converting Enzyme with respect to the known inhibitors of such enzymes silymarin and Lisinopril, respectively. The chemical constituents present in the methanol extracts were profiled following GC‐MS based metabolomics approach. Eleven organic acids, seven sugars and sugar alcohols, six fatty acids, three phenols, two amino acids and a sterol could be identified. Practical Applications The male flowers of Musa X paradisiaca are cooked as vegetable in South‐East Asia. The flowers are also useful in diabetes. Enzyme inhibitors have properties to prevent or control different noninfectious diseases. So, the flower extracts of two varieties of the plant were assayed for their activities against the glycosidases, acetylcholinesterase, β‐glucuronidase and Angiotensin I Converting Enzyme. The activities of the flower extracts against the enzymes suggest that they may have beneficial effects in controlling diseases.

Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants

“…Therefore, research has turned towards biological sources like plant extracts. It has been reported that the methanolic extracts of Musa X paradisiaca inhibited ACE by 68.63%–98.3% [ 12 ]. In another study, the ACE-inhibitory activity of citrus leaf extracts were reported in rats fed with palm oil heated five times [ 13 ].…”

The Determination of Inhibition Effect of Extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on Angiotensin Converting Enzyme

“…The drugs was used in hypertensive teratment has side effects so, investigations was turned into biological sources such as herb extracts. It has been demonstrated that the methanolic extracts of Musa X paradisiaca inhibited ACE activity by 68.63%-98.3% (Acharya et al, 2016). In other work, the ACEinhibitory effect of citrus leaf extracts were showed in rats fed with palm oil heated five times (Siti et al, 2017) .…”

Effect of consuming lactogenic biscuits formulated with banana (Musa x paradisiaca) flower flour on expressed breast milk (EBM) among lactating working women

“…Banana flower of Musa x paradisiaca sp. also showed a significant high capability to inhibit enzymes β-glucuronidase and Angiotensin I Converting enzyme that could control non-infectious diseases (Acharya et al, 2016). The presence of antioxidant properties in Musa x paradisiaca flower extract could prevent free radical and control cells damage (Mahmood et al, 2011), which capable to contribute towards healthy lactation.…”