Metabolite profiling and genomic properties of an endophytic Bacillus siamensis strain with anti-tumor activity isolated from medicinal plant Curcuma Wenyujin

Huang, Xiaoping; Chen, Zhehao; Wang, Lilin; Ran, Juan; Wang, Juling; Jiang, Jie; Zhang, Daoxiang; Xiang, Taihe; Zeng, Zhanghui

doi:10.1007/s11240-023-02671-8

Plant Cell Tiss Organ Cult

2024

DOI: 10.1007/s11240-023-02671-8

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Metabolite profiling and genomic properties of an endophytic Bacillus siamensis strain with anti-tumor activity isolated from medicinal plant Curcuma Wenyujin

Xiaoping Huang,

Zhehao Chen,

Lilin Wang

et al.

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The role and mechanism of “eight famous herbals in Zhejiang” in cancer via network pharmacology and experimental validation

Ni,

Zhang,

Chen

et al. 2024

Front. Oncol.

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In recent years, some components and active ingredients from the herbal formula “eight famous herbals in Zhejiang” (Zhe-Ba-Wei) have been reported to possess antitumor properties. However, there is still no systemic study on the role and mechanism of Zhe-Ba-Wei in cancer. To systematically investigate the anticancer efficacy of Zhe-Ba-Wei, we first identified 16 reported active ingredients with gene targets associated with various types of tumors. Second, we screened these active ingredients and their responding multiple shared targets by analyzing the convergence of diverse and tumor-specific target sites and identified four crucial active ingredients (ferulic acid, quercetin, rutin, luteolin), which were characterized by 27 overlapping gene targets. Third, these 27 gene targets were subsequently mapped onto the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology term, and among the 27 total potential targets, 12 were involved in plasma membrane function. Fourth, we investigated the binding affinities between the four crucial active ingredients and their potential targets such as EGFR and MET, both of which are well-known oncogenes in various cancers. Subsequently, an investigation of the computational ADMET properties showed that most of these four ingredients exhibited good ADMET properties. Finally, we found that three active ingredients (ferulic acid, luteolin, and quercetin) could inhibit the proliferation of NSCLC cells and decrease the protein expression of EGFR in a concentration-dependent manner. All these results shed light on the bioactive components, pharmacological effects, and drug development and utilization of Zhe-Ba-Wei, aiming to provide useful support for its further research and clinical application.

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The role and mechanism of “eight famous herbals in Zhejiang” in cancer via network pharmacology and experimental validation

Ni,

Zhang,

Chen

et al. 2024

Front. Oncol.

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Metabolite profiling and genomic properties of an endophytic Bacillus siamensis strain with anti-tumor activity isolated from medicinal plant Curcuma Wenyujin

Cited by 1 publication

References 82 publications

The role and mechanism of “eight famous herbals in Zhejiang” in cancer via network pharmacology and experimental validation

The role and mechanism of “eight famous herbals in Zhejiang” in cancer via network pharmacology and experimental validation

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